Results 31 to 40 of about 69,598 (194)

Impaired antibody response causes persistence of prototypic T cell-contained virus [PDF]

, 2009
CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control
André Fitsche, Bruno Eschli, Lukas Flatz, Senn, Beatrice M., Marylise Fernandez, Ahmed N Hegazy, Verbeek, J Sjef, Eschli, Bruno, Fink, Katja, Rami Sommerstein, Doron Merkler, Daniel D Pinschewer, Katja Fink, Siegrist, Claire-Anne, Odermatt, Bernhard, Andreas Bergthaler, Horvath, Edit, Fitsche, André, Bergthaler, Andreas, Claire-Anne Siegrist, Holdener, Martin, Beatrice M Senn, Verbeek, J. Sjef, Admar Verschoor, J Sjef Verbeek, Verschoor, Admar, Merkler, Doron, Edit Horvath, Pinschewer, Daniel, Martin Holdener, Bernhard Odermatt, Flatz, Lukas, Pinschewer, Daniel D., Sommerstein, Rami, Hegazy, Ahmed N., Fernandez, Marylise, Merkler D, Verbeek JS, Siegrist CA, Fitsche A, Flatz L, Verschoor A, Holdener M, Bergthaler, A;Flatz, L;Verschoor, A;Hegazy, AN;Holdener, M;Fink, K;Eschli, B;Merkler, D;Sommerstein, R;Horvath, E;Fernandez, M;Fitsche, A;Senn, BM;Verbeek, JS;Odermatt, B;Siegrist, CA;Pinschewer, DD, Senn BM, Pinschewer DD, Odermatt B, Sommerstein R, Fernandez M, Fink K, Eschli B, Bergthaler A, Hegazy AN, Horvath E   +53 more
core   +1 more source

Host Range and Genetic Diversity of Arenaviruses in Rodents, United Kingdom

Emerging Infectious Diseases, 2008
During a study to extend our knowledge of the host range and genetic diversity of arenaviruses in Great Britain, 66 of 1,147 rodent blood samples tested for antibody, and 127 of 482 tested by PCR, were found positive. All sequences most closely resembled
Kim R. Blasdell, Stuart D. Becker, Jane Hurst, Mike Begon, Malcolm Bennett   +4 more
doaj   +1 more source

Lymphocytic Choriomeningitis Virus Meningitis, New York, NY, USA, 2009

Emerging Infectious Diseases, 2010
We describe a case of lymphocytic choriomeningitis virus (LCMV) meningitis in a New York, NY, resident who had no apparent risk factors. Clues leading to the diagnosis included aseptic meningitis during winter and the finding of hypoglycorrachia and ...
Deborah S. Asnis, Owen Muana, Do Gyun Kim, Minerva Garcia, Pierre E. Rollin, Sally Slavinski   +5 more
doaj   +1 more source

Dnmt3a Mutations Limit Normal and Autoreactive CD4+ T Follicular Helper Responses and Attenuate T Cell–Driven Joint Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased markers of inflammation. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

Drivers of Host–Pathogen Community Assemblages in European Forests and Urban Green Spaces

Integrative Zoology, EarlyView.
ABSTRACT Despite advances in understanding infectious diseases, the persistence and re‐emergence of wildlife pathogens continue to raise public and veterinary health concerns. This study investigates the relationship between biodiversity and rodent‐borne diseases in Europe, focusing on habitat alterations and their impact on rodent diversity.
Vincent Sluydts, Marie Bouilloud, Maxime Galan, Hussein Alburkat, Anaïs Bordes, Vincent Bourret, Valeria Colombo, Luc DeBruyn, Lara Dutra, Jana Eccard, Jasmin Firozpoor, Romain Gallet, Maciej Grzybek, Heikki Henttonen, Jens Jacob, Andrew McManus, Tarja Sironen, Peter Stuart, Caroline Tatard, Benjamin Roche, Herwig Leirs, Nathalie Charbonnel   +21 more
wiley   +1 more source

Envelope Exchange for the Generation of Live-Attenuated Arenavirus Vaccines. [PDF]

PLoS Pathogens, 2006
Arenaviruses such as Lassa fever virus cause significant mortality in endemic areas and represent potential bioterrorist weapons. The occurrence of arenaviral hemorrhagic fevers is largely confined to Third World countries with a limited medical ...
Andreas Bergthaler, Nicolas U Gerber, Doron Merkler, Edit Horvath, Juan Carlos de la Torre, Daniel D Pinschewer   +5 more
doaj   +2 more sources

LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION

Problems of Infectious and Parasitic Diseases
Background: Lymphocytic choriomeningitis virus (LHMV) infection is a neglected rodent-borne zoonotic infection but it is found all over the world because of the cosmopolitan distribution of its reservoirs.
Teodora Gladnishka, Iva Trifonova, Vladislava Ivanova, Iva Christova   +3 more
doaj   +1 more source

Characterization of a nonvirulent variant of lymphocytic choriomeningitis virus [PDF]

, 1982
A cold-adapted, nonvirulent variant of the Armstrong strain of lymphocytic choriomeningitis virus was isolated from infected L929 cells maintained at 25° C.
Brayton, P. R., Maassab, Hunein F.
core   +1 more source

Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential

Clinical &Experimental Allergy, EarlyView.
Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole, Ingrid Laing, Ryan Mead‐Hunter, Peter Le Souef, Guicheng Zhang   +4 more
wiley   +1 more source

A guide to studying tumour‐T‐cell interactions using in vitro coculture assays

The FEBS Journal, EarlyView.
In vitro tumour‐T‐cell coculture systems provide a controlled way to study how T cells recognise and kill tumour cells. Different tumour models can be combined with antigen‐specific TCR or CAR T cells, while antigen presentation, cytokines, drugs and tumour genetics can be manipulated.
Nooshin Khoshdoozmasouleh, Conor J. Kearney   +1 more
wiley   +1 more source