How Lymphatic Endothelial Cells Destabilize Regulatory T Cells. [PDF]
Arterioscler Thromb Vasc Biol, 2023 Lyu Q, Ley K.
europepmc +5 more sources
Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development [PDF]
eLife, 2017 The lymphatic system controls fluid homeostasis and the clearance of macromolecules from interstitial compartments. In mammals brain lymphatics were only recently discovered, with significant implications for physiology and disease. We examined zebrafish
Max van Lessen +5 more
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Single-nuclei multiomic analyses identify human cardiac lymphatic endothelial cells associated with coronary arteries in the epicardium [PDF]
Cell Reports, 2023 Summary: Cardiac lymphatic vessels play important roles in fluid homeostasis, inflammation, disease, and regeneration of the heart. The developing cardiac lymphatics in human fetal hearts are closely associated with coronary arteries, similar to those in
Stanislao Igor Travisano +5 more
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Digging deeper into lymphatic vessel formation
BMC Cell Biology, 2011 Background Abnormal lymphatic vessel formation (lymphangiogenesis) is associated with different pathologies such as cancer, lymphedema, psoriasis and graft rejection.
Thiry Marc +9 more
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PLoS Pathogens, 2010 Kaposi's sarcoma (KS) is the most common cancer among HIV-positive patients. Histogenetic origin of KS has long been elusive due to a mixed expression of both blood and lymphatic endothelial markers in KS tumor cells.
Jaehyuk Yoo +11 more
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Macroautophagy in lymphatic endothelial cells inhibits T cell–mediated autoimmunity [PDF]
Journal of Experimental Medicine, 2021 Lymphatic endothelial cells (LECs) present peripheral tissue antigens to induce T cell tolerance. In addition, LECs are the main source of sphingosine-1-phosphate (S1P), promoting naive T cell survival and effector T cell exit from lymph nodes (LNs). Autophagy is a physiological process essential for cellular homeostasis.
Guillaume Harlé +10 more
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A short review on lymphatic endothelial cell heterogeneity [PDF]
Inflammation and Regeneration, 2021 AbstractRecent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in distinct locations in the body. These studies have also revealed a conserved pattern of gene expression in LECs across animal species, as
Masayuki Miyasaka
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Lymphangioleiomyoma Cells and Lymphatic Endothelial Cells [PDF]
The American Journal of Pathology, 2010 Kuniaki Seyama +7 more
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Trimethylamine-N-oxide damages astrocytes and lymphatic endothelial cells in the cerebral lymphatic system. [PDF]
IBRO Neurosci RepSu ML +8 more
europepmc +3 more sources
Cells with Many Talents: Lymphatic Endothelial Cells in the Brain Meninges
Cells, 2021 The lymphatic system serves key functions in maintaining fluid homeostasis, the uptake of dietary fats in the small intestine, and the trafficking of immune cells. Almost all vascularized peripheral tissues and organs contain lymphatic vessels. The brain
Irina Suárez, Stefan Schulte-Merker
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