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Advanced Science, EarlyView.In this study, a targeting PFKFB4 biomimetic codelivery system is developed to improve paclitaxel efficacy by inducing ferroptosis in SCLC. This system enhances immune cell infiltration and cytokine secretion, activating anti‐tumor immunity. Combined with anti‐PD‐L1, it boosts immune responses, offering a novel therapeutic strategy for overcoming ...
Xiang Liu +9 more
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Advanced Science, EarlyView.Bacterial pneumonia is the sixth leading cause of death. In this study, an inhalable polymeric nanoparticle NPFCPS‐P is developed, which under US stimulation showed high efficacy in the treatment of acute bacterial pneumonia. This nanoplatform would be much less prone to select bacterial resistance and represented a promising measure for antibiotics ...
Lin Wang +6 more
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The Activation of T Lymphocytes
Rheumatic Disease Clinics of North America, 1987The events involved in T cell activation are initiated at the cell surface by the interaction of ligands with specific cell surface receptors on the T cell. Central to antigen-induced activation is the CD3/Ti complex, a complex multi-chain receptor responsible for antigen/MHC recognition and signal transduction. Triggering the CD3/Ti complex results in
Gary A. Koretzky +3 more
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Migration of Activated Lymphocytes [PDF]
, 1993 When lymphocytes leave the primary lymphoid organs as mature but naive cells, they enter the recirculating pool, moving continuously from the blood into the secondary lymphoid organs, spleen, lymph nodes and Peyer’s patches, from which they return, directly or via efferent lymph, back to the blood (Gowans and Knight 1964).
S. Rebstock, A. Hamann
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Metabolism of activated T lymphocytes
Current Opinion in Immunology, 2014Activated T cells undergo metabolic reprogramming which promotes glycolytic flux and lactate production as well as elevated production of lipids, proteins, nucleic acids and other carbohydrates (i.e. induction of biomass) even in the presence of oxygen.
Jason A Maciolek +2 more
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Calcium and lymphocyte activation
Cellular Immunology, 1976Abstract The role of ionized calcium in the early phases of activation of human peripheral blood lymphocytes was evaluated by stimulating the cells with a calcium ionophore A23187 (Lilly) or with mitogenic lections over a broad range of extracellular calcium concentrations ( 1000 μ M ).
Christine M. Parker +2 more
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Cytotoxic Activity of Lymphocytes
The Journal of Immunology, 1972Abstract Antibody to human lymphotoxin was elicited in rabbits immunized with partially purified supernatants of human spleen cells stimulated by phytohemagglutinin; Anti-LT activity, assayed by neutralizing soluble LT toxicity to indicator mouse L cells, is confined to the immunoglobulin fraction of the serum; it cannot be removed by ...
Sharyn M. Walker, Zoltan J. Lucas
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The Activation of Fetal Lymphocytes
Scandinavian Journal of Haematology, 1973Fetal lymphocytes from the cord blood of normal full‐term fetuses can be stimulated in vitro by PHA to transformation and mitotic division. The reaction kinetics differ from those of adult cells, in that the minimum G1 period is about 4 h shorter. However, the cord blood also contains a small number of lymphocytes, which enter the S period very soon ...
Valdemar Skoog +2 more
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