Results 21 to 30 of about 111,283 (329)

TGF-β signaling in lymphatic vascular vessel formation and maintenance

Frontiers in Physiology, 2022
Transforming growth factor (TGF)-β and its family members, including bone morphogenetic proteins (BMPs), nodal proteins, and activins, are implicated in the development and maintenance of various organs. Here, we review its role in the lymphatic vascular
Fumiko Itoh, Tetsuro Watabe
doaj   +1 more source

Extracellular matrix stiffness regulates the proliferation and migration capacities of lymphatic endothelial cells via FAT1. [PDF]

Front Cell Dev Biol
Xu Z, Yu J, Chen D, Liu Y, Zhang G, Guo Q, Yang C, Gao F, He Y, Du Y.   +9 more
europepmc   +3 more sources

Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment. [PDF]

PLoS ONE, 2014
Peripheral self-tolerance eliminates lymphocytes specific for tissue-specific antigens not encountered in the thymus. Recently, we demonstrated that lymphatic endothelial cells in mice directly express peripheral tissue antigens, including tyrosinase ...
Jarish N Cohen, Eric F Tewalt, Sherin J Rouhani, Erica L Buonomo, Amber N Bruce, Xiaojiang Xu, Stefan Bekiranov, Yang-Xin Fu, Victor H Engelhard   +8 more
doaj   +1 more source

Fine filaments in lymphatic endothelial cells [PDF]

The Journal of Cell Biology, 1976
Several and various types of cells contain fine cytoplasmic filaments closely resembling the myofilaments of muscle cells (2, 18, 23, 24). In many of these cells and especially when cultured, it has been demonstrated that some of these filaments react with heavy meromyosin (HMM) in the same way as do the actin filaments of muscle cells (3, 6 7).
J M, Lauweryns, J, Baert, W, De Loecker
openaire   +2 more sources

Lymphatic Endothelial-to-Myofibroblast Transition: A Potential New Mechanism Underlying Skin Fibrosis in Systemic Sclerosis

Cells, 2023
At present, only a few reports have addressed the possible contribution of the lymphatic vascular system to the pathogenesis of systemic sclerosis (SSc).
Irene Rosa, Eloisa Romano, Bianca Saveria Fioretto, Khadija El Aoufy, Silvia Bellando-Randone, Marco Matucci-Cerinic, Mirko Manetti   +6 more
doaj   +1 more source

Molecular characterization of lymphatic endothelial cells [PDF]

Proceedings of the National Academy of Sciences, 2002
The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial fluid and proteins and is an important entry point for leukocytes and tumor cells. Specialized functions of lymphatics suggest differences in the molecular composition of the lymphatic and blood vascular endothelium.
Simona Podgrabinska, Pascal Braun, Paula Velasco, Bryan Kloos, Michael S. Pepper, David G. Jackson, Mihaela Skobe   +6 more
openaire   +2 more sources

Regulation of VEGFR3 signaling in lymphatic endothelial cells. [PDF]

Front Cell Dev Biol
The receptor tyrosine kinase vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3) is the principal transmembrane receptor responsible for sensing and coordinating cellular responses to environmental lymphangiogenic stimuli in lymphatic endothelial cells (LECs).
Kuonqui KG, Campbell AC, Pollack BL, Shin J, Sarker A, Brown S, Park HJ, Mehrara BJ, Kataru RP.   +8 more
europepmc   +4 more sources

Cell Fate Determination of Lymphatic Endothelial Cells [PDF]

International Journal of Molecular Sciences, 2020
The lymphatic vasculature, along with the blood vasculature, is a vascular system in our body that plays important functions in fluid homeostasis, dietary fat uptake, and immune responses. Defects in the lymphatic system are associated with various diseases such as lymphedema, atherosclerosis, fibrosis, obesity, and inflammation.
openaire   +2 more sources

Sostdc1 Secreted from Cutaneous Lymphatic Vessels Acts as a Paracrine Factor for Hair Follicle Growth

Current Issues in Molecular Biology, 2022
In our previous study, we found that lymphatic vessels stimulate hair follicle growth through paracrine effects on dermal papilla cells. However, the paracrine factors secreted from cutaneous lymphatic vessels that can activate dermal papilla cells are ...
Sun-Young Yoon, Michael Detmar
doaj   +1 more source

Hypoxia Increases Breast Cancer Cell-Induced Lymphatic Endothelial Cell Migration

Neoplasia, 2008
Because tumors are characterized by hypoxic environments, we used a novel in vitro noninvasive magnetic resonance imaging assay to examine the influence of invasive MDA-MB-231 breast cancer cells on the invasion and migration of human dermal lymphatic microvascular endothelial cells (HMVEC-dLy) under normoxic and hypoxic conditions.
Maria Mikhaylova, Noriko Mori, Flonné Wildes, Piotr Walczak, Barjor Gimi, Zaver M. Bhujwalla   +5 more
openalex   +4 more sources