Results 11 to 20 of about 17,417 (215)

Visualizing lymphocytic choriomeningitis virus infection in cells and living mice [PDF]

iScience, 2022
Summary: Mammarenavirus are a large family of enveloped negative-strand RNA viruses that include several agents responsible for severe hemorrhagic fevers.
Yuxi Wen, Huan Xu, Weiwei Wan, Weijuan Shang, Runming Jin, Fen Zhou, Heng Mei, Jingshi Wang, Gengfu Xiao, Hongbo Chen, Xiaoyan Wu, Leike Zhang   +11 more
doaj   +2 more sources

2-Deoxy-D-glucose inhibits lymphocytic choriomeningitis virus propagation by targeting glycoprotein N-glycosylation [PDF]

Virology Journal, 2023
Background Increased glucose uptake and utilization via aerobic glycolysis are among the most prominent hallmarks of tumor cell metabolism. Accumulating evidence suggests that similar metabolic changes are also triggered in many virus-infected cells ...
Lucia Baďurová, Katarína Polčicová, Božena Omasta, Ingrid Ovečková, Eva Kocianová, Jana Tomášková   +5 more
doaj   +2 more sources

Persistence, spillover, and evolution of co-occurring lineages of lymphocytic choriomeningitis virus. [PDF]

Virus Evol
Mehl C, Adeyemi OA, Möhrer FJ, Wylezich C, Sander S, Schmidt K, Geiger C, Schauerte N, Wurr S, Mätz-Rensing K, Nesseler A, von Graffenried TA, Parker Morgan A, Oestereich L, Günther S, Beer M, Klein C, Cadar D, Kerber R, Höper D, Reiche S, Heckel G, Ulrich RG.   +22 more
europepmc   +2 more sources

Local Maintenance and Genomic Diversity of Lymphocytic Choriomeningitis Virus in Natural Populations of House Mice in the Czech Republic Over a 24-Year Period. [PDF]

Zoonoses Public Health
ABSTRACT Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent‐borne zoonotic virus primarily infecting house mice. The virus can be highly pathogenic, particularly in immunocompromised individuals and in congenital infections. LCMV is distributed worldwide but shows local clustering, probably due to the highly structured populations of its ...
Jezkova I, Fornůsková A, Ďureje Ľ, Macholán M, Piálek J, de Bellocq JG.   +5 more
europepmc   +2 more sources

Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET

Nature Communications, 2022
The innate antiviral immune response is an important defense against infection. Here, the authors show that leukocyte cell-derived chemotaxin 2 (LECT2) promotes RIG-I-mediated innate immune responses by preventing its degradation, and inhibits ...
Takayoshi Shirasaki, Satoshi Yamagoe, Tetsuro Shimakami, Kazuhisa Murai, Ryu Imamura, Kiyo-Aki Ishii, Hiroaki Takayama, Yukako Matsumoto, Natsumi Tajima-Shirasaki, Naoto Nagata, Ryogo Shimizu, Souma Yamanaka, Atsushi Abe, Hitoshi Omura, Kazunori Kawaguchi, Hikari Okada, Taro Yamashita, Tomoki Yoshikawa, Kazuhiro Takimoto, Motoko Taharaguchi, Shogo Takatsuka, Yoshitsugu Miyazaki, Toshikatsu Tamai, Yamato Tanabe, Makoto Kurachi, Yasuhiko Yamamoto, Shuichi Kaneko, Kunio Matsumoto, Toshinari Takamura, Masao Honda   +29 more
doaj   +1 more source

Slow viral propagation during initial phase of infection leads to viral persistence in mice

Communications Biology, 2021
Using different strains of the lymphocytic choriomeningitis virus (LCMV), Xu, Wang et al. show that a slow viral propagation limits type I interferon (IFN-I) production and viral persistence in mice.
Haifeng C. Xu, Ruifeng Wang, Prashant V. Shinde, Lara Walotka, Anfei Huang, Gereon Poschmann, Jun Huang, Wei Liu, Kai Stühler, Heiner Schaal, Andreas Bergthaler, Aleksandra A. Pandyra, Cornelia Hardt, Karl S. Lang, Philipp A. Lang   +14 more
doaj   +1 more source

Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment

Nature Communications, 2021
Lymphocytic choriomeningitis virus (LCMV)-based viral vectors have been shown to induce potent antitumor immune responses. Here the authors show that a LCMV-based vaccine vector remodels the tumor-associated fibroblastic stroma, sustaining CD8+ T cell ...
Sandra S. Ring, Jovana Cupovic, Lucas Onder, Mechthild Lütge, Christian Perez-Shibayama, Cristina Gil-Cruz, Elke Scandella, Angelina De Martin, Urs Mörbe, Fabienne Hartmann, Robert Wenger, Matthias Spiegl, Andrej Besse, Weldy V. Bonilla, Felix Stemeseder, Sarah Schmidt, Klaus K. Orlinger, Philippe Krebs, Burkhard Ludewig, Lukas Flatz   +19 more
doaj   +1 more source

Novel Arenavirus Infection in Humans, United States

Emerging Infectious Diseases, 2011
Immunoglobulin G against Whitewater Arroyo virus or lymphocytic choriomeningitis virus was found in 41 (3.5%) of 1,185 persons in the United States who had acute central nervous system disease or undifferentiated febrile illnesses.
Mary Louise Milazzo, Grant L. Campbell, Charles F. Fulhorst   +2 more
doaj   +1 more source

Microcephaly Caused by Lymphocytic Choriomeningitis Virus

Emerging Infectious Diseases, 2017
We report congenital microencephaly caused by infection with lymphocytic choriomeningitis virus in the fetus of a 29-year-old pregnant women at 23 weeks’ gestation.
Maia Delaine, Anne-Sophie Weingertner, Antoine Nougairede, Quentin Lepiller, Samira Fafi-Kremer, Romain Favre, Rémi N. Charrel   +6 more
doaj   +1 more source

Lymphocytic choriomeningitis virus [PDF]

Canadian Medical Association Journal, 2005
Background and epidemiology: In May 2005, the US Centers for Disease Control and Prevention (CDC) reported cases of lymphocytic choriomeningitis virus (LCMV) infection in 4 people who had received transplants of the liver, lungs or a kidney from a single common donor.
openaire   +2 more sources