Results 11 to 20 of about 575,621 (304)

PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor

Cell Death and Disease, 2021
Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in southern China and Asia, and lymph node metastasis is an important cause for treatment failure.
Chuanghua Luo, Haofan Yin, Tianxiao Gao, Caiqi Ma, Junxi Liu, Ting Zhang, Zumin Xu, Xi Wang, Danrui Zhang, Weiwei Qi, Zhonghan Yang, Guoquan Gao, Xia Yang, Ti Zhou   +13 more
doaj   +2 more sources

Anlotinib suppresses lymphangiogenesis and lymphatic metastasis in lung adenocarcinoma through a process potentially involving VEGFR-3 signaling

Cancer Biology & Medicine, 2020
Objective: Lymphatic metastasis is one of the leading causes of malignancy dispersion in various types of cancer. However, few anti-lymphangiogenic drugs have been approved for clinical use to date. Therefore, new therapies to block lymphangiogenesis are
Tingting Qin, Zhujun Liu, Jing Wang, Junling Xia, Shaochuan Liu, Yanan Jia, Hailin Liu, Kai Li   +7 more
doaj   +2 more sources

Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer

Nature Communications, 2021
The mechanism of how VEGF-C is regulated to promote lymphatic metastasis of oesophageal cancer is unclear. Here the authors show that nicotine prevents the mRNA decay of VEGF-C mRNA and promotes lymphatic metastasis by downregulating deubiquitinase OTUD3
Meng Wang, Yue Li, Yunyun Xiao, Muwen Yang, Jinxin Chen, Yunting Jian, Xin Chen, Dongni Shi, Xiangfu Chen, Ying Ouyang, Lingzhi Kong, Xinjian Huang, Jiewen Bai, Chuyong Lin, Libing Song   +14 more
doaj   +2 more sources

Microfluidic System to Analyze the Effects of Interleukin 6 on Lymphatic Breast Cancer Metastasis

Frontiers in Bioengineering and Biotechnology, 2021
Metastasis is the primary cause of a large number of cancer-associated deaths. By portraying the precise environment of the metastasis process in vitro, the microfluidic system provides useful insights on the mechanisms underlying cancer cell migration ...
Hyeon-Yeol Cho, Hyeon-Yeol Cho, Jin-Ha Choi, Kyeong-Jun Kim, Minkyu Shin, Jeong-Woo Choi   +5 more
doaj   +2 more sources

Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1 [PDF]

Oncogene, 2018
Cancer-secreted exosomal miRNAs are emerging mediators of cancer-stromal cross-talk in the tumor environment. Our previous miRNAs array of cervical squamous cell carcinoma (CSCC) clinical specimens identified upregulation of miR-221-3p.
Chenfei Zhou, Jing Ma, Lei Huang, Hongyan Yi, Yanmei Zhang, Xiang‐Guang Wu, Rui-Ming Yan, Liang Li, Mei Zhong, Yanhong Yu, Sha Wu, Wei Wang   +11 more
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Mutated EPHA2 is a target for combating lymphatic metastasis in intrahepatic cholangiocarcinoma [PDF]

International Journal of Cancer, 2018
Exploring the genetic aberrations favoring metastasis is important for understanding and developing novel strategies to combat cancer metastasis. It remains lack of effective treatment for the dismal prognosis of intrahepatic cholangiocarcinoma (ICC ...
Yuan‐Yuan Sheng, Jinwang Wei, Yu Zhang, Xiaomei Gao, Zheng Wang, Jing Yang, Shican Yan, Ying Zhu, Ze Zhang, Da Xu, Chaoqun Wang, Yan Zheng, Qiongzhu Dong, Lun‐Xiu Qin   +13 more
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Gene signature characteristic of elevated stromal infiltration and activation is associated with increased risk of hematogenous and lymphatic metastasis in serous ovarian cancer [PDF]

BMC Cancer, 2019
The clinical significance of hematogenous and lymphatic metastasis in ovarian cancer has been increasingly addressed, as it plays an imperative role in the formation of both intraperitoneal and distant metastases.
Huiran Yue, Jieyu Wang, Ruifang Chen, Xiaoman Hou, Jun Li, Xin Lü   +5 more
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ETV4 Mediated Tumor‐Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer (Adv. Sci. 11/2023)

Advancement of science, 2023
As a key step of tumor lymphatic metastasis, lymphangiogenesis is regulated by VEGFC‐VEGFR3 signaling pathway mediated by immune cells, mainly macrophages, in the tumor microenvironment.
Qiang Zhang, Sen Liu, Hongjin Wang, Kang‐hua Xiao, Junlin Lu, Siting Chen, Ming Huang, Ruihui Xie, Tianxin Lin, Xu Chen   +9 more
semanticscholar   +2 more sources

CRIP1 Reshapes the Gastric Cancer Microenvironment to Facilitate Development of Lymphatic Metastasis

Advancement of science, 2023
Lymphangiogenesis in tumors provides an auxiliary route for cancer cell invasion to drainage lymph nodes, facilitating the development of lymphatic metastasis (LM).
Zhonghua Wu, Bicheng Qu, Minxian Yuan, J. Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhen-ning Wang   +9 more
semanticscholar   +1 more source

Mechanisms of lymphatic metastasis [PDF]

Journal of Clinical Investigation, 2014
Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby promoting LN metastasis. Surprising recent evidence suggests that lymphatic vessels do not merely represent passive channels for tumor spread, but that they may actively promote tumor ...
Karaman Sinem, Detmar Michael
openaire   +3 more sources