Results 61 to 70 of about 25,376 (203)

Shared determinants between virus-infected and trinitrophenyl-conjugated H-2-identical target cells detected in cell-mediated lympholysis [PDF]

, 1976
Infection of H-2-identical mice with either lymphocytic choriomeningitis (LCM) virus, vaccinia virus, or paramyxo (Sendai) virus resulted in the generation of specifically sensitized cytotoxic T lymphocytes (CTL).
Bevan, Canty, Doherty, Doherty, Ertl, Forman, Gordon, Herberman, Koszinowski, Pfizenmaier, Pfizenmaier, Pfizenmaier, Shearer, Shreffler, Wagner, Wekerle, Zinkernagel   +16 more
core   +1 more source

BCR–ABL1 Drives Transcriptional Reprogramming of Chronic Myeloid Leukemia Cells for Immune Evasion Through C/EBPβ

MedComm, Volume 7, Issue 5, May 2026.
There is global immunosuppression during CML initiation and progression, which is directly driven by BCR–ABL1 expressing CML cells. On one hand, the BCR–ABL1 oncogene drives the differentiation of leukemia cells toward the neutrophil lineage. On the other hand, the oncogene also transcriptionally activates master immune regulators, including arginase ...
Xiaocui Lu, Hui Fang, Yuan Liu, Chang Liu, Xuexiu Fang, Atsuko Matsunaga, Stephanie F. Mori, Ting Zhang, Gavin Wang, George I. Zhou, Miao Yu, Haocheng Ding, Jorge Cortes, Bo Cheng, Tianxiang Hu   +14 more
wiley   +1 more source

High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival. [PDF]

, 2016
Chronic infections induce T cells showing impaired cytokine secretion and up-regulated expression of inhibitory receptors such as PD-1. What determines the acquisition of this chronic phenotype and how it impacts T cell function remain vaguely understood.
Alter, Angelosanto, Badovinac, Barber, Battegay, Bengsch, Bengsch, Beura, Blackburn, Blackburn, Chu, Cornberg, Daniel D. Pinschewer, Daniel T. Utzschneider, David Barras, Day, Dietmar Zehn, Doedens, Elsaesser, Enouz, Flatz, Flatz, Francesca Alfei, Frebel, Fröhlich, Harari, Hertoghs, Jin, Jin, Johnson, Klenerman, Kunz, Legat, Lichterfeld, Matloubian, Mauro Delorenzi, Moskophidis, Mueller, Murali-Krishna, Nakamoto, Odorizzi, Paley, Patrick Roelli, Pauken, Pircher, Puglielli, Radziewicz, Schietinger, Schmitz, Sevilla, Smelt, Speiser, Stephanie Darbre, Utzschneider, Viganò, Vijaykumar Chennupati, Virgin, Wherry, Wherry, Wherry, Williams, Yi, Zajac, Zehn, Zehn, Zehn, Zehn   +66 more
core   +2 more sources

Mixed Signals: T Cells as Architects of IgE Immunity

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney, Wallace P. Bezerra, Stephanie C. Eisenbarth, Adam Williams   +3 more
wiley   +1 more source

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 20, 9 April 2026.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

Solid Organ Transplant–associated Lymphocytic Choriomeningitis, United States, 2011

Emerging Infectious Diseases, 2012
Three clusters of organ transplant–associated lymphocytic choriomeningitis virus (LCMV) transmissions have been identified in the United States; 9 of 10 recipients died. In February 2011, we identified a fourth cluster of organ transplant–associated LCMV
Adam MacNeil, Ute Ströher, Eileen Farnon, Shelley Campbell, Deborah Cannon, Christopher D. Paddock, Clifton P. Drew, Matthew Kuehnert, Barbara Knust, Robert Gruenenfelder, Sherif R. Zaki, Pierre E. Rollin, Stuart T. Nichol   +12 more
doaj   +1 more source

Neutralization of IFN-γ reverts clinical and laboratory features in a mouse model of macrophage activation syndrome. [PDF]

, 2018
BACKGROUND: The pathogenesis of macrophage activation syndrome (MAS) is not clearly understood: a large body of evidence supports the involvement of mechanisms similar to those implicated in the setting of primary hemophagocytic lymphohistiocytosis ...
Bracaglia, Claudia, Caiello, Ivan, Chatel, Laurence, De Min, Cristina, Fabrizio De Benedetti, And, Ferlin, Walter G., Grom, Alexei A., Marasco, Emiliano, Pascarella, Antonia, Prencipe, Giusi, Strippoli, Raffaele   +10 more
core   +1 more source

Increased Constitutive Interferon‐β Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein

European Journal of Immunology, Volume 56, Issue 4, April 2026.
Constitutive interferon (IFN) production is regulated by microbiota and essential for optimal immune responses. Here, we demonstrate that expression of the glycoprotein of LCM virus upregulates constitutive IFN‐β levels and IFN‐stimulated genes (ISGs) in transgenic mice.
Hanspeter Pircher, Oliver S. Thomas, Anne S. Haefke, Annette Oxenius, Thomas Boehm   +4 more
wiley   +1 more source

Pet Rodents and Fatal Lymphocytic Choriomeningitis in Transplant Patients

Emerging Infectious Diseases, 2007
In April 2005, 4 transplant recipients became ill after receiving organs infected with lymphocytic choriomeningitis virus (LCMV); 3 subsequently died. All organs came from a donor who had been exposed to a hamster infected with LCMV.
Brian R. Amman, Boris I. Pavlin, Cesar G. Albariño, James A. Comer, Bobbie R. Erickson, Jennifer B. Oliver, Tara K. Sealy, Martin J. Vincent, Stuart T. Nichol, Christopher D. Paddock, Abbigail J. Tumpey, Kent D. Wagoner, R. David Glauer, Kathleen A. Smith, Kim A. Winpisinger, Melody S. Parsely, Phil Wyrick, Christopher H. Hannafin, Utpala Bandy, Sherif Zaki, Pierre E. Rollin, Thomas G. Ksiazek   +21 more
doaj   +1 more source

Arenavirus budding resulting from viral-protein-associated cell membrane curvature [PDF]

, 2013
Viral replication occurs within cells, with release (and onward infection) primarily achieved through two alternative mechanisms: lysis, in which virions emerge as the infected cell dies and bursts open; or budding, in which virions emerge gradually from
Abelson HT, Benjamin W. Neuman, Cheng RH, Coronel EC, Dalton A, David Schley, Dawkins R, Ghosal S, Harty RN, Justice PA, Lehmann-Grube F, Li Y, Murphy FA, Press WH, Puffer BA, Robert J. Whittaker, Schalich J, Suomalainen M, Weldon R   +18 more
core   +1 more source