Results 61 to 70 of about 107,605 (342)

A Mathematical Model for Lymphangiogenesis in Normal and Diabetic Wounds

, 2015
Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries.
Bianchi, Arianna, Painter, Kevin J., Sherratt, Jonathan A.   +2 more
core   +1 more source

A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo [PDF]

, 2012
In vivo imaging has revolutionized understanding of the spatiotemporal complexity that subserves the generation of successful effector and regulatory immune responses.
Andrea J. White, Butcher, Cardillo, Carragher, Catherine M. Rush, Celli, de Boer, Eric J. Jenkinson, Farr, Fulmer, Gianluca Grassia, Girard, Graham Anderson, Gunn, Hillebrands, Huang, Iain B. McInnes, Itano, James M. Brewer, Karen J. Bryson, Kono, Lane, Leishman, Luther, McNagny, Millington, Pasquale Maffia, Paul Garside, Proudman, Robert A. Benson, Schneider, Smith, Stutzmann, Sumen, Tammela, Tomei, Vivienne B. Gibson, White, Worbs, Yoshida, Zinselmeyer   +40 more
core   +2 more sources

A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis

Molecular Cancer, 2010
Background Lymph node metastasis constitutes a key event in tumor progression. The molecular control of this process is poorly understood. Heparan sulfate is a linear polysaccharide consisting of unique sulfate-modified disaccharide repeats that allow ...
Srinivasan R Sathish, Johns Scott C, Lawrence Roger, Truty Jadwiga, Yin Xin, Handel Tracy M, Fuster Mark M   +6 more
doaj   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Human Lymphatic Endothelial Cells Express Multiple Functional TLRs [PDF]

The Journal of Immunology, 2008
Abstract The lymphatic endothelium is the preferred route for the drainage of interstitial fluid from tissues and also serves as a conduit for peripheral dendritic cells (DCs) to reach draining lymph nodes. Lymphatic endothelial cells (LECs) are known to produce chemokines that recruit Ag-loaded DCs to lymphatic vessels and therefore are
Amarendra, Pegu, Shulin, Qin, Beth A, Fallert Junecko, Riccardo E, Nisato, Michael S, Pepper, Todd A, Reinhart   +5 more
openaire   +2 more sources

VEGFR3 is required for button junction formation in lymphatic vessels

Cell Reports, 2023
Summary: Lymphatic capillaries develop discontinuous cell-cell junctions that permit the absorption of large macromolecules, chylomicrons, and fluid from the interstitium.
Melanie Jannaway, Drishya Iyer, Diandra M. Mastrogiacomo, Kunyu Li, Derek C. Sung, Ying Yang, Mark L. Kahn, Joshua P. Scallan   +7 more
doaj   +1 more source

Spatio-temporal Models of Lymphangiogenesis in Wound Healing

, 2016
Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries.
A Bianchi, A Castiglioni, A Christiansen, A Friedman, A Gosiewska, A Louveau, A Mantovani, A Saaristo, A Stéphanou, AB Sutton, AI Papaioannou, AJ Macdonald, AJ Singer, Arianna Bianchi, AV Benest, AW Taylor, AY Sheikh, B Greenwood, B Kaminska, B Whitehurst, BE Farrell, BM Berg van den, C Cao, C Heppell, C Norrmen, CA Cobbold, CH Cho, CL Helm, CT Ambrose, D Ludwig, DJ Grainger, DR Brown, E Hormbrey, E Mendoza, EK Rofstad, ETT Withington, F Krombach, F Mac Gabhann, G Crescenzo De, G Müller, G Oliver, GF Pierce, GJ Goodhill, H Brem, H Kaur, H Staden von, HA Levine, HM Byrne, HM Byrne, HV Waugh, I Barkefors, I Choi, I Nunes, I Zachary, J Asai, J Goldman, J Posnett, JA Flegg, JC Zhuang, JD Shields, JF Douglas, JJL Velázquez, JJL Velázquez, JM Rutkowski, JM Rutkowski, Jonathan A. Sherratt, JP Yang, K Maruyama, K Weber-Matthiesen, KC Boardman, KE Murphy, Kevin J. Painter, KN Margaris, L Edelstein, L Yang, LM Wakefield, M Fischer, M Hyytiäinen, M Lohela, M Oi, M Scianna, M Shi, MAJ Chaplain, ME Fleury, ME Swift, MH Witte, MTGT May, N Khalil, N Khalil, N Li Jeon, NP Reddy, NV Mantzaris, P Drew, P Galie, PN Bernatchez, R Boulton, R Huggenberger, RC Ji, RC Schugart, RH Adams, RS Sweat, RT Tranquillo, S Kiriakidis, S Lee, S Monstrey, S Podgrabinska, S Zimny, SJ Lunt, SM Wahl, T Miura, T Roose, T Tammela, TG Simonsen, TL Haas, VPKH Nguyen, WJ Jeffcoate, Y Cao, Y Zheng   +117 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro [PDF]

, 2017
Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microenvironment are linked to the presence of LVI and angiogenesis.
Ahmad, Narmeen, El-Refaee, Mohammed, Jackson, Andrew M., Martin, Stewart G., Safuan, Sabreena, Storr, Sarah J.   +5 more
core   +2 more sources

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source