Results 21 to 30 of about 693,895 (386)

Synergistic regulation of Notch signaling by different O-glycans promotes hematopoiesis

Frontiers in Immunology, 2023
Glycosylation of Notch receptors by O-fucose glycans regulates Notch ligand binding and Notch signaling during hematopoiesis. However, roles in hematopoiesis for other O-glycans that modify Notch receptors have not been determined.
Ankit Tanwar, Pamela Stanley
doaj   +1 more source

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors.

New England Journal of Medicine, 2020
BACKGROUND Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has shown remarkable clinical efficacy in B-cell cancers. However, CAR T cells can induce substantial toxic effects, and the manufacture of the cells is complex.
E. Liu, D. Marin, P. Banerjee, H. Macapinlac, P. Thompson, R. Başar, Lucila Nassif kerbauy, Bethany J Overman, P. Thall, Mecit Kaplan, Vandana Nandivada, I. Kaur, A. N. Nunez Cortes, K. Cao, M. Daher, C. Hosing, E. Cohen, P. Kebriaei, R. Mehta, S. Neelapu, Y. Nieto, Michael Wang, W. Wierda, M. Keating, Richard Champlin, E. Shpall, K. Rezvani   +26 more
semanticscholar   +1 more source

Innate lymphoid cells and cancer

Nature Immunology, 2022
The innate lymphoid cell (ILC) family is composed of natural killer (NK) cells, ILC1, ILC2 and ILC3, which participate in immune responses to virus, bacteria, parasites and transformed cells.
N. Jacquelot, Cyril Seillet, É. Vivier, Gabrielle T. Belz   +3 more
semanticscholar   +1 more source

Genomic Profiling for Clinical Decision Making in Lymphoid Neoplasms.

Blood, 2022
With the introduction of large-scale molecular profiling methods and high-throughput sequencing technologies, the genomic features of most lymphoid neoplasms have been characterized at an unprecedented scale.
L. de Leval, Ash A. Alizadeh, P. Bergsagel, E. Campo, A. Davies, A. Dogan, J. Fitzgibbon, S. Horwitz, A. Melnick, W. Morice, Ryan D. Morin, B. Nadel, S. Pileri, R. Rosenquist, D. Rossi, I. Salaverria, C. Steidl, S. Treon, A. Zelenetz, R. Advani, C. Allen, S. Ansell, W. Chan, J. Cook, L. Cook, F. d'Amore, S. Dirnhofer, M. Dreyling, K. Dunleavy, A. Feldman, F. Fend, P. Gaulard, P. Ghia, J. Gribben, O. Hermine, D. Hodson, E. Hsi, G. Inghirami, E. Jaffe, K. Karube, K. Kataoka, W. Klapper, W. Kim, R. King, Y. Ko, A. LaCasce, G. Lenz, Iñaki Martin-Subero, M. Piris, S. Pittaluga, L. Pasqualucci, L. Quintanilla‐Martinez, S. Rodig, A. Rosenwald, G. Salles, J. San-Miguel, K. Savage, L. Sehn, G. Semenzato, L. Staudt, S. Swerdlow, C. Tam, J. Trotman, J. Vose, O. Weigert, W. Wilson, J. Winter, Catherine J. Wu, P. Zinzani, E. Zucca, A. Bagg, D. Scott   +71 more
semanticscholar   +1 more source

Regulation of myeloid and lymphoid cell development by O-glycans on Notch

Frontiers in Molecular Biosciences, 2022
Notch signaling via NOTCH1 stimulated by Delta-like ligand 4 (DLL4) is required for the development of T cells in thymus, and NOTCH2 stimulated by Notch ligand DLL1 is required for the development of marginal zone (MZ) B cells in spleen.
Pamela Stanley, Ankit Tanwar
doaj   +1 more source

Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression

Cell Reports, 2015
Primary mediastinal large B cell lymphoma (PMBCL) is an aggressive non-Hodgkin’s lymphoma, predominantly affecting young patients. We analyzed 45 primary PMBCL tumor biopsies and 3 PMBCL-derived cell lines for the presence of genetic alterations ...
Anja Mottok, Bruce Woolcock, Fong Chun Chan, King Mong Tong, Lauren Chong, Pedro Farinha, Adèle Telenius, Elizabeth Chavez, Suvan Ramchandani, Marie Drake, Merrill Boyle, Susana Ben-Neriah, David W. Scott, Lisa M. Rimsza, Reiner Siebert, Randy D. Gascoyne, Christian Steidl   +16 more
doaj   +1 more source

Development and function of regulatory innate lymphoid cells

Frontiers in Immunology, 2022
Innate lymphoid cells (ILCs) are a critical element of the innate immune system and are potent producers of pro-inflammatory cytokines. Recently, however, the production of the anti-inflammatory cytokine IL-10 has been observed in all ILC subtypes (ILC1s,
Christopher M. Thomas, R. Stokes Peebles, R. Stokes Peebles, R. Stokes Peebles   +3 more
doaj   +1 more source

Potential for Cell-Mediated Immune Responses in Mouse Models of Pelizaeus-Merzbacher Disease

Brain Sciences, 2013
Although activation of the innate and adaptive arms of the immune system are undoubtedly involved in the pathophysiology of neurodegenerative diseases, it is unclear whether immune system activation is a primary or secondary event.
Cherie M. Southwood, Bozena Fykkolodziej, Fabien Dachet, Alexander Gow   +3 more
doaj   +1 more source

High efficacy of intensive immunochemotherapy for primary mediastinal B-cell lymphoma with prolonged follow up

Scientific Reports, 2022
Primary mediastinal B-cell lymphoma (PMBL) is currently curable in 85–95% of patients. Treatment regimens frequently used include RCHOP ± radiotherapy, DAEPOCH-R, or occasionally more intensive protocols.
Joanna Romejko-Jarosinska, Beata Ostrowska, Anna Dabrowska-Iwanicka, Katarzyna Domanska-Czyz, Grzegorz Rymkiewicz, Ewa Paszkiewicz-Kozik, Robert Konecki, Anna Borawska, Agnieszka Druzd-Sitek, Elzbieta Lampka, Wlodzimierz Osiadacz, Michal Osowiecki, Lidia Popławska, Monika Swierkowska, Lukasz Targonski, Joanna Tajer, Grazyna Lapinska, Malwina Smorczewska, Jan Walewski   +18 more
doaj   +1 more source

Management of a case of Castleman’s disease coexisting with or occurring after transplanted Hodgkin’s lymphoma

Romanian Journal of Laboratory Medicine, 2023
Castleman’s disease is a benign lymphoproliferative disorder. The coexistence of Hodgkin’s lymphoma and multicentric Castle-man’s disease is a rare phenomenon. We discuss a case of a 48-year-old female patient who had been in the records of the Colentina
Andreescu Mihaela, Zurac Sabina, Lacatusu Andreea, Tudor Andrei T., Ilie Nicoleta, Tirlea Laura G., Ionescu Rozeta, Popov Viola M., Tănase Alina D.   +8 more
doaj   +1 more source