Results 1 to 10 of about 679,897 (383)

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer [PDF]

Cell Death and Disease, 2023
Lymphatic metastasis is the most common pattern of bladder cancer (BCa) metastasis and has an extremely poor prognosis. Emerging evidence shows that ubiquitination plays crucial roles in various processes of tumors, including tumorigenesis and ...
Kanghua Xiao, Shengmeng Peng, Junlin Lu, Ting Zhou, Xuwei Hong, Siting Chen, Guangyao Liu, Hong Li, Jian Huang, Xu Chen, Tianxin Lin   +10 more
doaj   +3 more sources

BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids [PDF]

Cell Death and Disease, 2023
Esophageal squamous cell carcinoma (ESCC) is one of the fatal malignancies worldwide. It has an increased propensity to metastasize via lymphogenous routes in an early stage.
Xiufeng Xie, Lusong Tian, Yan Zhao, Fang Liu, Shuyang Dai, Xinglu Gu, Yuxin Ye, Lanping Zhou, Xinmiao Liu, Yulin Sun, Xiaohang Zhao   +10 more
doaj   +3 more sources

HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐dependent transcriptional program

Cancer Communications, 2022
Background Lymphatic metastasis has been associated with poor prognosis in bladder cancer patients with limited therapeutic options. Emerging evidence shows that heat shock factor 1 (HSF1) drives diversified transcriptome to promote tumor growth and ...
Ming Huang, Wen Dong, Ruihui Xie, Jilin Wu, Qiao Su, Wuguo Li, Kai Yao, Yuelong Chen, Qianghua Zhou, Qiang Zhang, Wenwen Li, Liang Cheng, Shengmeng Peng, Siting Chen, Jian Huang, Xu Chen, Tianxin Lin   +16 more
doaj   +2 more sources

ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer. [PDF]

Adv Sci (Weinh), 2023
As a key step of tumor lymphatic metastasis, lymphangiogenesis is regulated by VEGFC‐VEGFR3 signaling pathway mediated by immune cells, mainly macrophages, in the tumor microenvironment.
Zhang Q, Liu S, Wang H, Xiao K, Lu J, Chen S, Huang M, Xie R, Lin T, Chen X.   +9 more
europepmc   +3 more sources

Bacterial Lymphatic Metastasis in Infection and Immunity [PDF]

Cells, 2021
Lymphatic vessels permeate tissues around the body, returning fluid from interstitial spaces back to the blood after passage through the lymph nodes, which are important sites for adaptive responses to all types of pathogens. Involvement of the lymphatics in the pathogenesis of bacterial infections is not well studied.
Matthew K. Siggins, Shiranee Sriskandan
openaire   +6 more sources

Long Non-Coding RNA MAPK8IP1P2 Inhibits Lymphatic Metastasis of Thyroid Cancer by Activating Hippo Signaling via Sponging miR-146b-3p

Frontiers in Oncology, 2021
The principal issue derived from thyroid cancer is its high propensity to metastasize to the lymph node. Aberrant exprssion of long non-coding RNAs have been extensively reported to be significantly correlated with lymphatic metastasis of thyroid cancer.
Xiaoli Liu, Qingfeng Fu, Xuehai Bian, Yantao Fu, Jingwei Xin, Nan Liang, Shijie Li, Yishen Zhao, Li Fang, Changlin Li, Jiao Zhang, Gianlorenzo Dionigi, Hui Sun   +12 more
doaj   +2 more sources

Seven Genes Associated With Lymphatic Metastasis in Thyroid Cancer That Is Linked to Tumor Immune Cell Infiltration

Frontiers in Oncology, 2022
ObjectiveSince there are few studies exploring genes associated with lymphatic metastasis of thyroid carcinoma (THCA), this study was conducted to explore genes associated with lymphatic metastasis of THCA and to investigate the relationship with immune ...
Linfeng Wu, Yuying Zhou, Yaoyao Guan, Rongyao Xiao, Jiaohao Cai, Weike Chen, Mengmeng Zheng, Kaiting Sun, Chao Chen, Guanli Huang, Xiaogang Zhang, Xiaogang Zhang, Ziliang Qian, Ziliang Qian, Shurong Shen   +14 more
doaj   +2 more sources

Progression of Metastasis through Lymphatic System [PDF]

Cells, 2021
Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease status provides great prognostic power, but how lymph node metastases should be treated is under debate. Thus, it is important to understand the mechanisms by which lymph node metastases progress and how they can be targeted to provide therapeutic benefits.
Hengbo Zhou, Pin-ji Lei, Timothy P. Padera   +2 more
openaire   +4 more sources

A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis [PDF]

Molecular Cancer, 2010
Background Lymph node metastasis constitutes a key event in tumor progression. The molecular control of this process is poorly understood. Heparan sulfate is a linear polysaccharide consisting of unique sulfate-modified disaccharide repeats that allow ...
Srinivasan R Sathish, Johns Scott C, Lawrence Roger, Truty Jadwiga, Yin Xin, Handel Tracy M, Fuster Mark M   +6 more
doaj   +5 more sources

RAF1 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating LAGE1: an experimental research

Journal of Translational Medicine, 2022
Background Lymphatic metastasis was an independent prognostic risk factor for hypopharyngeal carcinoma and was the main cause of treatment failure. The purpose of this study was to screen the differential genes and investigate the mechanism of lymphatic ...
Yanshi Li, Min Pan, Tao Lu, Dan Yu, Chuan Liu, Zhihai Wang, Guohua Hu   +6 more
doaj   +2 more sources