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Phase I Study of Fianlimab, a Human Lymphocyte Activation Gene-3 (LAG-3) Monoclonal Antibody, in Combination With Cemiplimab in Advanced Melanoma. [PDF]

open access: yesJ Clin Oncol
Hamid O   +31 more
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The Activation of Fetal Lymphocytes

Scandinavian Journal of Haematology, 1973
Fetal lymphocytes from the cord blood of normal full‐term fetuses can be stimulated in vitro by PHA to transformation and mitotic division. The reaction kinetics differ from those of adult cells, in that the minimum G1 period is about 4 h shorter. However, the cord blood also contains a small number of lymphocytes, which enter the S period very soon ...
T H, Weber, B, Santesson, V T, Skoog
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The Activation of T Lymphocytes

Rheumatic Disease Clinics of North America, 1987
The events involved in T cell activation are initiated at the cell surface by the interaction of ligands with specific cell surface receptors on the T cell. Central to antigen-induced activation is the CD3/Ti complex, a complex multi-chain receptor responsible for antigen/MHC recognition and signal transduction. Triggering the CD3/Ti complex results in
L K, Bockenstedt   +3 more
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Calcium and lymphocyte activation

Cellular Immunology, 1976
Abstract The role of ionized calcium in the early phases of activation of human peripheral blood lymphocytes was evaluated by stimulating the cells with a calcium ionophore A23187 (Lilly) or with mitogenic lections over a broad range of extracellular calcium concentrations ( 1000 μ M ).
W C, Greene, C M, Parker, C W, Parker
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Migration of Activated Lymphocytes

1993
When lymphocytes leave the primary lymphoid organs as mature but naive cells, they enter the recirculating pool, moving continuously from the blood into the secondary lymphoid organs, spleen, lymph nodes and Peyer’s patches, from which they return, directly or via efferent lymph, back to the blood (Gowans and Knight 1964).
A, Hamann, S, Rebstock
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Effects of cadmium on lymphocyte activation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1989
The effects of cadmium (Cd) on phytohemoagglutinin or phorbol myristate acetate-induced lymphocyte activation were investigated and a dose-dependent inhibition of cell proliferation was found. Kinetic studies revealed that the Cd-sensitive step is an early event of T cell stimulation. Failure of IL2 secretion and reduction of IL2 receptor expression in
Grazia Cifone M   +7 more
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Lymphocyte Subsets and Activation in Prediabetes

Diabetes, 1986
Peripheral blood lymphocytes were obtained from 65 individuals: 34 nondiabetic patients with islet cell autoantibodies (ICA) (prediabetic phase), 9 patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM), 6 ICA-negative siblings or offsprings of IDDM patients, and 16 ICA-negative controls.
C L, Hitchcock   +4 more
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