Results 41 to 50 of about 105,489 (333)

Single-nuclei multiomic analyses identify human cardiac lymphatic endothelial cells associated with coronary arteries in the epicardium

Cell Reports, 2023
Summary: Cardiac lymphatic vessels play important roles in fluid homeostasis, inflammation, disease, and regeneration of the heart. The developing cardiac lymphatics in human fetal hearts are closely associated with coronary arteries, similar to those in
Stanislao Igor Travisano, Michael R.M. Harrison, Matthew E. Thornton, Brendan H. Grubbs, Thomas Quertermous, Ching-Ling Lien   +5 more
doaj   +1 more source

Lymphatic Endothelial Differentiation in Pulmonary Lymphangioleiomyomatosis Cells [PDF]

Journal of Histochemistry & Cytochemistry, 2013
Pulmonary lymphangioleiomyomatosis (LAM) is a rare, low-grade neoplasm affecting almost exclusively women of childbearing age. LAM belongs to the family of perivascular epithelioid cell tumors, characterized by spindle and epithelioid cells with smooth muscle and melanocytic differentiation.
Lucia Schuger, Aliya N. Husain, Elizabeth Hyjek, Le Shen, Jennifer Jones, Jennifer M. Davis   +5 more
openaire   +3 more sources

T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions. [PDF]

, 2017
T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo ...
Coles, Marc, Debes, Gudrun F., Detmar, Michael, Frei, Thomas, Halin, Cornelia, Hunter, Morgan C., Melero, Ignacio, Proulx, Steven T, Rouzaut, Ana, Russo, Erica, Teijeira, Alvaro   +10 more
core   +3 more sources

Digging deeper into lymphatic vessel formation in vitro and in vivo

BMC Cell Biology, 2011
Background Abnormal lymphatic vessel formation (lymphangiogenesis) is associated with different pathologies such as cancer, lymphedema, psoriasis and graft rejection.
Thiry Marc, Foidart Jean-Michel, Lenoir Bénédicte, Maillard Catherine, Lamaye Françoise, Paupert Jenny, Erpicum Charlotte, Bruyère Françoise, Detry Benoit, Noël Agnès   +9 more
doaj   +1 more source

FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake

Molecular Medicine, 2020
Background Therapeutic lymphangiogenesis in an orthotopic lung transplant model has been shown to improve acute allograft rejection that is mediated at least in part through hyaluronan drainage.
Shikshya Shrestha, Woohyun Cho, Benjamin Stump, Jewel Imani, Anthony M. Lamattina, Pierce H. Louis, James Pazzanese, Ivan O. Rosas, Gary Visner, Mark A. Perrella, Souheil El-Chemaly   +10 more
doaj   +1 more source

A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis

Molecular Cancer, 2010
Background Lymph node metastasis constitutes a key event in tumor progression. The molecular control of this process is poorly understood. Heparan sulfate is a linear polysaccharide consisting of unique sulfate-modified disaccharide repeats that allow ...
Srinivasan R Sathish, Johns Scott C, Lawrence Roger, Truty Jadwiga, Yin Xin, Handel Tracy M, Fuster Mark M   +6 more
doaj   +1 more source

Claudin-3 inhibits tumor-induced lymphangiogenesis via regulating the PI3K signaling pathway in lymphatic endothelial cells

Scientific Reports, 2022
Claudin-3 is a tight junction protein that has often been associated with the progression and metastasis of various tumors. Here, the role of claudin-3 in tumor-induced lymphangiogenesis is investigated.
Ningjing Lei, Yanru Cheng, Jiajia Wan, Rosel Blasig, Anqi Li, Yueyue Bai, Reiner F. Haseloff, Ingolf E. Blasig, Linyu Zhu, Zhihai Qin   +9 more
doaj   +1 more source

Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors [PDF]

, 2005
The study of lymphatic vessels and lymphatic tumors has been hampered with difficulty due to the overlapping morphological features between blood and lymphatic endothelial cells, as well as to the lack of specific lymphatic endothelial markers.
Adhemar Longatto Filho, Alitalo, Belecky-Adams, Boshoff, Breiteneder-Geleff, Carmeliet, Carreira, Fletcher, Folpe, Jackson, Jorge S. Reis-Filho, José M. Lopes, Kahn, Lohela, Makinen, Oliver, Oliver, Oliver, Padera, Papoutsi, Papper, Partanen, Paula Silva, Petrova, Rafii, Reis-Filho, Rodriguez-Niedenfuhr, Rui M. Reis, Sauter, Stanislav Tomarev, Tomarev, Weiss, Wigle, Wigle, Wilting, Witmer, Xu   +36 more
core   +1 more source

PIK3CA mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations

PLOS ONE, 2018
Lymphatic malformations (LM) are characterized by the overgrowth of lymphatic vessels during pre- and postnatal development. Macrocystic, microcystic and combined forms of LM are known. The cysts are lined by lymphatic endothelial cells (LECs). Resection and sclerotherapy are the most common treatment methods.
Hannah Blesinger, Silke Kaulfuß, Thiha Aung, Sonja Schwoch, Lukas Prantl, Jochen Rößler, Jörg Wilting, Jürgen Becker   +7 more
openaire   +8 more sources

Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling [PDF]

, 2016
Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances the retraction of cancer-associated fibroblasts (CAFs) and therefore, 12(S)-HETE may enforce ...
Bago-Horvath, Zsuzsanna, Brendel, Konstantin Alexander, Brenner, Stefan, De Wever, Olivier, Dolznig, Helmut, Eichsteininger, Julia, Giessrigl, Benedikt, Holzner, Silvio, Huttary, Nicole, Jäger, Walter, Koperek, Oskar, Krenn, Liselotte, Krieger, Sigurd, Krupitza, Georg, Mader, Robert M, Marian, Brigitte, Milovanovic, Daniela, Nguyen, Chi Huu, Schachner, Helga, Schmidt, Wolfgang M, Senfter, Daniel, Stadler, Mira, Stadler, Serena   +22 more
core   +1 more source