Results 71 to 80 of about 27,751 (253)

Focus on lymphangiogenesis in tumor metastasis [PDF]

Cancer Cell, 2005
M.G.A. and S.A.S. are supported by Senior Research Fellowships from the National Health and Medical Research Council of Australia (NHMRC) and the Pfizer Foundation, respectively, and by a Program Grant from the NHMRC. B.K.M. is a recipient of a Melbourne Research Scholarship from the University of Melbourne.
Steven A. Stacker, Bradley McColl, Marc G. Achen   +2 more
openaire   +3 more sources

WISP-3 Stimulates VEGF-C-Dependent Lymphangiogenesis in Human Chondrosarcoma Cells by Inhibiting miR-196a-3p Synthesis

Biomedicines, 2021
Chondrosarcoma is a malignant bone tumor with high metastatic potential. Lymphangiogenesis is a critical biological step in cancer metastasis. WNT1-inducible signaling pathway protein 3 (WISP-3) regulates angiogenesis and facilitates chondrosarcoma ...
Chih-Yang Lin, Shih-Wei Wang, Jeng-Hung Guo, Huai-Ching Tai, Wen-Chun Sun, Cheng-Ta Lai, Chen-Yu Yang, Shih-Chia Liu, Yi-Chin Fong, Chih-Hsin Tang   +9 more
doaj   +1 more source

Corneal Lymphangiogenesis: Current Pathophysiological Understandings and Its Functional Role in Ocular Surface Disease

International Journal of Molecular Sciences, 2021
The cornea is a transparent and avascular tissue that plays a central role in light refraction and provides a physical barrier to the external environment.
H. Lee, Sang-Mok Lee, Dong-Ihll Lee
semanticscholar   +1 more source

An LCN2‐Dependent Positive‐Feedback Loop Between Gastric Cancer Cells and Tumor‐Associated‐Macrophages Mediates Lymphangiogenesis and Lymphatic Metastasis

Advanced Science, EarlyView.
In this study, the expression and function of LCN2 in GC is aimed to investigate and elucidate the mechanisms by which the LCN2‐dependent positive‐feedback loop between GC cells and TAMs drives lymphangiogenesis and lymphatic metastasis. These findings suggest that LCN2 may serve as a potential prognostic biomarker and therapeutic target in GC ...
Zhixin Huang, Ying Li, Yan Qian, Linying Ye, Tianhao Zhang, Yang Cheng, Jialin Wu, Peng Duan, Tiantian Zhang, Zihan Yu, Zeyu Zhao, Risheng Zhao, Zhi Liang, Ertao Zhai, Shirong Cai, Jianhui Chen   +15 more
wiley   +1 more source

Angiogenesis and lymphangiogenesis in bronchial asthma [PDF]

Allergy, 2010
To cite this article: Detoraki A, Granata F, Staibano S, Rossi FW, Marone G, Genovese A. Angiogenesis and lymphangiogenesis in bronchial asthma. Allergy 2010; 65: 946–958.AbstractNeovascularization plays a prominent role in inflammation and tissue remodeling in several chronic inflammatory disorders.
Detoraki A., Granata F., STAIBANO, STEFANIA, ROSSI, FRANCESCA WANDA, MARONE, GIANNI, GENOVESE, ARTURO   +5 more
openaire   +4 more sources

Transient Ingrowth of Lymphatic Vessels into the Physiologically Avascular Cornea Regulates Corneal Edema and Transparency

Scientific Reports, 2017
Lymphangiogenesis is essential for fluid homeostasis in vascularized tissues. In the normally avascular cornea, however, pathological lymphangiogenesis mediates diseases like corneal transplant rejection, dry eye disease, and allergy.
Deniz Hos, Anne Bukowiecki, Jens Horstmann, Felix Bock, Franziska Bucher, Ludwig M. Heindl, Sebastian Siebelmann, Philipp Steven, Reza Dana, Sabine A. Eming, Claus Cursiefen   +10 more
doaj   +1 more source

Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection

Infection and Immunity, 2021
Vascular remodeling is a phenomenon seen in the cutaneous lesions formed during infection with Leishmania parasites. Within the lesion, Leishmania major infection leads to the infiltration of inflammatory cells, including macrophages, and is associated ...
Anne Bowlin, Hayden Roys, Humphrey Wanjala, Manjunath Bettadapura, Gopinath Venugopal, Jessica Surma, M. Simon, Tiffany Weinkopff   +7 more
semanticscholar   +1 more source

BACE2‐Induced Aberrant Lymphatic Network Aggravates the Local Inflammation in Arteriovenous Fistulas With Hyperphosphatemia

Advanced Science, EarlyView.
Vascular endothelial growth factor (VEGF)‐C secreted by Pi16+ fibro‐progenitors lays the foundation of lymphatic network in mouse arteriovenous fistulas (AVFs), whereas the elevated phosphate (Pi) in 5/6‐nephrectomy (Nx) mouse activates p‐ERK/p‐SP1/BACE2 pathway to generate additional soluble VEGFR‐3, which causes VEGF‐C unresponsiveness and defective ...
Kai Chen, Ziyin Guan, Hanwei Jin, Muladili Aihemaiti, Rong Mou, Mengting Yu, Yanhua Hu, Liujun Jiang, Xuliang Wang, Hao Yang, Ting Chen, Yao Lu, Hongkun Zhang, Qingbo Xu, Weidong Li   +14 more
wiley   +1 more source

NO‐Driven Janus Nanomotor Enhances T‐Cell Infiltration by Reconstructing Tumor‐Associated Blood and Lymphatic Vessels

Advanced Science, EarlyView.
NO‐driven hollow gold Janus nanomotors (HAM) are engineered to improve tumor blood vessel normalization throughout the entire tumor region to enhance T‐cell intratumoral infiltration, and generate and capture whole‐tumor antigens as an in situ cancer vaccine to enhance T‐cell activation, therefore enhancing the antitumor immune response.
Qingping Ma, Shunli Fu, Yiming Xia, Shuying Gao, Zhenxing Xia, Panpan Gu, Shijun Yuan, Jinhu Liu, Shuang Liang, Nan Li, Qinglin Yang, Weiwei Mu, Jie Liu, Xinrui Liu, Yongjun Liu, Na Zhang   +15 more
wiley   +1 more source

Lymphangiogenesis and cancer metastasis

Frontiers in Bioscience, 2011
Lymphangiogenesis remains a fascinating biological process that plays a crucial role in both normal tissue development and several lymphatic diseases. The last few years have witnessed a rapid progression in understanding the development and regulation of the lymphatic system which provided insight on several pathological processes including cancer ...
A. A. Mahir Al-Rawi, Wen Guo Jiang
openaire   +2 more sources