Results 51 to 60 of about 5,519,715 (191)

Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

Nature Communications, 2018
Mechanical cues are known to influence endothelial cell behavior. Here Frye et al. show that lymphatic endothelial cell progenitors experience varying degrees of matrix stiffness during development, and that matrix stiffness regulates GATA2 expression to
Maike Frye, Andrea Taddei, Cathrin Dierkes, Ines Martinez-Corral, Matthew Fielden, Henrik Ortsäter, Jan Kazenwadel, Dinis P. Calado, Pia Ostergaard, Marjo Salminen, Liqun He, Natasha L. Harvey, Friedemann Kiefer, Taija Mäkinen   +13 more
doaj   +1 more source

Planar cell polarity protein Celsr1 regulates endothelial adherens junctionsand directed cell rearrangements during lymphatic valve morphogenesis.

, 2013
Planar cell polarity (PCP) signaling controls tissue morphogenesis by coordinating collective cell behaviours. Here we show a critical role for the core PCP proteins Celsr1 and Vangl2 in the complex morphogenetic process of intraluminal valve formation ...
Devenport, Danelle, Weston, Anne, Taddei, Andrea, Makinen, Taija, Mäkinen, Taija,, Davenport, Danelle, Fuchs, Elaine, Tatin, Florence, Tissir, Fadel   +8 more
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Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling [PDF]

, 2017
The signaling proteins and pathways involved in lymphatic endothelial cell migration are identified through a functional screen.
Harris, Nicole C., Resnick, Daniel, Sophie Paquet-Fifield, Gordon K. Smyth, Hogan, Benjamin M., Leigh Coultas, Stacker, Steven A., Simpson, Kaylene J., Smyth, Gordon K., Mueller, Scott N., Walter, Anne, Adam F. Odell, Liu, Ruofei, Daniel Resnick, Stephen B. Fox, Benjamin M. Hogan, Gould, Cathryn M., Gregory, Julia L., Cathryn M. Gould, Jason Li, Takano, Elena A., Anne Walter, Karnezis, Tara, Sara F. Lamont, Bower, Neil I., Kaylene J. Simpson, Fox, Stephen B., Marc G. Achen, Elena A. Takano, Williams, Steven P., Odell, Adam, Lamont, Sara F., Cameron J. Nowell, Rae H. Farnsworth, Achen, Marc G., Ruofei Liu, Nowell, Cameron J., Steven A. Stacker, Li, Jason, Farnsworth, Rae H., Paquet-Fifield, Sophie, Coultas, Leigh, Scott N. Mueller, Tara Karnezis, Nicole C. Harris, Julia L. Gregory, Steven P. Williams, Neil I. Bower   +47 more
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A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis

Molecular Cancer, 2010
Background Lymph node metastasis constitutes a key event in tumor progression. The molecular control of this process is poorly understood. Heparan sulfate is a linear polysaccharide consisting of unique sulfate-modified disaccharide repeats that allow ...
Srinivasan R Sathish, Johns Scott C, Lawrence Roger, Truty Jadwiga, Yin Xin, Handel Tracy M, Fuster Mark M   +6 more
doaj   +1 more source

Basal cell carcinoma stroma as a mimicker of lymphatic invasion: A case report

SAGE Open Medical Case Reports, 2020
Basal cell carcinoma metastases are rare. We report a case of an 83 year-old male with recurrent cutaneous infiltrative basal cell carcinoma on the right vertex with tumor aggregates of infiltrative basal cell carcinoma in the lymphatic vessels of the ...
Marco Caruana, Meggie Morand, Annie Belisle, Mélissa Nantel-Battista   +3 more
doaj   +1 more source

Endothelial Microparticle-Mediated Transfer of microRNA-19b Inhibits the Function and Distribution of Lymphatic Vessels in Atherosclerotic Mice

Frontiers in Physiology, 2022
In recent years, the function of the lymphatic system in atherosclerosis has attracted attention due to its role in immune cell trafficking, cholesterol removal from the periphery, and regulation of the inflammatory response.
Shi-Ran Yu, Yu-Xia Cui, Zi-Qi Song, Su-Fang Li, Chun-Ying Zhang, Jun-Xian Song, Hong Chen   +6 more
doaj   +1 more source

Reversible trans-differentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro [PDF]

, 2010
Blood vascular cells and lymphatic endothelial cells (BECs and LECs, respectively) form two separate vascular systems and are functionally distinct cell types or lineages with characteristic gene expression profiles.
Thompson, Erik W., Ernst Pöschl, Lafleur, Marc A., Handsley, M. M., Lindsay S. Cooley, Pennington, C. J., Dylan R. Edwards, Edwards, Dylan R., Edwards, D. R., Pöschl, Ernst, Madeleine M. Handsley, Zhigang Zhou, Pöschl, E., Erik W. Thompson, Caroline J. Pennington, Lafleur, M. A., Zhou, Zhigang, Cooley, Lindsay S., Pennington, Caroline J., Zhou, Z., Handsley, Madeleine M., Cooley, L. S., Marc A. Lafleur   +22 more
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Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation

, 2012
Active lymph transport relies on smooth muscle cell (SMC) contractions around collecting lymphatic vessels, yet regulation of lymphatic vessel wall assembly and lymphatic pumping are poorly understood.
Lutter, Sophie, Xie, Sherry, Mäkinen, Taija, Tatin, Florence   +3 more
core   +1 more source

KSHV Induction of Angiogenic and Lymphangiogenic Phenotypes

Frontiers in Microbiology, 2012
Kaposi’s Sarcoma is a highly vascularized tumor supporting large amounts of neo-angiogenesis. The major cell type in KS tumors is the spindle cell, a cell that expresses markers of lymphatic endothelium. KSHV, the etiologic agent of KS, is found in the
Terri A. DiMiao, Michael eLagunoff
doaj   +1 more source

Regulation of lymphatic-blood vessel separation by endothelial Rac1 [PDF]

, 2009
Sprouting angiogenesis and lymphatic-blood vessel segregation both involve the migration of endothelial cells, but the precise migratory molecules that govern the decision of blood vascular endothelial cells to segregate into lymphatic vasculature are ...
Hodivala-Dilke, Kairbaan M., Robinson, Stephen D, Martinez Garcia, Maria Dolores, Thomas, Gareth J, Aubyn, Deborah, Sapienza, Karen, Ramjuan, Antoine R., Davies, Derek, Robinson, Stephen D., Jones, Dylan T, Spencer-Dene, Bradley, Martinez, Dolores, Zicha, Daniel, D'Amico, Gabriela, Thomas, Gareth J., Tybulewicz, Victor, Reynolds, Louise E., Ramjuan, Antoine R, Jones, Dylan T., Nye, Emma, Grose, Richard, Kostourou, Vassiliki, Hodivala-Dilke, Kairbaan M, Reynolds, Louise E   +23 more
core   +1 more source