Results 31 to 40 of about 105,489 (333)
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation [PDF]
, 2018 Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Alve, S +17 more
core +1 more source
Stem Cell Reports, 2019 Summary: Exogenous cues involved in the regulation of the initial steps of lymphatic endothelial development remain largely unknown. We have used an in vitro model based on the co-culture of vascular precursors derived from mouse embryonic stem cell (ESC)
Mariela Subileau +6 more
doaj +1 more source
An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo. [PDF]
PLoS ONE, 2013 Afadin is an intracellular binding partner of nectins, cell-cell adhesion molecules, and plays important roles in the formation of cell-cell junctions. Afadin-knockout mice show early embryonic lethality, therefore little is known about the function of ...
Takashi Majima +8 more
doaj +1 more source
Lymphatic Endothelial Cell Plasticity in Development and Disease [PDF]
Physiology, 2017 The lymphatic vasculature is crucial for maintaining tissue-fluid homeostasis, providing immune surveillance and mediating lipid absorption. The lymphatic vasculature is tightly associated with the blood vasculature, although it exhibits distinct morphological and functional features.
Wanshu Ma, Guillermo Oliver
openaire +3 more sources
Neoplasia: An International Journal for Oncology Research, 2010 The lymphatic system plays a critical role in melanoma metastasis, and yet, virtually no information exists regarding the cellular and molecular mechanisms that take place between melanoma cells and the lymphatic vasculature.
Robert B. Rebhun +5 more
doaj +1 more source
Homeobox genes in normal and abnormal vasculogenesis [PDF]
, 2008 Homeobox containing genes are a family of transcription factors regulating normal development and controlling primary cellular processes (cell identity, cell division and differentiation) recently enriched by the discovery of their interaction with ...
Cantile M +3 more
core +1 more source
A short review on lymphatic endothelial cell heterogeneity
Inflammation and Regeneration, 2021 AbstractRecent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in distinct locations in the body. These studies have also revealed a conserved pattern of gene expression in LECs across animal species, as
openaire +4 more sources
Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis. [PDF]
, 2018 Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent for Kaposi's sarcoma (KS), which is one of the most common HIV-associated neoplasms.
Fan Li +9 more
core +3 more sources
Lymphatic Endothelial Cell Progenitors in the Tumor Microenvironment [PDF]
, 2020 Tumor lymphatics play a key role in cancer progression as they are solely responsible for transporting malignant cells to regional lymph nodes (LNs), a process that precedes and promotes systemic lethal spread. It is broadly accepted that tumor lymphatic sprouting is induced mainly by soluble factors derived from tumor-associated macrophages (TAMs) and
Sophia Ran, Lisa Volk-Draper
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Macroautophagy in lymphatic endothelial cells inhibits T cell–mediated autoimmunity
Journal of Experimental Medicine, 2021 Lymphatic endothelial cells (LECs) present peripheral tissue antigens to induce T cell tolerance. In addition, LECs are the main source of sphingosine-1-phosphate (S1P), promoting naive T cell survival and effector T cell exit from lymph nodes (LNs). Autophagy is a physiological process essential for cellular homeostasis.
Harlé, Guillaume +10 more
openaire +6 more sources