Results 81 to 90 of about 1,092,661 (368)

The Interplay Between Lymphatic Vessels and Chemokines

Frontiers in Immunology, 2019
Chemokines are a family of small protein cytokines that act as chemoattractants to migrating cells, in particular those of the immune system. They are categorized functionally as either homeostatic, constitutively produced by tissues for basal levels of ...
R. Farnsworth, T. Karnezis, Simon J Maciburko, Scott N. Mueller, S. Stacker   +4 more
semanticscholar   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Leukocyte Trafficking via Lymphatic Vessels in Atherosclerosis

Cells, 2021
In recent years, lymphatic vessels have received increasing attention and our understanding of their development and functional roles in health and diseases has greatly improved. It has become clear that lymphatic vessels are critically involved in acute
Kim Pin Yeo, Hwee Ying Lim, Veronique Angeli   +2 more
doaj   +1 more source

Development and plasticity of meningeal lymphatic vessels

Journal of Experimental Medicine, 2017
The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their possible involvement in neuropathological processes, yet little is known about their development or maintenance.
Salli Antila, Sinem Karaman, H. Nurmi, M. Airavaara, M. Voutilainen, T. Mathivet, D. Chilov, Zhilin Li, Tapani K. Koppinen, Jun-Hee Park, Shentong Fang, Aleksanteri Aspelund, M. Saarma, A. Eichmann, Jean-Léon Thomas, K. Alitalo   +15 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The role of lymphatics in renal inflammation [PDF]

, 2017
Progressive renal diseases are characterized by tubulointerstitial inflammatory cell recruitment, tubular atrophy and fibrosis. Various aspects of the recruitment of leukocytes have been extensively studied, but the exit routes (i.e.
Bonani, Marco, Seeger, Harald, Segerer, Stephan   +2 more
core  

Homeobox genes in normal and abnormal vasculogenesis [PDF]

, 2008
Homeobox containing genes are a family of transcription factors regulating normal development and controlling primary cellular processes (cell identity, cell division and differentiation) recently enriched by the discovery of their interaction with ...
Cantile M, CILLO, CLEMENTE, Schiavo G, Terracciano L   +3 more
core   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Impaired meningeal lymphatic drainage in Listeria monocytogenes infection

Frontiers in Immunology
Previous studies have demonstrated an association between lymphatic vessels and diseases caused by bacterial infections. Listeria monocytogenes (LM) bacterial infection can affect multiple organs, including the intestine, brain, liver and spleen, which ...
Jian Feng, Yuanzhen Ren, Xilin Wang, Xilin Wang, Xiaojing Li, Xingguo Zhu, Baokai Zhang, Baokai Zhang, Qi Zhao, Xiaochen Sun, Xinxin Tian, Hongyang Liu, Fan Dong, Xiu-Li Li, Linlin Qi, Bin Wei, Bin Wei   +16 more
doaj   +1 more source

Mouse Brain Lymphatic Vessels

ACS Chemical Neuroscience
Abstract The lymphatic system plays a vital role in immune function and waste removal, yet its involvement in the brain has remained largely unexplored. This study provides compelling evidence of lymphatic vessels in the mouse brain, specifically in the cortex, thalamus, and hippocampus.
Amin Tamadon, Alireza Afshar, Nadiar M. Mussin, Kulyash R. Zhilisbayeva, Madina A. Kurmanalina, Akmaral Baspakova, Raisa A. Aringazina, Mahdi Mahdipour, Nader Tanideh, Arezoo Khoradmehr, Mostafa Najarasl, Payam Taheri   +11 more
openaire   +1 more source