Results 71 to 80 of about 107,605 (342)

Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells [PDF]

Angiogenesis, 2013
Radiation therapy after lymph node dissection increases the risk of developing painful and incurable lymphedema in breast cancer patients. Lymphedema occurs when lymphatic vessels become unable to maintain proper fluid balance. The sensitivity of lymphatic endothelial cells (LECs) to ionizing radiation has not been reported to date.
Cristina T, Kesler, Angera H, Kuo, Hon-Kit, Wong, David J, Masuck, Jennifer L, Shah, Kevin R, Kozak, Kathryn D, Held, Timothy P, Padera   +7 more
openaire   +2 more sources

KSHV Induction of Angiogenic and Lymphangiogenic Phenotypes

Frontiers in Microbiology, 2012
Kaposi’s Sarcoma is a highly vascularized tumor supporting large amounts of neo-angiogenesis. The major cell type in KS tumors is the spindle cell, a cell that expresses markers of lymphatic endothelium. KSHV, the etiologic agent of KS, is found in the
Terri A. DiMiao, Michael eLagunoff
doaj   +1 more source

Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway [PDF]

, 2016
BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory disorders.
Blacher, S., García-Caballero, Melissa, Medina, Miguel Ángel, Nöel, Agnes, Pauper, J., Quesada, Ana R.   +5 more
core  

Structure and age-dependent development of the turkey liver: a comparative study of a highly selected meat-type and a wild-type turkey line [PDF]

, 2019
In this study the macroscopic and microscopic structure of the liver of a fast growing, meat-type turkey line (British United turkeys BUT Big 6, n = 25) and a wild-type turkey line (Wild Canadian turkey, n = 48) were compared at the age of 4, 8, 12, 16 ...
Custodis, Pia, Gemeinhardt, Ole, Hafez, Hafez Mohamed, Hirschberg, Ruth M., Hünigen, Hana, Mainzer, Kathleen, Masri, Salah Al, Plendl, Johanna, Richardson, Kenneth C.   +8 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development [PDF]

, 2017
The lymphatic system controls fluid homeostasis and the clearance of macromolecules from interstitial compartments. In mammals brain lymphatics were only recently discovered, with significant implications for physiology and disease. We examined zebrafish
Hawkins, TA, Rihel, J, Schulte-Merker, S, Shibata-Germanos, S, Van Impel, A, Van Lessen, M   +5 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Single-cell RNA sequencing reveals cellular and molecular landscape of fetal cystic hygroma

BMC Medical Genomics
Background The molecular mechanism of fetal cystic hygroma (CH) is still unclear, and no study has previously reported the transcriptome changes of single cells in CH.
Fang Fu, Xin Yang, Ru Li, Yingsi Li, Hang Zhou, Ken Cheng, Ruibin Huang, You Wang, Fei Guo, Lina Zhang, Min Pan, Jin Han, Li Zhen, Lushan Li, Tingying Lei, Dongzhi Li, Can Liao   +16 more
doaj   +1 more source

Reconstruction of lymphatic vessels in the mouse tail after cupping therapy

Folia Morphologica, 2020
Background: The aim of the study was to investigate the regulatory mechanism of local lymphatic reconstruction after cupping therapy in a mouse model. Materials and methods: The lymphatic reconstruction process in the mouse tail after cupping therapy as ...
F.-W. Meng, Z.-L. Gao, L. Li, L.-L. Jie, P.-F. Yang, Z. Liang, Y.-W. Gao, W.-H. Liu   +7 more
doaj   +1 more source