Results 71 to 80 of about 33,222 (220)
Advanced Science, EarlyView.The study develops engineered exosomes (EmDEX@GA) for locoregional immunomodulation of tumor‐draining lymph node (TDLN). EmDEX@GA can actively target to TDLN and remodel its immunosuppressive microenvironment through the synergistic effects of PD‐1/PD‐L1 blockade and STING pathway activation, subsequently enhance anti‐tumor immunity and suppress tumor ...
Yizhen Wang +12 more
wiley +1 more source
Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway [PDF]
, 2016 BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory disorders.
Blacher, S. +5 more
core
Nature Communications, 2020 Proteolytical processing of the growth factor VEGFC through the concerted activity of CCBE1 and ADAMTS3 is required for lymphatic development to occur.
Guangxia Wang +10 more
semanticscholar +1 more source
Small Methods, EarlyView.This work introduces a multiplexed imaging platform that integrates nanoplasmonic sensing with fluorescence microscopy for concomitant monitoring of extraspheroid secretions and intraspheroid features over extended periods with spatiotemporal resolution.
Saeid Ansaryan +7 more
wiley +1 more source
Lymphangiogenesis in the heart
The FASEB Journal, 2009 Our goal was to follow the development of the lymphatic system in the developing heart using markers that identify the lymphatics in adult tissues. The transcription factor Prox‐1 identified a branching network of vessels in the avian embryonic heart that first appeared on the outflow tract at Embryonic Day 5 (Hamburger and Hamilton Stage 25‐26).
Yong Qiu Doughman +8 more
openaire +2 more sources
Circulation Research, 2019 Rationale: Cardiac lymphangiogenesis contributes to the reparative process post-myocardial infarction, but the factors and mechanisms regulating it are not well understood.
Claire E. Trincot +8 more
semanticscholar +1 more source
Corneal Lymphatics: Role in Ocular Inflammation as Inducer and Responder of Adaptive Immunity [PDF]
, 2015 The normal cornea is devoid of lymphatic and blood vessels, thus suppressing both the afferent (lymphatic) and efferent (vascular) arms of the immune response–contributing to its ‘immune privilege’. Inflammation, however, negates this unique ‘immune’ and
Chauhan, Sunil K. +2 more
core +1 more source
Nectin4‐targeted molecular imaging in solid tumors: Current status and future perspectives
VIEW, EarlyView.In this review, we provide a concise overview of the mechanisms by which Nectin4 contributes to the pathogenesis of various malignancies and detail the classes of Nectin4‐targeted molecular probes. We then delve into the significant advancements in Nectin4‐targeted molecular imaging techniques, encompassing both nuclear medicine and optical imaging ...
Yongshun Liu +6 more
wiley +1 more source
Computational and Mathematical Methods in Medicine, 2003 While much effort is given to the modelling of tumour angiogenesis, little attention is paid to lymphangiogenesis and its potential role in tumour progression and metastasis. This is due at least in part to the controversy that surrounds tumour lymphangiogenesis—opinion is divided as to whether tumours actively promote the development of lymph channels
Catherine R. Tait, Pamela F. Jones
openaire +1 more source
Granulomatous inflammation in tuberculosis and sarcoidosis: does the lymphatic system contribute to disease? [PDF]
, 2019 A striking and unexplained feature of granulomatous inflammation is its anatomical association with the lymphatic system. Accumulating evidence suggests that lymphatic tracks and granulomas may alter the function of each other.
Gutierrez, Maximiliano G +2 more
core +1 more source