Results 21 to 30 of about 732,589 (264)

Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer

Nature Communications, 2021
The mechanism of how VEGF-C is regulated to promote lymphatic metastasis of oesophageal cancer is unclear. Here the authors show that nicotine prevents the mRNA decay of VEGF-C mRNA and promotes lymphatic metastasis by downregulating deubiquitinase OTUD3
Meng Wang, Yue Li, Yunyun Xiao, Muwen Yang, Jinxin Chen, Yunting Jian, Xin Chen, Dongni Shi, Xiangfu Chen, Ying Ouyang, Lingzhi Kong, Xinjian Huang, Jiewen Bai, Chuyong Lin, Libing Song   +14 more
doaj   +2 more sources

Loss of GATA6 expression promotes lymphatic metastasis in bladder cancer [PDF]

The FASEB Journal, 2020
Lymph node metastasis is associated with tumor relapse and poor patient prognosis in bladder cancer. However, the mechanisms by which bladder carcinoma cells induce lymphangiogenesis and further promote metastasis in the lymphatic system remain unclear ...
Chanjuan Wang, Qinghua Liu, Ming Huang, Qianghua Zhou, Xiaoyu Zhang, Jingtong Zhang, Ruihui Xie, Yanqi Yu, Shang Chen, Jian‐Bing Fan, Xu Chen   +10 more
openalex   +2 more sources

ETV4 Mediated Tumor‐Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer

Advancement of science, 2023
As a key step of tumor lymphatic metastasis, lymphangiogenesis is regulated by VEGFC‐VEGFR3 signaling pathway mediated by immune cells, mainly macrophages, in the tumor microenvironment.
Qiang Zhang, Sen Liu, Hongjin Wang, Kang‐hua Xiao, Junlin Lu, Siting Chen, Ming Huang, Ruihui Xie, Tianxin Lin, Xu Chen   +9 more
semanticscholar   +1 more source

Patterns of lymph node metastasis in level IIB and contralateral level VI for papillary thyroid carcinoma with pN1b and safety of low collar extended incision for neck dissection in level II

World Journal of Surgical Oncology, 2023
Objective To explore relevant clinical factors of level IIB and contralateral level VI lymph node metastasis and evaluate the safety of low-collar extended incision (LCEI) for lymph node dissection in level II for papillary thyroid carcinoma (PTC) with ...
Yudong Ning, Yuebai Liu, Dingfen Zeng, Yuqiu Zhou, Linjie Ma, Shuang Dong, Jianfeng Sheng, Gaosong Wu, Wen Tian, Yongcong Cai, Chao Li   +10 more
doaj   +1 more source

Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.

PLoS ONE, 2021
MACC1 gene is a newly discovered gene and plays an important role in the metastasis of colorectal cancer (CRC). The objective of this study was to investigate whether MACC1 is an independent factor associated with lymphatic metastasis in CRC patients. We
Zheying Zhang, Huijie Jia, Yuhang Wang, Baoshun Du, Jiateng Zhong   +4 more
doaj   +1 more source

Mechanisms of lymphatic metastasis [PDF]

Journal of Clinical Investigation, 2014
Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby promoting LN metastasis. Surprising recent evidence suggests that lymphatic vessels do not merely represent passive channels for tumor spread, but that they may actively promote tumor ...
Karaman Sinem, Detmar Michael
openaire   +2 more sources

Exosomal miR-10527-5p Inhibits Migration, Invasion, Lymphangiogenesis and Lymphatic Metastasis by Affecting Wnt/β-Catenin Signaling via Rab10 in Esophageal Squamous Cell Carcinoma

International Journal of Nanomedicine, 2023
Background Cancer cell-derived exosomal microRNAs (miRNAs) play critical role in orchestrating intercellular communication between tumor cells and tumor microenvironmental factors, including lymphatic endothelial cells (LECs). Nevertheless, the functions
Zhaohua Xiao, Xumei Feng, Yongjia Zhou, Peiwei Li, Junwen Luo, Wenhao Zhang, Jie Zhou, Jiangfeng Zhao, Dong Wang, Yongjie Wang, Zhongxian Tian, Xiaogang Zhao   +11 more
semanticscholar   +1 more source

Cancer-associated fibroblast-derived PAI-1 promotes lymphatic metastasis via the induction of EndoMT in lymphatic endothelial cells

Journal of experimental & clinical cancer research : CR, 2023
Background Endothelial-mesenchymal transition (EndoMT) is an emerging adaptive process that modulates lymphatic endothelial function to drive aberrant lymphatic vascularization in the tumour microenvironment (TME); however, the molecular determinants ...
Wenfei Wei, Hui-Ling Zhou, Pei Chen, Xiaodi Huang, Long Huang, Luojiao Liang, Chu-Hong Guo, Chenfei Zhou, Lan Yu, Liangsheng Fan, Wen Wang   +10 more
semanticscholar   +1 more source

CRIP1 Reshapes the Gastric Cancer Microenvironment to Facilitate Development of Lymphatic Metastasis

Advancement of science, 2023
Lymphangiogenesis in tumors provides an auxiliary route for cancer cell invasion to drainage lymph nodes, facilitating the development of lymphatic metastasis (LM).
Zhonghua Wu, Bicheng Qu, Minxian Yuan, J. Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhen-ning Wang   +9 more
semanticscholar   +1 more source

Advances in lymphatic metastasis of non-small cell lung cancer. [PDF]

Cell Commun Signal
Lung cancer is a deeply malignant tumor with high incidence and mortality. Despite the rapid development of diagnosis and treatment technology, abundant patients with lung cancer are still inevitably faced with recurrence and metastasis, contributing to ...
Zhang X, Ma L, Xue M, Sun Y, Wang Z.
europepmc   +2 more sources