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Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images [PDF]
Cell Reports, 2018 Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images
of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA Abdel-Rahman, Mohamed H., Abeshouse, Adam, Adebamowo, Clement, Adebamowo, Sally N., Agnew, Kathy, Ahn, Keunsoo, Ajani, Jaffer A., Akbani, Rehan, Akeredolu, Teniola, Al-Ahmadie, Hikmat, Albert, Monique, Alexopoulou, Iakovina, Ally, Adrian, Alvaro, Domenico, Anderson, Matthew L., Andry, Chris, Antenucci, Anna, Anur, Pavana, Appelbaum, Elizabeth L., Aredes, Natália D., Armenia, Joshua, Arnaout, Angel, Asa, Sylvia L., Auman, J. Todd, Aymerich, Marta, Aziz, Dina, Bailey, Matthew, Balasundaram, Miruna, Balu, Saianand, Barnett, Gene, Barnholtz-Sloan, Jill S., Barrett, Wendi, Bartlett, John, Bathe, Oliver, Batiste, Rebecca, Baudin, Eric, Baylin, Stephen, Becker, Karl-Friedrich, Beer, David, Behera, Madhusmita, Behrens, Carmen, Bell, Debra, Bell, Sue, Bellair, Michelle, Bennett, Joseph, Benz, Christopher, Berchuck, Andrew, Berger, Ashton C., Bergeron, Alain, Berkowitz, Ross, Bernard, Brady, Beroukhim, Rameen, Beuschlein, Felix, Bifulco, Carlo, Bigner, Darell, Birrer, Michael, Birsoy, Kivanc, Bocklage, Therese, Bodenheimer, Tom, Bondaruk, Jolanta, Bootwalla, Moiz S., Borad, Mitesh, Borgia, Jeffrey A., Bossler, Aaron, Botnariuc, Natalia, Boussioutas, Alex, Bowen, Jay, Bowlby, Reanne, Bowman, Rayleen, Bradford, Carol, Bragazzi, Maria Consiglia, Brat, Daniel J., Breggia, Anne, Brewer, Cathy, Brimo, Fadi, Broaddus, Russell, Brooks, Denise, Broom, Bradley M., Broudy, Thomas, Bryce, Alan H., Bubley, Glenn, Bueno, Raphael, Burnette, Andrew, Caesar-Johnson, Samantha J., Calatozzolo, Chiara, Campo, Elias, Campos, Benito, Caraman, Irina, Cardinale, Vincenzo, Carey, Francis, Carey, Thomas, Carlotti, Carlos Gilberto, Carlsen, Rebecca, Carney, Michael, Carpino, Guido, Carroll, Peter R., Carter, Candace, Carvalho, Andre L., Castle, Erik, Castro, Patricia D., Catto, James, Cebulla, Colleen M., Cernat, Mircea, Chabot, John, Chakravarty, Debyani, Chambwe, Nyasha, Chan, June M., Chan, Timothy A., Chandan, Vishal, Chang, Kyle, Chatila, Walid K., Chemencedji, Inga, Chen, Amy, Chen, Chu, Cheng, Feixiong, Cherniack, Andrew D., Chesla, David, Chevalier, Simone, Cheville, John, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Chung, Ki, Cibulskis, Carrie, Clipca, Adrian, Colman, Howard, Cope, Leslie, Copland, John A., Corcoran, Niall, Cordes, Matthew G., Costello, Tony, Cottingham, Sandra, Couce, Marta, Covington, Kyle, Crain, Daniel, Cramer, Daniel, Creaney, Jenette, Creighton, Chad J., Cuppini, Lucia, Curley, Erin, Cuzzubbo, Stefania, Czerniak, Bogdan, Danilova, Ludmila, Davis, Amy, de Bruijn, Ino, de Carvalho, Ana C., de Krijger, Ronald, De Rienzo, Assunta, De Rose, Agostino, Defreitas, Timothy, Delman, Keith, Demchok, John A., Desjardins, Laurence, Devine, Karen, Deyarmin, Brenda, Dhalla, Noreen, Dhanasekaran, Renumathy, Dhankani, Varsha, Dhir, Rajiv, Dimeco, Francesco, Ding, Li, Dinh, Huyen, Dinkin, Mikhail, Dipersio, John, Disaia, Philip, Doddapaneni, Harshavardhan, Donehower, Lawrence A., Doruc, Serghei, Dos Santos, Jose Sebastião, Dottino, Peter R., Drake, Bettina, Drummond, Jennifer, Drwiega, Paul, Dubina, Michael, Duell, Rebecca, Duffy, Elizabeth R., Eckman, John, Edenfield, W. Jeffrey, Eijckenboom, Wil, Elder, J. Bradley, Engel, Jay, Eschbacher, Jennifer, Esmaeli, Bita, Evason, Kimberley, Facciolo, Francesco, Fan, Cheng, Fan, Huihui, Fantacone-Campbell, J. Leigh, Farnell, Michael, Farver, Carol, Fassnacht, Martin, Fehrenbach, Ashley, Felau, Ina, Feldman, Michael, Feltmate, Colleen, Ferguson, Martin L., Finocchiaro, Gaetano, Flotte, Thomas, Fong, Kwun M., Force, Seth, Forgie, Ian, Frazer, Scott, Fregnani, José H., Fronick, Catrina C., Fujimoto, Junya, Fulop, Jordonna, Fulton, Lucinda A., Fulton, Robert S., Gabra, Hani, Gabriel, Stacey B., Galbraith, Joseph, Gao, Galen F., Gao, Jianjiong, Gardner, Johanna, Gastier-Foster, Julie M., Gaudio, Eugenio, Gehlenborg, Nils, Gerken, Mark, Gershenwald, Jeffrey, Getz, Gad, Ghossein, Ronald, Giama, Nasra, Gibbs, Richard A., Gilbert, Sebastien, Gillis, Ad, Gimenez-Roqueplo, Anne-Paule, Giné, Eva, Giordano, Thomas, Girard, Nicolas, Giuliante, Felice, Glenn, Pat, Glenn, Robert, Godwin, Andrew K., Godwin, Eryn M., Gonzalez, Ana Maria Angulo, Goodman, Marc, Gopalan, Anuradha, Goparaju, Chandra, Gorincioi, Ghenadie, Govindan, Ramaswamy, Graefen, Markus, Grazi, Gianluca, Grizzle, William E., Gross, Benjamin E., Guillermo, Armando López, Guo, Charles, Gupta, Rajarsi, Ha, Gavin, Haddad, Andrea, Hagedorn, Curt H., Hale, Walker, Han, Yi, Hanh, Phan Thi, Hansen, Paul, Harr, Jodi, Hartmann, Arndt, Haydu, Lauren, Hayes, D. Neil, Hayward, Nicholas, Heath, Sharon, Hegde, Apurva M., Heiman, David I., Heins, Zachary J., Henderson, Joel, Hermes, Beth, Hernandez, Brenda, Herold-Mende, Christel, Hersey, Peter, Hess, Julian, Hibshoosh, Hanina, Hilty, Joe, Hinoue, Toshinori, Ho, Thai, Hoadley, Katherine A., Holt, Robert, Hooke, Jeffrey A., Hoon, Dave, Horowitz, Neil, Hou, Le, Houck, John, Hovens, Christopher, Hoyle, Alan P., Hu, Hai, Hu, Jianhong, Huland, Hartwig, Hung, Nguyen Phi, Huntsman, David, Hutter, Carolyn M., Iacocca, Mary, Ittmann, Michael, Jacobus, Laura, Jakrot, Valerie, Janssen, Klaus-Peter, Jefferys, Stuart R., Jimeno, Antonio, Jones, Corbin D., Jones, Steven J. M., Ju, Zhenlin, Juhl, Hartmut, Jungk, Christin, Junker, Kerstin, Kakavand, Hojabr, Kalkanis, Steven, Kanchi, Rupa S., Kandoth, Cyriac, Kang, Koo Jeong, Karlan, Beth Y., Kasaian, Katayoon, Kasapi, Melpomeni, Kastl, Alison, Kebebew, Electron, Kefford, Richard, Kelley, Robin K., Kemp, Rafael, Kendall, Sara, Kendler, Ady, Kendrick, Michael, Khuri, Fadlo, Kibel, Adam, Kim, Jaegil, Knijnenburg, Theo, Knudson, Michael, Knutson, Tina, Kocher, Jean-Pierre, Kohl, Bernard, Kopp, Karla, Korchina, Viktoriya, Korkut, Anil, Korpershoek, Esther, Korst, Robert, Kovatich, Albert J., Kramer, Roger, Kucherlapati, Melanie H., Kucherlapati, Raju S., Kumar, Bahavna, Kundra, Ritika, Kurc, Tahsin, Kvecher, Leonid, Kycler, Witold, La, Konnor, Lacombe, Louis, Ladanyi, Marc, Lai, Phillip H., Laird, Peter W., Landen, Charles N., Landrum, Lisa, Lang, James, Larson, Caroline, Latour, Mathieu, Lau, Kevin, Lawrence, Michael S., Lazar, Alexander J., Lazar, Alexander J., Le, Xuan, Lechan, Ronald, Lee, Darlene, Lee, Jung Il, Lee, Kenneth, Lee, Sandra, Lehman, Norman L., Leinonen, Kalle, Leraas, Kristen M., Levine, Douglas A., Lewis, Lora, Ley, Timothy, Li, Jun, Li, Wei, Liang, Han, Lichtenberg, Tara M., Lin, Pei, Linehan, W. Marston, Ling, Shiyun, Lipp, Eric, Liptay, Michael J., Liu, Jia, Liu, Wenbin, Liu, Xiuping, Liu, Yuexin, Logothetis, Christopher, Lohavanichbutr, Pawadee, Lolla, Laxmi, Long, Georgina, Longatto-Filho, Adhemar, Looijenga, Leendert, Lu, Yiling, Luketich, James, Luna, Augustin, Lyadov, Vladimir, Ma, Deqin, Ma, Yussanne, Madan, Rashna, Maglinte, Dennis T., Magliocca, Kelly, Maithel, Shishir, Mallery, David, Malykh, Andrei, Mandt, Randy, Manikhas, George, Mann, Graham, Mannel, Robert, Mannelli, Massimo, Mardis, Elaine R., Mariamidze, Armaz, Mariani, Odette, Marino, Mirella, Marks, Jeffrey, Marra, Marco A., Martignetti, John A., Martin, Julie, Mattei, Luca, Mayo, Michael, Mccall, Shannon, Mcgraw, Mary, Mckercher, Ginette, Mclellan, Michael D., Mclendon, Roger, Mcpherson, Christopher, Meier, Sam, Melamed, Jonathan, Meng, Shaowu, Meric-Bernstam, Funda, Merola, Roberta, Mes-Masson, Anne-Marie, Metwalli, Adam R., Meyerson, Matthew, Mieczkowski, Piotr A., Mikkelsen, Tom, Milhem, Mohammed, Miller, Christopher A., Miller, Judy, Miller, Michael, Mills, Gordon B., Mirsaidi, Cyrus, Moiseenko, Fedor, Moncrieff, Marc, Moore, Kathleen, Moore, Richard A., Moran, Cesar, Morgan, Margaret, Morris, Scott, Morrison, Carl, Morton, Donna, Mose, Lisle E., Moser, Catherine, Moxley, Katherine, Moyer, Jeffey, Mungall, Andrew J., Mungall, Karen, Mura, Sergiu, Mural, Richard J., Murawa, Dawid, Muto, Michael, Muzny, Donna, Myers, Jerome, Nagorney, David, Nair, Praveen, Naresh, Rashi, Naska, Theresa, Nelson, Mark, Ng, Kwok-Shing, Nguyen, Phuong, Nguyen, Vu, Nissan, Moriah G., Noble, Michael S., Noss, Ardene, Noushmehr, Houtan, O'Brien, Daniel, O'Neill, Brian Patrick, Ochoa, Angelica, Olabode, Oluwole, Olson, Jeffrey J., Omberg, Larsson, Oosterhuis, Wolter, Ostrom, Quinn T., Owonikoko, Taofeek, Pacak, Karel, Paklina, Oxana, Parfitt, Jeremy, Park, Joong-Won, Parker, Joel S., Pass, Harvey, Patel, Tushar, Paulauskis, Joseph, Pennell, Nathan A., Penny, Robert, Perin, Alessandro, Perou, Amy H., Perou, Charles M., Petersen, Gloria, Peterson, Lisa, Peto, Myron, Phillips, Joanna, Phillips, Sarah M., Phu, Bui Duc, Piché, Alain, Pickens, Alan, Pihl, Todd, Pilarski, Robert, Pinero, Edna M. 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S., Simko, Jeffry, Simon, Ronald, Simons, Janae V., Singer, Samuel, Singh, Bhuvanesh, Singh, Pankaj, Singh, Rosy, Sipahimalani, Payal, Skelly, Tara, Sloan, Andrew E., Slotta-Huspenina, Julia, Smallridge, Robert, Smith, Jennifer, Smith-McCune, Karen, Smolenski, Kathy, Smyrk, Thomas, Sofia, Heidi J., Soloway, Matthew G., Somiari, Stella, Sood, Anil, Spellman, Paul, Spillane, Andrew, Stancul, Irina, Stanton, Melissa, Staugaitis, Susan M., Steele, Ruth, Stepa, Serghei, Stern, Marc-Henri, Stoehr, Christine, Stoehr, Robert, Stoop, Hans, Stretch, Onathan, Stuart, Joshua M., Su, Tao, Sumer, S. Onur, Sun, Qiang, Sun, Yichao, Swanson, Patricia, Swisher, Elizabeth, Synott, Maria, Tam, Angela, Tamakawa, Raina, Tamboli, Pheroze, Tan, Donghui, Tang, Yufang, Tarnuzzer, Roy, Taubert, Helge, Tavobilov, Mikhail, Taylor, Barry S., Tcaciuc, Diana, Tennstedt, Pierre, Thiessen, Nina, Thomas, George, Thompson, Eric, Thompson, John, Thompson, R. Houston, Thompson, Timothy, Thorp, Richard, Thorsson, Vesteinn, Thorsson, Vésteinn, Tien, Nguyen Viet, Timmers, Henri, Tirapelli, Daniela, Tischler, Arthur, Torbenson, Michael, Troncoso, Patricia, Tsao, Anne, Tse, Kane, Tucker, Kelinda, Têtu, Bernard, Unterberg, Andreas, Urba, Walter, Valdivieso, Federico, Van Arnam, John, Van Bang, Nguyen, Van Den Berg, David J., van Kessel, Kim E., Van Meir, Erwin G., Van Tine, Brian, Vandenberg, Scott, Veluvolu, Umadevi, Vicha, Ales, Vidal, Daniel O., Vocke, Cathy D., Voet, Doug, von Deimling, Andreas, Voronina, Olga, Wach, Sven, Wakely, Paul, Waldmann, Jens, Walker, Joan, Wan, Yunhu, Wang, Jing, Wang, Jioajiao, Wang, Linghua, Wang, Min, Wang, Timothy, Wang, Zhining, Warnick, Ronald, Weinstein, John N., Weisenberger, Daniel J., Wentzensen, Nicolas, Westervelt, Peter, Wheeler, David A., Wilkerson, Matthew D., Williams, Felicia, Wilmott, James, Wilson, Richard K., Wise, Lisa, Wistuba, Ignacio, Wiznerowicz, Maciej, Wolf, Gregory, Wolinsky, Yingli, Wong, Christopher K., Wong, Tina, Worrell, Robert, Wu, Ye, Wullich, Bernd, Xi, Liu, Yang, Hannah, Yang, Ian, Yang, Ju Dong, Yang, Liming, Yau, Christina, Yena, Peggy, Zach, Leigh Anne, Zaren, Howard, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Hailei, Zhang, Hongxin, Zhang, Hongzheng, Zhang, Jiashan (Julia), Zhang, Jiexin, Zhang, Lizhi, Zhang, Wei, Zhao, Fengmei, Zhao, Tianhao, Zhou, Wanding, Zmuda, Erik, Zuna, Rosemary, Zwarthoff, Ellen C. +740 morecore +6 more sourcesTumor HPV status, level of regulatory T cells and macrophage infiltration predict up to 20-year non-disease-specific survival in oropharynx squamous cell carcinoma patients [PDF]
Biomedicines, 2022 Oropharynx squamous cell carcinoma (OPSCC) is of special interest because human papilloma virus (HPV) and/or smoking cause this disease. Influxes of inflammatory cells into such tumors are known to vary with prognoses.Aarstad, Hans Jørgen, Berge, Jan Erik, Haave, Hilde, Helgeland, Lars, Ljøkjel, Borghild, Lybak, Helene, Moe, Svein Erik Emblem, Vintermyr, Olav Karsten +7 morecore +3 more sourcesTumor-Infiltrating Lymphocytes and Their Prognostic Value in Cutaneous Melanoma [PDF]
Frontiers in Immunology, 2020 Recent breakthroughs in tumor immunotherapy such as immune checkpoint blockade (ICB) antibodies, have demonstrated the capacity of the immune system to fight cancer in a number of malignancies such as melanoma and lung cancer. The numbers, localization and phenotypes of tumor-infiltrating lymphocytes (TIL) are not only predictive of response to ...Maibach, Fabienne, Sadozai, Hassan, Jafari, S. Morteza Seyed, Hunger, Robert E., Schenk, Mirjam +4 moreopenaire +6 more sourcesTumor-Infiltrating Lymphocytes in the Checkpoint Inhibitor Era
Current Hematologic Malignancy Reports, 2019 Checkpoint inhibitors block co-inhibitory signals which serves to promote T cell activation/reinvigoration in the periphery and tumor microenvironment. A brief historical background as well as a summary of key observations related to the composition and prognostic value of tumor-infiltrating lymphocytes (TILs) is discussed.Solid tumor patients that ...Gerald P. Linette, Beatriz M. Carrenoopenaire +5 more sourcesTumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer
JCO Precision Oncology, 2021 PURPOSE To characterize the relationship between tumor-infiltrating lymphocytes (TIL), tumor mutational burden (TMB), and genetic alterations in microsatellite stable (MSS), microsatellite instability (MSI), or mutant POLE/POLD1 colon cancer.Ajaratu Keshinro, Chad M. Vanderbilt, Jin K. Kim, C. Firat, Ching-Tung Chen, R. Yaeger, K. Ganesh, N. Segal, M. Gonen, J. Shia, Z. Stadler, M. Weiser +11 moresemanticscholar +1 more sourcePrognostic and Predictive Value of Immune-Related Gene Expression Signatures vs Tumor-Infiltrating Lymphocytes in Early-Stage ERBB2/HER2-Positive Breast Cancer
JAMA Oncology, 2023 Key Points Question Which immune-related biomarker provides the most valuable information to predict pathologic complete response and event-free survival in patients with early-stage ERBB2/HER2-positive breast cancer: tumor-infiltrating lymphocytes ...A. Fernandez-Martinez, T. Pascual, Baljit Singh, P. Nuciforo, N. Rashid, K. Ballman, J. Campbell, K. Hoadley, P. Spears, L. Paré, F. Brasó-Maristany, N. Chic, I. Krop, A. Partridge, J. Cortés, A. Llombart-Cussac, A. Prat, C. Perou, L. Carey +18 moresemanticscholar +1 more source
