Results 71 to 80 of about 5,519,715 (191)

Lymphangiogenesis in breast carcinoma is present but insufficient for metastatic spread

Journal of Health Sciences, 2014
Introduction: The lymphatic vasculature is an important route for the metastatic spread of human cancer. However, the extent to which this depends on lymphangiogenesis or on invasion of existing lymph vessels remains controversial. The goal of this study
Mirsad Dorić, Suada Kuskunović-Vlahovljak, Svjetlana Radović, Ajna Hukić, Mirsad Babić, Edina Lazović-Salčin   +5 more
doaj   +1 more source

The phosphodiesterase 2A regulates lymphatic endothelial development via cGMP-mediated control of Notch signaling

, 2023
During vascular development endothelial junctions mature and vessel integrity is established to form the endothelial barrier. The molecular mechanisms by which lymphatic vessels induce cell contact inhibition are not understood. Here, we uncover the cGMP-
Silvia Cardarelli, Viacheslav O Nikolaev, Manuela Pellegrini, Sandra A Hemkemeyer, Danny Schreier, Ceren Saygi, Christian Schulte, Thomas Renné, Maike Frye, Leon Liekfeld, Fabio Naro, Joanna Kalucka, Reiner Mailer, Roberta Kurelic, Tilman Schäffer, Claudia Carlantoni, Manu Beerens   +16 more
core  

The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function

, 2021
Hogan and colleagues report that the RNA helicase Ddx21 mediates Vegfc-stimulated lymphangiogenesis during zebrafish development through controlling rDNA transcription and ribosome biogenesis in endothelial cells.
Mason, Elizabeth,, Leshchiner, Ignaty,, Dudczig, Stefanie,, Paterson, Scott,, Lagendijk, Anne Karine,, Arnold, Hannah,, Skoczylas, Renae,, Gloger, Marleen,, Xuan, Jiachen,, Chen, Huijun,, Rondon-Galeano, Maria,, Goessling, Wolfram,, Baillie, Gregory J.,, Schulte-Merker, Stefan,, Koltowska, Katarzyna,, Bower, Neil I.,, Sanij, Elaine,, Simons, Cas,, Heath, Joan K.,, Smith, Kelly A.,, Pearson, Richard B.,, Hogan, Benjamin M.,, Okuda, Kazuhide S.,   +22 more
core   +1 more source

Modelling the fluid drainage through primary lymphatic valves

, 2013
This study investigates the fluid flow through tissues where lymphatic drainage occurs. Lymphatic drainage relies on two unidirectional valve systems, primary and secondary.
Heppell, Charles
core   +1 more source

Further characterisation of immortalised human lymphatic endothelial cells to explore their transcriptomic profile and VEGFC response

Scientific Reports
In vitro modelling relies on the availability of suitable cell types that accurately represent the organs under study. In lymphatic research, human dermal lymphatic endothelial cells represent the “gold standard”, even though they lose their identity and
Kazim Ogmen, Ruby Moy, Sara E. Dobbins, Lotte van den Bent, Onno Kranenburg, Jeroen Hagendoorn, Alan Pittman, Pia Ostergaard, Silvia Martin-Almedina   +8 more
doaj   +1 more source

Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation

eLife, 2020
Mutations in the transcription factor FOXC2 are predominately associated with lymphedema. Herein, we demonstrate a key role for related factor FOXC1, in addition to FOXC2, in regulating cytoskeletal activity in lymphatic valves.
Pieter R Norden, Amélie Sabine, Ying Wang, Cansaran Saygili Demir, Ting Liu, Tatiana V Petrova, Tsutomu Kume   +6 more
doaj   +1 more source

Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein

, 2011
The homeobox transcription factor PROX1 is essential for the development and maintenance of lymphatic vasculature. How PROX1 regulates lymphatic endothelial cell fate remains undefined. PROX1 has been shown to upregulate the expression of Cyclin E, which
Hae K. Kim, Bocangel, Patricia,, Jaganmohan R. Jangamreddy, Douville, Josette M.,, Baxtera, Shannon A.,, Shannon A. Baxter, Wigle, Jeffrey T.,, Zhang, Shunzhen,, Josette M. Douville, David D. Eisenstat, Cheung, David Y.,, Krista Herbert, Patricia Bocangel, David Y. Cheung, Eisensta, David D.,, Shunzhen Zhang, Herbert, Krista,, Jeffrey T. Wigle, Kim, Hae K.,, Jangamreddy, Jaganmohan Reddy,   +19 more
core   +1 more source

A Case of Abnormal Lymphatic-Like Differentiation and Endothelial Progenitor Cell Activation in Neovascularization Associated with Hemi-Retinal Vein Occlusion

Case Reports in Ophthalmology, 2015
Purpose: Pathological vascular differentiation in retinal vein occlusion (RVO)-related neovessel formation remains poorly characterized. The role of intraocular lymphatic-like differentiation or endothelial progenitor cell activity has not been studied ...
Sirpa Loukovaara, Erika Gucciardo, Pauliina Repo, Jouko Lohi, Petri Salven, Kaisa Lehti   +5 more
doaj   +1 more source

A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature

Frontiers in Cardiovascular Medicine, 2020
Single-cell transcriptomics promise to revolutionize our understanding of the vasculature. Emerging computational methods applied to high-dimensional single-cell data allow integration of results between samples and species and illuminate the diversity ...
Menglan Xiang, Menglan Xiang, Menglan Xiang, Rubén Adrián Grosso, Akira Takeda, Junliang Pan, Junliang Pan, Tove Bekkhus, Kevin Brulois, Kevin Brulois, Denis Dermadi, Denis Dermadi, Sofia Nordling, Sofia Nordling, Sofia Nordling, Michael Vanlandewijck, Michael Vanlandewijck, Sirpa Jalkanen, Maria H. Ulvmar, Eugene C. Butcher, Eugene C. Butcher, Eugene C. Butcher   +21 more
doaj   +1 more source

Regulation of VEGFR3 signaling in lymphatic endothelial cells

Frontiers in Cell and Developmental Biology
The receptor tyrosine kinase vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3) is the principal transmembrane receptor responsible for sensing and coordinating cellular responses to environmental lymphangiogenic stimuli in lymphatic endothelial cells (LECs).
Kevin G. Kuonqui, Adana-Christine Campbell, Bracha L. Pollack, Jinyeon Shin, Ananta Sarker, Stav Brown, Hyeung Ju Park, Babak J. Mehrara, Raghu P. Kataru   +8 more
openaire   +3 more sources