Results 71 to 80 of about 43,762 (300)

A zebrafish model of inflammatory lymphangiogenesis

Biology Open, 2015
Inflammatory bowel disease (IBD) is a disabling chronic inflammatory disease of the gastrointestinal tract. IBD patients have increased intestinal lymphatic vessel density and recent studies have shown that this may contribute to the resolution of IBD ...
Kazuhide S. Okuda, June Pauline Misa, Stefan H. Oehlers, Christopher J. Hall, Felix Ellett, Sultan Alasmari, Graham J. Lieschke, Kathryn E. Crosier, Philip S. Crosier, Jonathan W. Astin   +9 more
doaj   +1 more source

Granulomatous inflammation in tuberculosis and sarcoidosis: does the lymphatic system contribute to disease? [PDF]

, 2019
A striking and unexplained feature of granulomatous inflammation is its anatomical association with the lymphatic system. Accumulating evidence suggests that lymphatic tracks and granulomas may alter the function of each other.
Gutierrez, Maximiliano G, Patterson, Karen C, Queval, Christophe J   +2 more
core   +1 more source

Lymphangiogenesis and cancer metastasis [PDF]

Journal of Cellular and Molecular Medicine, 2009
Abstract Anatomy and function of the lymphatic system Tumour‐induced lymphangiogenesis promotes metastasis Tumour‐induced lymph node lymphangiogenesis precedes cancer metastasis to lymph nodes Tumour cell invasion into lymphatic vessels Peri‐ and intra‐tumoral lymphangiogenesis Lymphatic vessel markers and lymphangiogenic growth factors Preventive and ...
Mumprecht, Viviane, Detmar, Michael
openaire   +2 more sources

Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells

Nature Communications, 2019
There are no conventional lymphatic vessels within the CNS parenchyma, although it has been hypothesized that lymphatics near the cribriform plate or dura maintain fluid homeostasis and immune surveillance during steady-state conditions.
Martin Hsu, A. Rayasam, Julie A. Kijak, Y. Choi, J. Harding, S. Marcus, W. Karpus, M. Sandor, Z. Fabry   +8 more
semanticscholar   +1 more source

Growth Hormone Promotes Lymphangiogenesis [PDF]

The American Journal of Pathology, 2008
The lymphatic system plays an important role in inflammation and cancer progression, although the molecular mechanisms involved are poorly understood. As determined using comparative transcriptional profiling studies of cultured lymphatic endothelial cells versus blood vascular endothelial cells, growth hormone receptor was expressed at much higher ...
Nadja Erika, Banziger-Tobler, Cornelia, Halin, Kentaro, Kajiya, Michael, Detmar   +3 more
openaire   +2 more sources

CEACAM1 increased the lymphangiogenesis through miR-423-5p and NF- kB in Non-Small Cell Lung Cancer

Biochemistry and Biophysics Reports
Background: Lung cancer causes significant mortality, with invasion and metastasis being the main features that cause most cancer deaths. Lymph node metastasis is the primary metastatic route in non-small cell carcinoma (NSCLC) and influences the staging
Jie Yu, Wenke Cai, Tao Zhou, Bo Men, Shunqiong Chen, Dong Tu, Wei Guo, Jicui Wang, Feipeng Zhao, Yan Wang   +9 more
doaj   +1 more source

Effects of adenosine on lymphangiogenesis. [PDF]

PLoS ONE, 2014
BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood but promotes tumor spread and metastasis during ...
Bénédicte Lenoir, Daniel R Wagner, Silvia Blacher, Graciela B Sala-Newby, Andrew C Newby, Agnès Noel, Yvan Devaux   +6 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

ADSCs enhance VEGFR3-mediated lymphangiogenesis via METTL3-mediated VEGF-C m6A modification to improve wound healing of diabetic foot ulcers

Molecular Medicine, 2021
Adipose-derived mesenchymal stem cells (ADSCs) are an important focus in regenerative medicine. However, the biological function of ADSCs in the wound repair of diabetic foot ulcers (DFUs) remains unclear.
Jie Zhou, Tianhong Wei, Zhiyou He
semanticscholar   +1 more source

Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats

Disease Models & Mechanisms, 2015
Proteinuria is an important cause of tubulointerstitial damage. Anti-proteinuric interventions are not always successful, and residual proteinuria often leads to renal failure.
Saleh Yazdani, Ryanne S. Hijmans, Fariba Poosti, Wendy Dam, Gerjan Navis, Harry van Goor, Jacob van den Born   +6 more
doaj   +1 more source