From lymphatic endothelial cell migration to formation of tubular lymphatic vascular network [PDF]
Frontiers in Physiology, 2023 During development, lymphatic endothelial cell (LEC) progenitors differentiate from venous endothelial cells only in limited regions of the body. Thus, LEC migration and subsequent tube formation are essential processes for the development of tubular ...
Tomohiro Shiiya, Masanori Hirashima
doaj +4 more sources
Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice. [PDF]
PLoS ONE, 2012 The coxsackie- and adenovirus receptor (CAR) is a cell adhesion molecule predominantly associated with epithelial tight junctions in adult tissues. CAR is also expressed in cardiomyocytes and essential for heart development up to embryonic day 11.5, but ...
Momina Mirza +8 more
doaj +3 more sources
Digging deeper into lymphatic vessel formation
BMC Cell Biology, 2011 Background Abnormal lymphatic vessel formation (lymphangiogenesis) is associated with different pathologies such as cancer, lymphedema, psoriasis and graft rejection.
Thiry Marc +9 more
doaj +3 more sources
The Lymphatic Endothelial Cell Secretome Inhibits Osteoblast Differentiation and Bone Formation [PDF]
Cells, 2023 Complex lymphatic anomalies (CLAs) are a set of rare diseases with unique osteopathic profiles. Recent efforts have identified how lymphatic-specific somatic activating mutations can induce abnormal lymphatic formations that are capable of invading bone ...
Ernesto Solorzano +8 more
doaj +2 more sources
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program [PDF]
Nature Communications, 2018 Mechanical cues are known to influence endothelial cell behavior. Here Frye et al. show that lymphatic endothelial cell progenitors experience varying degrees of matrix stiffness during development, and that matrix stiffness regulates GATA2 expression to
Maike Frye +13 more
doaj +5 more sources
Lymphangiogenesis in breast carcinoma is present but insufficient for metastatic spread [PDF]
Journal of Health Sciences, 2014 Introduction: The lymphatic vasculature is an important route for the metastatic spread of human cancer. However, the extent to which this depends on lymphangiogenesis or on invasion of existing lymph vessels remains controversial. The goal of this study
Mirsad Dorić +5 more
doaj +4 more sources
FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake [PDF]
Molecular Medicine, 2020 Background Therapeutic lymphangiogenesis in an orthotopic lung transplant model has been shown to improve acute allograft rejection that is mediated at least in part through hyaluronan drainage.
Shikshya Shrestha +10 more
doaj +2 more sources
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity [PDF]
eLife, 2020 Endothelial integrity is vital for homeostasis and adjusted to tissue demands. Although fluid uptake by lymphatic capillaries is a critical attribute of the lymphatic vasculature, the barrier function of collecting lymphatic vessels is also important by ...
Maike Frye +10 more
doaj +2 more sources
Cells, 2023 At present, only a few reports have addressed the possible contribution of the lymphatic vascular system to the pathogenesis of systemic sclerosis (SSc).
Irene Rosa +6 more
doaj +1 more source
Plasticity of blood- and lymphatic endothelial cells and marker identification. [PDF]
PLoS ONE, 2013 The distinction between lymphatic and blood vessels is biologically fundamental. Here we wanted to rigorously analyze the universal applicability of vascular markers and characteristics of the two widely used vascular model systems human microvascular ...
Johannes Keuschnigg +8 more
doaj +1 more source