Results 1 to 10 of about 92,817 (240)

Cellular components of tumor microenvironment: understanding their role in lymphatic metastasis of tumors [PDF]

Frontiers in Pharmacology
Metastasis is the leading cause of cancer-related death in cancer patients. Tumor cells primarily spread through the hematogenous and lymphatic system.
Ziyi Wang, Ziyi Wang, Ziyi Wang, Zehui Li, Xiangyu Sun, Wanfu Men, Yan Xu   +6 more
doaj   +2 more sources

Altered tumor microenvironment heterogeneity of penile cancer during progression from non‐lymphatic to lymphatic metastasis [PDF]

Cancer Medicine
Background Lymphatic metastasis is the major challenge in the treatment of penile cancer. The prognosis of individuals with lymphatic metastasis is extremely poor.
Da‐Ming Xu, Xiao‐Yu Zhuang, Hua‐Li Ma, Zai‐Shang Li, Li‐Chao Wei, Jun‐Hang Luo, Hui Han   +6 more
doaj   +2 more sources

CD169+ Macrophage‐Targeted Immunomodulator to Restore Phagocytic Function and Enhance Antigen Presentation for Lymphatic Metastasis Eradication [PDF]

Advanced Science
Lymphatic metastasis is a major cause of tumor treatment failure, with the immunosuppressive status of lymphatic macrophages significantly impairing antitumor immunity.
Xiayun Chen, Lichong Lu, Yibin Liu, Ziqi Liang, Jianqiao Li, Zhouchuan Shao, Youzhi Tang, Jianhua Zou, Shiying Li, Xiaoyuan Chen   +9 more
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LNMAC Promotes Cervical Squamous Cell Carcinoma Lymphatic Metastasis via Epigenetic Regulation of FGF2‐Induced Lymphangiogenesis [PDF]

Advanced Science
The lymph node is the most common site of distant metastasis of cervical squamous cell carcinoma (CSCC), which elicits dismal prognosis and limited efficiency for treatment. Elucidation of the mechanisms underlying CSCC lymphatic metastasis would provide
Chunyu Zhang, Li Yuan, Weijia Wen, Caixia Shao, Yuandong Liao, Yan Jia, Xueyuan Zhao, Yan Liao, Dingze Xu, Linna Chen, Guofen Yang, Hongye Jiang, Wei Wang, Shuzhong Yao   +13 more
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CXCR4/CXCL12 axis promotes lymphatic metastasis in tongue squamous cell carcinoma via PI3K/AKT signaling pathway [PDF]

Journal of Translational Medicine
Background Given that lymphatic metastasis represents a pivotal determinant of poor clinical outcomes in tongue squamous cell carcinoma (TSCC), this study aimed to elucidate the role of the CXCR4/CXCL12 chemokine axis in TSCC lymphatic metastasis and its
Huiquan Lou, Yichao Xia, Shengjie Shao, Xiang Liu, Zengzheng Li, Hongbin Yu, Yongsheng Li   +6 more
doaj   +2 more sources

An acidic microenvironment promotes lymphatic metastasis of melanoma by Thy-1 in endothelial cells and integrin αvβ3 in tumor cells [PDF]

Discover Oncology
Melanoma tissues exhibit an acidic microenvironment compared with that of surrounding normal tissues. However, the effects of acidic conditions on the lymphatic metastasis, a crucial prognostic factor for patients with melanoma, are unclear.
Akiya Ibe, Masako Nakanishi, Kurumi Higashimoto, Yasuteru Muragaki, Shogo Ehata   +4 more
doaj   +2 more sources

Chitinase 3‐like 1 expression associated with lymphatic metastasis and prognosis in urothelial carcinoma of the bladder [PDF]

Clinical & Translational Immunology
Objectives Lymphatic metastasis, an early stage of the metastasis process, is associated with adverse clinical outcomes in urothelial carcinoma of the bladder (UCB).
Bo Wang, Ke Chen, Mingchao Gao, Xi Sun, Wang He, Junyu Chen, Wenjuan Yang, Tenghao Yang, Haide Qin, Honglian Ruan, Hao Huang, Tianxin Lin, Jian Huang   +12 more
doaj   +2 more sources

Long Non-Coding RNA MAPK8IP1P2 Inhibits Lymphatic Metastasis of Thyroid Cancer by Activating Hippo Signaling via Sponging miR-146b-3p

Frontiers in Oncology, 2021
The principal issue derived from thyroid cancer is its high propensity to metastasize to the lymph node. Aberrant exprssion of long non-coding RNAs have been extensively reported to be significantly correlated with lymphatic metastasis of thyroid cancer.
Xiaoli Liu, Qingfeng Fu, Xuehai Bian, Yantao Fu, Jingwei Xin, Nan Liang, Shijie Li, Yishen Zhao, Li Fang, Changlin Li, Jiao Zhang, Gianlorenzo Dionigi, Hui Sun   +12 more
doaj   +1 more source

Progression of Metastasis through Lymphatic System [PDF]

Cells, 2021
Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease status provides great prognostic power, but how lymph node metastases should be treated is under debate. Thus, it is important to understand the mechanisms by which lymph node metastases progress and how they can be targeted to provide therapeutic benefits.
Hengbo Zhou, Pin-ji Lei, Timothy P. Padera   +2 more
openaire   +3 more sources

Patterns of lymph node metastasis in level IIB and contralateral level VI for papillary thyroid carcinoma with pN1b and safety of low collar extended incision for neck dissection in level II

World Journal of Surgical Oncology, 2023
Objective To explore relevant clinical factors of level IIB and contralateral level VI lymph node metastasis and evaluate the safety of low-collar extended incision (LCEI) for lymph node dissection in level II for papillary thyroid carcinoma (PTC) with ...
Yudong Ning, Yuebai Liu, Dingfen Zeng, Yuqiu Zhou, Linjie Ma, Shuang Dong, Jianfeng Sheng, Gaosong Wu, Wen Tian, Yongcong Cai, Chao Li   +10 more
doaj   +1 more source