Results 31 to 40 of about 709,350 (366)

The characteristics of isolated para-aortic lymph node metastases in endometrial cancer and their prognostic significance

Therapeutic Advances in Medical Oncology, 2020
Background: The aim of this study was to clarify the features and prognostic significance of isolated para-aortic lymphatic metastasis of endometrial cancer.
Jianbin Guo, Haili Qian, Fei Ma, Ying Zhang, Xiujuan Cui, Hua Duan   +5 more
doaj   +1 more source

RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner

Journal of experimental & clinical cancer research : CR, 2021
Lymph node metastasis is the main cause of poor prognosis of head and neck squamous carcinoma (HNSCC) patients. N6-methyladenosine (m6A) RNA modification is an emerging epigenetic regulatory mechanism for gene expression, and as a novel m6A reader ...
Dan Yu, Min Pan, Yanshi Li, T. Lu, Zhihai Wang, Chuan Liu, G. Hu   +6 more
semanticscholar   +1 more source

Paclitaxel treatment enhances lymphatic metastasis of B16F10 melanoma cells via CCL21/CCR7 axis

International Journal on Biological Sciences, 2022
Chemotherapeutic drugs have been successfully used to treat several cancers, including melanoma. However, metastasis occasionally occurs after chemotherapy.
Li Zhang, Linyu Zhu, Xiaohan Yao, Xiaohan Lou, Jiajia Wan, Xixi Duan, L. Pan, Anqi Li, Zhuoyu Gu, Ming Wang, Fazhan Wang, Zhihai Qin   +11 more
semanticscholar   +1 more source

TGF-β signaling in lymphatic vascular vessel formation and maintenance

Frontiers in Physiology, 2022
Transforming growth factor (TGF)-β and its family members, including bone morphogenetic proteins (BMPs), nodal proteins, and activins, are implicated in the development and maintenance of various organs. Here, we review its role in the lymphatic vascular
Fumiko Itoh, Tetsuro Watabe
doaj   +1 more source

Tumor‐derived exosomal BCYRN1 activates WNT5A/VEGF‐C/VEGFR3 feedforward loop to drive lymphatic metastasis of bladder cancer

Clinical and Translational Medicine, 2021
Background Patients with lymph node (LN) metastatic bladder cancer (BCa) present with extremely poor prognosis. BCa‐derived exosomes function as crucial bioactive cargo carriers to mediate the signal transduction in tumor microenvironment triggering ...
Hanhao Zheng, Changhao Chen, Yuming Luo, Min Yu, Wang He, M. An, Bowen Gao, Yao Kong, Yiyao Ya, Yan Lin, Yuting Li, K. Xie, Jian Huang, Tianxin Lin   +13 more
semanticscholar   +1 more source

Lymphatic System Metastasis [PDF]

British Journal of Cancer, 1981
For the physician who works at bedside or clinic with cancer patients, knowledge of lymphatic spread of tumors is based on the great anatomic work by Rouviere published in the early years of this century. In 1972, Haagensen's text on the lymphatics in cancer became the useful clinical counterpart of that approach, showing by surgical dissection and the
openaire   +4 more sources

IFN-γ–dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis

Science Advances, 2022
Tumor-associated lymphatic vessels promote metastasis and regulate antitumor immune responses. Here, we assessed the impact of cytotoxic T cells on the local lymphatic vasculature and concomitant tumor dissemination during an antitumor response ...
L. Garnier, R. Pick, J. Montorfani, Mengzhu Sun, D. Brighouse, Nicolas Liaudet, T. Kammertoens, T. Blankenstein, Nicolas Page, Jeremiah Bernier-Latamani, Ngoc Lan Tran, T. Petrova, D. Merkler, C. Scheiermann, S. Hugues   +14 more
semanticscholar   +1 more source

Endothelial-specific depletion of TGF-β signaling affects lymphatic function

Inflammation and Regeneration, 2021
Background Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis.
Kunpei Fukasawa, Kako Hanada, Kei Ichikawa, Masanori Hirashima, Takahiro Takagi, Susumu Itoh, Testuro Watabe, Fumiko Itoh   +7 more
doaj   +1 more source

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation [PDF]

, 2018
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Alve, S, Balistreri, G, Gramolelli, S, Hautaniemi, S, Icay, K, Ivaska, J, Lehti, K, Niiranen, O, Ojala, PM, Paatero, I, Pekkonen, P, Perälä, N, Repo, P, Saharinen, P, Taiwo, A, Tatti-Bugaeva, O, Tuohinto, K, Zinovkina, N   +17 more
core   +1 more source

Polysaccharides From Lentinus Edodes Inhibits Lymphangiogenesis via the Toll-Like Receptor 4/JNK Pathway of Cancer-Associated Fibroblasts

Frontiers in Oncology, 2021
Polysaccharides from Lentinus edodes (L. edodes) have been successfully used as adjuvant chemotherapy drug to treat lymphatic metastasis in some malignancies, such as colorectal cancer (CRC), lung cancer and gastric cancer.
Yuanyuan Wang, Yanqiong Zeng, Linyu Zhu, Jiajia Wan, Ningjing Lei, Xiaohan Yao, Xixi Duan, Yana Zhang, Yanru Cheng, Ning Tao, Zhihai Qin   +10 more
doaj   +1 more source