Results 51 to 60 of about 16,311 (176)

δ-Catenin activates Rho GTPase, promotes lymphangiogenesis and growth of tumor metastases. [PDF]

PLoS ONE, 2015
δ-Catenin, an adherens junctions protein, is not only involved in early development, cell-cell adhesion and cell motility in neuronal cells, but it also plays an important role in vascular endothelial cell motility and pathological angiogenesis.
Sampa Ghose, Yongfen Min, P Charles Lin
doaj   +1 more source

A Mathematical Model for Lymphangiogenesis in Normal and Diabetic Wounds [PDF]

arXiv, 2015
Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries. Although many mathematical models have been developed to describe the formation of blood capillaries (angiogenesis) very few have been proposed for the regeneration of the lymphatic ...
arxiv  

Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis

Cell Reports, 2019
Summary: Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebrate organs, lymphatic vessels display organotypic function and develop in an organ-specific manner. In all settings,
Adam J. Vogrin, Neil I. Bower, Menachem J. Gunzburg, Sally Roufail, Kazuhide S. Okuda, Scott Paterson, Stephen J. Headey, Steven A. Stacker, Benjamin M. Hogan, Marc G. Achen   +9 more
doaj  

circDHTKD1 promotes lymphatic metastasis of bladder cancer by upregulating CXCL5

Cell Death Discovery, 2022
Lymph node (LN) metastasis is associated with unfavorable prognosis of bladder cancer (BCa). Although lymphangiogenesis is functionally important in LN metastasis of tumors, the potential mechanism in BCa remains unclear.
Qun Lu, Haoli Yin, Yongming Deng, Wei Chen, Wenli Diao, Meng Ding, Wenmin Cao, Yao Fu, Wenjing Mo, Xiaoqing Chen, Qing Zhang, Xiaozhi Zhao, Hongqian Guo   +12 more
doaj   +1 more source

Intraoperative methylene blue staining is effective as a single mapping technique in the identification of sentinel lymph nodes in dogs with low‐grade mast cell tumours

Journal of Small Animal Practice, EarlyView.
Objectives The aim of this prospective study was to assess the association between methylene blue staining pattern and the presence of histologic nodal metastasis in dogs with low‐grade mast cell tumour in low‐resource settings for the efficient diagnosis of lymphatic spread.
S. Zanardi, D. Guerra, S. Sabattini, A. Foglia, S. Del Magno, V. Cola, L. Pisoni, L. Ciammaichella, E. Faroni, C. Agnoli, A. Renzi, L. Marconato   +11 more
wiley   +1 more source

Defective lymphatic vasculature in obesity

Obesity Reviews, EarlyView.
Summary Lymphedema is an important, and often underdiagnosed complication of obesity and is likely due to acquired defects in the lymphatic vasculature. Study of diet‐induced obesity animal models have indicated defective lymphatic vasculatures might extend to other anatomical sites, especially visceral depots.
Jingjing Zhu, John P. H. Wilding, Ji Hu
wiley   +1 more source

RAS Pathway Mutations and Therapeutics in Vascular Anomalies

Pediatric Blood &Cancer, Volume 72, Issue 5, May 2025.
ABSTRACT Vascular anomalies (VAs) are a diverse group of vascular tumors and vascular malformations (VMs). VMs are characterized by abnormal vessel development, overgrowth, and dysfunction. Coagulopathy, edema, and effusions can cause severe morbidity and mortality in children and adults with these diseases. Germline or somatic mutations in the RAS/RAF/
Sara Alharbi, Svatava Merkle, Adrienne M. Hammill, Andrew M. Waters, Timothy D. Le Cras   +4 more
wiley   +1 more source

Adenosine A2a receptor promotes lymphangiogenesis and lymph node metastasis

OncoImmunology, 2019
The formation of new lymphatic vessels, or lymphangiogenesis, is a critical step of the tissue repair program. In pathological conditions involving chronic inflammation or tumorigenesis, this process is often dysregulated and can contribute to disease ...
Bertrand Allard, Isabelle Cousineau, David Allard, Laurence Buisseret, Sandra Pommey, Pavel Chrobak, John Stagg   +6 more
doaj   +1 more source

Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer

World Journal of Surgical Oncology, 2017
Background Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer.
Jiabu Tang, Zheng Yang, Zhuo Wang, Zhen Li, Hongmei Li, Jinbao Yin, Min Deng, Wei Zhu, Chao Zeng   +8 more
doaj   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source