Results 31 to 40 of about 732,589 (264)

Long non-coding RNA MFSD4A-AS1 promotes lymphangiogenesis and lymphatic metastasis of papillary thyroid cancer

Endocrine-Related Cancer, 2023
Lymphatic metastasis is the leading cause responsible for recurrence and progression in papillary thyroid cancer (PTC), where dysregulation of long non-coding RNAs (lncRNAs) has been extensively demonstrated to be implicated.
Xiaoli Liu, Chunhai Zhang, Xiaomiao Wang, Can Cui, Hanwen Cui, Baishu Zhu, Anqi Chen, Lu Zhang, J. Xin, Q. Fu, G. Dionigi, Hui Sun   +11 more
semanticscholar   +1 more source

RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner

Journal of experimental & clinical cancer research : CR, 2021
Lymph node metastasis is the main cause of poor prognosis of head and neck squamous carcinoma (HNSCC) patients. N6-methyladenosine (m6A) RNA modification is an emerging epigenetic regulatory mechanism for gene expression, and as a novel m6A reader ...
Dan Yu, Min Pan, Yanshi Li, T. Lu, Zhihai Wang, Chuan Liu, G. Hu   +6 more
semanticscholar   +1 more source

Lymphatic System Metastasis [PDF]

British Journal of Cancer, 1981
For the physician who works at bedside or clinic with cancer patients, knowledge of lymphatic spread of tumors is based on the great anatomic work by Rouviere published in the early years of this century. In 1972, Haagensen's text on the lymphatics in cancer became the useful clinical counterpart of that approach, showing by surgical dissection and the
openaire   +2 more sources

The characteristics of isolated para-aortic lymph node metastases in endometrial cancer and their prognostic significance

Therapeutic Advances in Medical Oncology, 2020
Background: The aim of this study was to clarify the features and prognostic significance of isolated para-aortic lymphatic metastasis of endometrial cancer.
Jianbin Guo, Haili Qian, Fei Ma, Ying Zhang, Xiujuan Cui, Hua Duan   +5 more
doaj   +1 more source

Multifunctional Gold Nanoclusters for Effective Targeting, Near-Infrared Fluorescence Imaging, Diagnosis, and Treatment of Cancer Lymphatic Metastasis

ACS Nano, 2022
Developing effective lymph-node (LN) targeting and imaging probes is crucial for the early detection and diagnosis of tumor metastasis to improve patient survival. Most current clinical LN imaging probes are based on small organic dyes (e.g., indocyanine
Zeyang Pang, Weixiao Yan, Jie Yang, Qizhen Li, Yuan Guo, Dejian Zhou, Xingyu Jiang   +6 more
semanticscholar   +1 more source

Lymphatic metastasis due to glioblastoma [PDF]

Neurosciences, 2016
Glioblastomas are the most common malignant primary brain tumor. Only 0.2%-0.5% of cases metastasise outside the brain.[1][1],[2][2] We present a rare case of glioblastoma with bilateral cervical lymph node metastases.
Wassati, Husam, Loo, Suat W., Low, Hu L.
openaire   +2 more sources

TGF-β signaling in lymphatic vascular vessel formation and maintenance

Frontiers in Physiology, 2022
Transforming growth factor (TGF)-β and its family members, including bone morphogenetic proteins (BMPs), nodal proteins, and activins, are implicated in the development and maintenance of various organs. Here, we review its role in the lymphatic vascular
Fumiko Itoh, Tetsuro Watabe
doaj   +1 more source

Tumor‐derived exosomal BCYRN1 activates WNT5A/VEGF‐C/VEGFR3 feedforward loop to drive lymphatic metastasis of bladder cancer

Clinical and Translational Medicine, 2021
Background Patients with lymph node (LN) metastatic bladder cancer (BCa) present with extremely poor prognosis. BCa‐derived exosomes function as crucial bioactive cargo carriers to mediate the signal transduction in tumor microenvironment triggering ...
Hanhao Zheng, Changhao Chen, Yuming Luo, Min Yu, Wang He, M. An, Bowen Gao, Yao Kong, Yiyao Ya, Yan Lin, Yuting Li, K. Xie, Jian Huang, Tianxin Lin   +13 more
semanticscholar   +1 more source

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation [PDF]

, 2018
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Alve, S, Balistreri, G, Gramolelli, S, Hautaniemi, S, Icay, K, Ivaska, J, Lehti, K, Niiranen, O, Ojala, PM, Paatero, I, Pekkonen, P, Perälä, N, Repo, P, Saharinen, P, Taiwo, A, Tatti-Bugaeva, O, Tuohinto, K, Zinovkina, N   +17 more
core   +1 more source

Endothelial-specific depletion of TGF-β signaling affects lymphatic function

Inflammation and Regeneration, 2021
Background Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis.
Kunpei Fukasawa, Kako Hanada, Kei Ichikawa, Masanori Hirashima, Takahiro Takagi, Susumu Itoh, Testuro Watabe, Fumiko Itoh   +7 more
doaj   +1 more source