PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor [PDF]
Cell Death and Disease, 2021 Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in southern China and Asia, and lymph node metastasis is an important cause for treatment failure.
Chuanghua Luo +13 more
doaj +3 more sources
Cellular components of tumor microenvironment: understanding their role in lymphatic metastasis of tumors [PDF]
Frontiers in PharmacologyMetastasis is the leading cause of cancer-related death in cancer patients. Tumor cells primarily spread through the hematogenous and lymphatic system.
Ziyi Wang +6 more
doaj +2 more sources
Lymphatic Expression of CLEVER-1 in Breast Cancer and Its Relationship with Lymph Node Metastasis [PDF]
, 2011 BACKGROUND Mechanisms regulating breast cancer lymph node metastasis are unclear. Staining of CLEVER-1 (common lymphatic endothelial and vascular endothelial receptor-1) in human breast tumors was used, along with in vitro techniques, to assess ...
Aula Ammar +6 more
openalex +6 more sources
Altered tumor microenvironment heterogeneity of penile cancer during progression from non‐lymphatic to lymphatic metastasis [PDF]
Cancer MedicineBackground Lymphatic metastasis is the major challenge in the treatment of penile cancer. The prognosis of individuals with lymphatic metastasis is extremely poor.
Da‐Ming Xu +6 more
doaj +2 more sources
Cancer Metastasis Through the Lymphatics: Invasion and Dissemination
LymphaticsCancer metastasis often accounts for the primary cause of cancer-related mortality, with the lymphatic system playing a pivotal role in the dissemination of malignant cells.
Chien-An A. Hu +2 more
doaj +2 more sources
LNMAC Promotes Cervical Squamous Cell Carcinoma Lymphatic Metastasis via Epigenetic Regulation of FGF2‐Induced Lymphangiogenesis [PDF]
Advanced ScienceThe lymph node is the most common site of distant metastasis of cervical squamous cell carcinoma (CSCC), which elicits dismal prognosis and limited efficiency for treatment. Elucidation of the mechanisms underlying CSCC lymphatic metastasis would provide
Chunyu Zhang +13 more
doaj +2 more sources
CXCR4/CXCL12 axis promotes lymphatic metastasis in tongue squamous cell carcinoma via PI3K/AKT signaling pathway [PDF]
Journal of Translational MedicineBackground Given that lymphatic metastasis represents a pivotal determinant of poor clinical outcomes in tongue squamous cell carcinoma (TSCC), this study aimed to elucidate the role of the CXCR4/CXCL12 chemokine axis in TSCC lymphatic metastasis and its
Huiquan Lou +6 more
doaj +2 more sources
An acidic microenvironment promotes lymphatic metastasis of melanoma by Thy-1 in endothelial cells and integrin αvβ3 in tumor cells [PDF]
Discover OncologyMelanoma tissues exhibit an acidic microenvironment compared with that of surrounding normal tissues. However, the effects of acidic conditions on the lymphatic metastasis, a crucial prognostic factor for patients with melanoma, are unclear.
Akiya Ibe +4 more
doaj +2 more sources
PKM2 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating epithelial-mesenchymal transition: an experimental research [PDF]
Diagnostic PathologyBackground Patients with hypopharyngeal carcinoma (HPC) have a poor prognosis mainly because of lymphatic metastasis. This research aimed to determine the PKM2 role in lymphatic metastasis in HPC and the underlying molecular mechanism contributing to ...
Xin Zhou +7 more
doaj +2 more sources
Chitinase 3‐like 1 expression associated with lymphatic metastasis and prognosis in urothelial carcinoma of the bladder [PDF]
Clinical & Translational ImmunologyObjectives Lymphatic metastasis, an early stage of the metastasis process, is associated with adverse clinical outcomes in urothelial carcinoma of the bladder (UCB).
Bo Wang +12 more
doaj +2 more sources