Results 41 to 50 of about 69,598 (194)
Cell Reports, 2020 Summary: Control of established chronic lymphocytic choriomeningitis virus (LCMV) infection requires the production of neutralizing antibodies, but it remains unknown how the ensemble of antibodies evolves during ongoing infection.
Nike Julia Kräutler +15 more
doaj +1 more source
CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection
Nature Communications, 2018 Chronic viral infections are frequently associated with the dysfunction of CD8+ T cells which includes loss of function and results in CD8+ T cell exhaustion.
Vishal Khairnar +20 more
doaj +1 more source
Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy [PDF]
, 2009 Background: Glioblastoma is the most frequent and most malignant primary brain tumor with a poor prognosis. The translation of therapeutic strategies for glioblastoma from the experimental phase into the clinic has been limited by insufficient animal ...
Oleg Tsinkalovsky +23 more
core +2 more sources
Advanced Science, Volume 13, Issue 57, 14 October 2026.ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang +13 more
wiley +1 more source
Lymphocytic choriomeningitis (LCM) [PDF]
Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.The primary host of LCMV is the common house ...
core +2 more sources
Investigating CD8 T Cell Exhaustion in Chronic LCMV Infection by Flow Cytometry
Current Protocols, Volume 6, Issue 10, October 2026.Abstract CD8 T cells and the process of T cell exhaustion are central topics in both basic immunology and translational research, including clinical applications. Here, we provide a comprehensive, step‐by‐step guide to investigate CD8 T cells in murine in vivo lymphocytic choriomeningitis virus (LCMV) infection models.
Dominique Stark +5 more
wiley +1 more source
Beyond Exhaustion: The RNA Regulatory Layer of Tissue‐Instructed T Cell Dysfunction
European Journal of Immunology, Volume 56, Issue 10, October 2026.CD8+ T cell dysfunction arises through classical exhaustion after priming by professional antigen‐presenting cells, and through extra‐lymphoid priming by non‐professional cells – exemplified by the liver, where hepatocyte priming yields a checkpoint‐refractory state.
Francesco Andreata +3 more
wiley +1 more source
Лимфоцитен хориоменингит – клиничен случай
Българска неврология, 2023 Lymphocytic choriomeningitis virus е един от причинителите на неврологични заболявания при хора. Заразяването с вируса се осъществява посредством контакт с миши екскременти.
Sashka Zhelyazkova +3 more
doaj
Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses
Cell Reports, 2020 Summary: Persistent viral infections subvert key elements of adaptive immunity. To compare germinal center (GC) B cell responses in chronic and acute lymphocytic choriomeningitis virus infection, we exploit activation-induced deaminase (AID) fate ...
Bénédict Fallet +14 more
doaj +1 more source
Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review
Tropical Medicine and Infectious Disease, 2021 Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent-borne zoonotic virus distributed worldwide. Since serologic assays are limited to several laboratories, the disease has been underreported, often making it difficult to determine incidence ...
Tatjana Vilibic-Cavlek +9 more
doaj +1 more source