Results 1 to 10 of about 5,519,715 (191)
The Lymphatic Endothelial Cell Secretome Inhibits Osteoblast Differentiation and Bone Formation [PDF]
Cells, 2023 Complex lymphatic anomalies (CLAs) are a set of rare diseases with unique osteopathic profiles. Recent efforts have identified how lymphatic-specific somatic activating mutations can induce abnormal lymphatic formations that are capable of invading bone ...
Ernesto Solorzano +8 more
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From lymphatic endothelial cell migration to formation of tubular lymphatic vascular network [PDF]
Frontiers in Physiology, 2023 During development, lymphatic endothelial cell (LEC) progenitors differentiate from venous endothelial cells only in limited regions of the body. Thus, LEC migration and subsequent tube formation are essential processes for the development of tubular ...
Tomohiro Shiiya, Masanori Hirashima
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Aberrant lymphatic endothelial progenitors in lymphatic malformation development. [PDF]
PLoS ONE, 2015 Lymphatic malformations (LMs) are vascular anomalies thought to arise from dysregulated lymphangiogenesis. These lesions impose a significant burden of disease on affected individuals.
June K Wu +10 more
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Plasticity of blood- and lymphatic endothelial cells and marker identification. [PDF]
PLoS ONE, 2013 The distinction between lymphatic and blood vessels is biologically fundamental. Here we wanted to rigorously analyze the universal applicability of vascular markers and characteristics of the two widely used vascular model systems human microvascular ...
Johannes Keuschnigg +8 more
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Lymphatic Endothelial-to-Myofibroblast Transition: A Potential New Mechanism Underlying Skin Fibrosis in Systemic Sclerosis [PDF]
Cells, 2023 At present, only a few reports have addressed the possible contribution of the lymphatic vascular system to the pathogenesis of systemic sclerosis (SSc).
Irene Rosa +6 more
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Cooperative ETS transcription factors are required for lymphatic endothelial cell integrity and resilience [PDF]
The Journal of Clinical InvestigationLymphatics maintain fluid homeostasis, immune surveillance, and tissue integrity. Here, we identified the E26 transformation-specific transcription factors Erg and Fli1 as essential cooperative regulators of lymphatic integrity and function.
Myung Jin Yang +11 more
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An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo. [PDF]
PLoS ONE, 2013 Afadin is an intracellular binding partner of nectins, cell-cell adhesion molecules, and plays important roles in the formation of cell-cell junctions. Afadin-knockout mice show early embryonic lethality, therefore little is known about the function of ...
Takashi Majima +8 more
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Scientific Reports, 2022 Claudin-3 is a tight junction protein that has often been associated with the progression and metastasis of various tumors. Here, the role of claudin-3 in tumor-induced lymphangiogenesis is investigated.
Ningjing Lei +9 more
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Frontiers in Cell and Developmental Biology, 2021 Microenvironmental signals produced during development or inflammation stimulate lymphatic endothelial cells to undergo lymphangiogenesis, in which they sprout, proliferate, and migrate to expand the vascular network.
Delayna Paulson +10 more
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Neoplasia: An International Journal for Oncology Research, 2006 Oral treatment with the dual-receptor tyrosine kinase inhibitor AEE788 effectively reduces the number of peritumoral lymphatic vessels and the incidence of lymph node metastasis in nude mice with human HT29 colon cancer cells growing in the cecum ...
Robert B. Rebhun +5 more
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