Results 21 to 30 of about 107,605 (342)
Molecular characterization of lymphatic endothelial cells [PDF]
Proceedings of the National Academy of Sciences, 2002 The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial fluid and proteins and is an important entry point for leukocytes and tumor cells. Specialized functions of lymphatics suggest differences in the molecular composition of the lymphatic and blood vascular endothelium.
Simona Podgrabinska +6 more
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An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo. [PDF]
PLoS ONE, 2013 Afadin is an intracellular binding partner of nectins, cell-cell adhesion molecules, and plays important roles in the formation of cell-cell junctions. Afadin-knockout mice show early embryonic lethality, therefore little is known about the function of ...
Takashi Majima +8 more
doaj +1 more source
Scientific Reports, 2022 Claudin-3 is a tight junction protein that has often been associated with the progression and metastasis of various tumors. Here, the role of claudin-3 in tumor-induced lymphangiogenesis is investigated.
Ningjing Lei +9 more
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Cell Fate Determination of Lymphatic Endothelial Cells [PDF]
International Journal of Molecular Sciences, 2020 The lymphatic vasculature, along with the blood vasculature, is a vascular system in our body that plays important functions in fluid homeostasis, dietary fat uptake, and immune responses. Defects in the lymphatic system are associated with various diseases such as lymphedema, atherosclerosis, fibrosis, obesity, and inflammation.
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Microenvironmental signals produced during development or inflammation stimulate lymphatic endothelial cells to undergo lymphangiogenesis, in which they sprout, proliferate, and migrate to expand the vascular network.
Delayna Paulson +10 more
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Ethanol-induced lymphatic endothelial cell permeability via MAP-kinase regulation.
Am J Physiol Cell Physiol, 2021 Herrera M, Molina P, Souza-Smith FM.
europepmc +2 more sources
Aberrant lymphatic endothelial progenitors in lymphatic malformation development.
PLoS ONE, 2015 Lymphatic malformations (LMs) are vascular anomalies thought to arise from dysregulated lymphangiogenesis. These lesions impose a significant burden of disease on affected individuals.
June K Wu +10 more
doaj +1 more source
T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions. [PDF]
, 2017 T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo ...
Coles, Marc +10 more
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Lymphatic Endothelial Cell Progenitors in the Tumor Microenvironment. [PDF]
Adv Exp Med Biol, 2020 Tumor lymphatics play a key role in cancer progression as they are solely responsible for transporting malignant cells to regional lymph nodes (LNs), a process that precedes and promotes systemic lethal spread. It is broadly accepted that tumor lymphatic sprouting is induced mainly by soluble factors derived from tumor-associated macrophages (TAMs) and
Ran S, Volk-Draper L.
europepmc +4 more sources
Neoplasia: An International Journal for Oncology Research, 2006 Oral treatment with the dual-receptor tyrosine kinase inhibitor AEE788 effectively reduces the number of peritumoral lymphatic vessels and the incidence of lymph node metastasis in nude mice with human HT29 colon cancer cells growing in the cecum ...
Robert B. Rebhun +5 more
doaj +1 more source