Results 41 to 50 of about 5,519,715 (191)

Clinical significance of VEGF-A, -C and -D expression in esophageal malignancies [PDF]

, 2005
Vascular endothelial growth factors ( VEGF)- A, - C and - D are members of the proangiogenic VEGF family of glycoproteins. VEGF-A is known to be the most important angiogenic factor under physiological and pathological conditions, while VEGF-C and VEGF-D
Jauch, Karl-Walter, Kleespies, A., Bruns, Christiane J.   +2 more
core   +1 more source

Conserved signaling through vascular endothelial growth (VEGF) receptor family members in murine lymphatic endothelial cells

, 2011
Lymphatic vessels guide interstitial fluid, modulate immune responses by regulating leukocyte and antigen trafficking to lymph nodes, and in a cancer setting enable tumor cells to track to regional lymph nodes.
Williams, Elizabeth D., Coso, Sanja, Zeng, Yiping, Elizabeth D. Williams, Sooraj, Dhanya, Yiping Zeng, Dhanya Sooraj, Sanja Coso   +7 more
core   +2 more sources

Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment. [PDF]

PLoS ONE, 2014
Peripheral self-tolerance eliminates lymphocytes specific for tissue-specific antigens not encountered in the thymus. Recently, we demonstrated that lymphatic endothelial cells in mice directly express peripheral tissue antigens, including tyrosinase ...
Jarish N Cohen, Eric F Tewalt, Sherin J Rouhani, Erica L Buonomo, Amber N Bruce, Xiaojiang Xu, Stefan Bekiranov, Yang-Xin Fu, Victor H Engelhard   +8 more
doaj   +1 more source

Mobilization of lymphatic endothelial precursor cells and lymphatic neovascularization in primary Sjögren's syndrome [PDF]

Journal of Cellular and Molecular Medicine, 2016
AbstractAlthough lymphatic neovascularization may be a key feature of chronic inflammation, it is almost unexplored in primary Sjögren's syndrome (pSS). A recent study revealed a pro‐lymphangiogenic function of interleukin (IL)‐17, a leading player in pSS pathogenesis.
Alunno, Alessia, Ibba, Lidia, Bistoni, Onelia, Rosa, Irene, Caterbi, Sara, Gerli, Roberto, Manetti, Mirko   +6 more
openaire   +5 more sources

Angiogenic potential of endothelial progenitor cells and embryonic stem cells [PDF]

, 2011
Background: Endothelial progenitor cells (EPCs) are implicated in a range of pathological conditions, suggesting a natural therapeutic role for EPCs in angiogenesis.
Kelly, RDW, Stuart Egginton, Rae, Peter, Richard DW Kelly, StJohn, JC, Peter C Rae, St. John, Justin C., Justin C St John, Rae, Peter C., Egginton, Stuart, Rae, PC, Egginton, S, Kelly, Richard D. W., St John, JC   +13 more
core   +1 more source

Constitutive Expression of the α4 Integrin Correlates with Tumorigenicity and Lymph Node Metastasis of the B16 Murine Melanoma

Neoplasia: An International Journal for Oncology Research, 2010
The lymphatic system plays a critical role in melanoma metastasis, and yet, virtually no information exists regarding the cellular and molecular mechanisms that take place between melanoma cells and the lymphatic vasculature.
Robert B. Rebhun, Hua Cheng, Jeffrey E. Gershenwald, Dominic Fan, Isaiah J. Fidler, Robert R. Langley   +5 more
doaj   +1 more source

Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration

Cell Reports, 2020
Summary: Regulatory T cells (Tregs) express high levels of cell surface lymphotoxin alpha beta (LTα1β2) to activate the LT beta receptor (LTβR) on the lymphatic endothelial cells (LECs), modulating LEC adhesion molecules, intercellular junctions, and ...
Wenji Piao, Yanbao Xiong, Lushen Li, Vikas Saxena, Kile D. Smith, Keli L. Hippen, Christina Paluskievicz, Marina Willsonshirkey, Bruce R. Blazar, Reza Abdi, Jonathan S. Bromberg   +10 more
doaj   +1 more source

Brugia malayi Asparaginyl-tRNA Synthetase Stimulates Endothelial Cell Proliferation, Vasodilation and Angiogenesis. [PDF]

PLoS ONE, 2016
A hallmark of chronic infection with lymphatic filarial parasites is the development of lymphatic disease which often results in permanent vasodilation and lymphedema, but all of the mechanisms by which filarial parasites induce pathology are not known ...
Jeeva Jothi D, Muthu Dhanraj, Shanmugam Solaiappan, Sanjana Sivanesan, Michael Kron, Anuradha Dhanasekaran   +5 more
doaj   +1 more source

Isolation and Characterization of Human Lung Lymphatic Endothelial Cells [PDF]

BioMed Research International, 2015
Characterization of lymphatic endothelial cells from the respiratory system may be crucial to investigate the role of the lymphatic system in the normal and diseased lung. We describe a simple and inexpensive method to harvest, isolate, and expand lymphatic endothelial cells from the human lung (HL-LECs).
LORUSSO, BRUNO, FALCO, Angela, MADEDDU, Denise, FRATI, Caterina, CAVALLI, Stefano, GRAIANI, Gallia, GERVASI, Andrea, RINALDI, LAURA, Lagrasta, Costanza, Maselli, Davide, Gnetti, Letizia, SILINI, Enrico Maria, Quaini, Eugenio, AMPOLLINI, Luca, CARBOGNANI, Paolo, QUAINI, Federico   +15 more
openaire   +4 more sources

VEGF family members : modulators of tumor angiogenesis and lymphangiogenesis [PDF]

, 2006
Members of the vascular endothelial growth factor (VEGF) family and their receptors (VEGFR) play an essential role in the development and maintenance of the blood and lymphatic vasculature.
Kopfstein, Lucie
core   +1 more source