Results 51 to 60 of about 23,756 (251)

Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis

International Journal of Cell Biology, 2012
In the 1970s, the late Judah Folkman postulated that tumors grow proportionately to their blood supply and that tumor angiogenesis removed this limitation promoting growth and metastasis. Work over the past 40 years, varying from molecular examination to
Jie Chen, J. Steven Alexander, A. Wayne Orr   +2 more
doaj   +1 more source

Lymphangiogenesis and Lesion Heterogeneity in Interstitial Lung Diseases

Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 2015
The lymphatic system has several physiological roles, including fluid homeostasis and the activation of adaptive immunity by fluid drainage and cell transport. Lymphangiogenesis occurs in adult tissues during various pathologic conditions.
Masahiro Yamashita
doaj   +1 more source

Corneal Lymphangiogenesis: Current Pathophysiological Understandings and Its Functional Role in Ocular Surface Disease

International Journal of Molecular Sciences, 2021
The cornea is a transparent and avascular tissue that plays a central role in light refraction and provides a physical barrier to the external environment.
H. Lee, Sang-Mok Lee, Dong-Ihll Lee
semanticscholar   +1 more source

Lymphangioblasts in Embryonic Lymphangiogenesis

Lymphatic Research and Biology, 2003
The origin of the lymphatic endothelium, either from the venous system or mesenchymal lymphangioblasts, presents as a persistent controversy. Recently, highly specific markers of the lymphatic endothelium have been found, enabling us to reinvestigate the embryonic origin of the lymphatics.The homeobox transcription factor, Prox1, is expressed in ...
Wilting, Jörg, Tomarev, Stanislav I., Christ, Bodo, Schweigerer, Lothar   +3 more
openaire   +4 more sources

Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells

Nature Communications, 2019
There are no conventional lymphatic vessels within the CNS parenchyma, although it has been hypothesized that lymphatics near the cribriform plate or dura maintain fluid homeostasis and immune surveillance during steady-state conditions.
Martin Hsu, A. Rayasam, Julie A. Kijak, Y. Choi, J. Harding, S. Marcus, W. Karpus, M. Sandor, Z. Fabry   +8 more
semanticscholar   +1 more source

Angiogenesis and Lymphangiogenesis in Medulloblastoma Development

Biology, 2023
Medulloblastoma (MB) is the most prevalent brain tumor in children. Although the current cure rate stands at approximately 70%, the existing treatments that involve a combination of radio- and chemotherapy are highly detrimental to the patients’ quality of life.
Penco-Campillo, Manon, Pages, Gilles, Martial, Sonia   +2 more
openaire   +4 more sources

Cellular and molecular mediators of lymphangiogenesis in inflammatory bowel disease

Journal of Translational Medicine, 2021
Background Recent studies reporting the intricate crosstalk between cellular and molecular mediators and the lymphatic endothelium in the development of inflammatory bowel diseases (IBD) suggest altered inflammatory cell drainage and lymphatic ...
D. K. W. Ocansey, Bing Pei, Xinwei Xu, Lu Zhang, C. V. Olovo, Fei Mao   +5 more
semanticscholar   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer

Advanced Science, EarlyView.
Single‐cell RNA sequencing of lymph node (LN) samples is performed, and a comprehensive landscape of the entire ecosystem is generated. Paracrine orchestration of TME remodeling induced by GLO1 potentiates LN metastasis in breast cancer. This study offers novel perspectives on the microenvironment remodeling of breast cancer LN metastases, suggesting ...
Jindong Xie, Wenjian Liu, Xinpei Deng, Huan Wang, Xueqi Ou, Xin An, Min‐Yi Situ, Anli Yang, Chuan Peng, Rongfang He, Yi Xie, Hailin Tang, Yuman Chen, Jie‐Ying Liang, Ruonan Shao, Weikai Xiao, Shaoquan Zheng   +16 more
wiley   +1 more source

Radiogenic Lymphangiogenesis in the Skin [PDF]

The American Journal of Pathology, 2007
The time course of microvascular changes in the environment of irradiated tumors was studied in a standardized human protocol. Eighty skin biopsies from 40 patients with previously treated primary breast cancer were taken from irradiated skin and corresponding contralateral unirradiated control areas 2 to 8 weeks, 11 to 14 months, or 17+ months after ...
Matthias Janusch, Eva J. Ulbrich, Peter Helmbold, Peter Helmbold, Dontscho Kerjaschki, Eckhard Fiedler, Jürgen Dunst, Jürgen Dunst, Wolfgang Ch. Marsch, Susanne Jackowski, Gabriele Gaisbauer   +10 more
openaire   +3 more sources