Results 71 to 80 of about 16,311 (176)

Microglial Depletion, a New Tool in Neuroinflammatory Disorders: Comparison of Pharmacological Inhibitors of the CSF‐1R

Glia, Volume 73, Issue 4, Page 686-700, April 2025.
Main Points Microglial survival relies on CSF‐1R signaling, which can be inhibited pharmacologically. CSF‐1R inhibitors deplete microglia and reduce neuroinflammation in neurodegenerative models. Effects on other CNS during neurodevelopment are unclear.
David Guenoun, Nathan Blaise, Alexandre Sellam, Julie Roupret‐Serzec, Alice Jacquens, Juliette Van Steenwinckel, Pierre Gressens, Cindy Bokobza   +7 more
wiley   +1 more source

Lymphatics and Lymphangiogenesis in the Eye

Journal of Ophthalmology, 2012
Lymphatic is a prerequisite for the maintenance of tissue fluid balance and immunity in the body. A body of evidence also shows that lymphangiogenesis plays important roles in the pathogenesis of diseases such as tumor metastasis and inflammation.
Shintaro Nakao, Ali Hafezi-Moghadam, Tatsuro Ishibashi   +2 more
doaj   +1 more source

Phomaketide A Inhibits Lymphangiogenesis in Human Lymphatic Endothelial Cells

Marine Drugs, 2019
Lymphangiogenesis is an important biological process associated with cancer metastasis. The development of new drugs that block lymphangiogenesis represents a promising therapeutic strategy. Marine fungus-derived compound phomaketide A, isolated from the
Huai-Ching Tai, Tzong-Huei Lee, Chih-Hsin Tang, Lei-Po Chen, Wei-Cheng Chen, Ming-Shian Lee, Pei-Chi Chen, Chih-Yang Lin, Chih-Wen Chi, Yu-Jen Chen, Cheng-Ta Lai, Shiou-Sheng Chen, Kuang-Wen Liao, Chien-Hsing Lee, Shih-Wei Wang   +14 more
doaj   +1 more source

Lysyl Oxidase-Like Protein 2 Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer

Neoplasia: An International Journal for Oncology Research, 2019
Tumor lymphangiogenesis has been previously documented to predict regional lymph node metastasis and promote the spread to distant organs. However, the underlying mechanism initiating tumor lymphangiogenesis remains unclear.
Chunying Wang, Siran Xu, Yang Tian, Anji Ju, Qiaoyun Hou, Jie Liu, Yan Fu, Yongzhang Luo   +7 more
doaj  

Lymphangiogenesis and lymphangiodysplasia: From molecular to clinical lymphology [PDF]

, 2001
Marlys H. Witte, Michael Bernas, Clifford P. Martin, Charles L. Witte   +3 more
openalex   +1 more source

The Adverse Impact of Tyrosine Kinase Inhibitors on Wound Healing and Repair

International Wound Journal, Volume 22, Issue 4, April 2025.
ABSTRACT Tyrosine kinase inhibitors (TKIs) can treat various cancers, primarily through their antiangiogenic effects. However, as angiogenesis is crucial for successful wound healing, TKIs may adversely impact wound repair. This review analysed all 63 FDA‐approved TKIs and identified evidence for wound healing and repair implications in 24 agents.
William J. Nahm, Vincent Falanga
wiley   +1 more source

Systematic review: The gut microbiota as a link between colorectal cancer and obesity

Obesity Reviews, Volume 26, Issue 4, April 2025.
Summary Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer.
Antonio Jesús Ruiz‐Malagón, María Jesús Rodríguez‐Sojo, Eduardo Redondo, María Elena Rodríguez‐Cabezas, Julio Gálvez, Alba Rodríguez‐Nogales   +5 more
wiley   +1 more source

Concurrent Induction of Lymphangiogenesis, Angiogenesis, and Macrophage Recruitment by Vascular Endothelial Growth Factor-C in Melanoma [PDF]

, 2001
Mihaela Skobe, Leena M. Hamberg, Thomas Hawighorst, Michael Schirner, Gerald Wolf, Kari Alitalo, Michael Detmar   +6 more
openalex   +1 more source

Numerical analysis of the cross-diffusion Cahn-Hilliard model in lymphangiogenesis [PDF]

arXiv
In this paper, a fully discrete finite element numerical scheme with a stabilizer for the cross-diffusion Cahn--Hilliard model arising in modeling the pre-pattern in lymphangiogenesis is proposed and analysed. The discrete energy dissipation stability and existence of the numerical solution for the scheme are proven.
arxiv  

The global landscape and research trend of lymphangiogenesis in breast cancer: a bibliometric analysis and visualization

Frontiers in Oncology
BackgroundBreast cancer persists as a major public health issue on a global scale. Lymphangiogenesis is an indispensable element in the promotion of breast cancer metastasis.
Liuyan Xu, Xuan Wang, Beibei Wang, Bingxin Meng, Xiaohua Pei   +4 more
doaj   +1 more source