Results 31 to 40 of about 18,116 (162)

COX‐2 in lung cancer: Mechanisms, development, and targeted therapies

Chronic Diseases and Translational Medicine, Volume 10, Issue 4, Page 281-292, December 2024.
COX‐2 functions in the tumor microenvironment. Abstract Lung cancer (LC) is the leading cause of cancer‐related death worldwide, with non‐small cell lung cancer (NSCLC) comprising 85% of all cases. COX‐2, an enzyme induced significantly under stress conditions, catalyzes the conversion of free arachidonic acid into prostaglandins.
Xueqi Liu, Junli Zhang, Wenwu Sun, Jianping Cao, Zhuang Ma   +4 more
wiley   +1 more source

Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1 [PDF]

, 1985
We investigated the role of T cell cytotoxicity inducing factor 1 (TCF1) in the induction of a cytotoxic T cell response. We found that help-deficient thymocyte cultures supplied with saturating amounts of purified IL 2 did not develop CTL in a 5-day ...
Diamantstein, T., Dröge, W., Falk, Werner, Kaltmann, B., Katzer, B., Krammer, P. H., Männel, D. N.   +6 more
core  

Translation of mRNA for human lymphotoxin in microinjected Xenopus oocytes [PDF]

, 1984
Synthesis and secretion of biologically active human lymphotoxin (LT) can be detected in Xenopus laevis oocytes following their inoculation with poly(A+) RNA from human stimulated peripheral blood lymphocytes, but not in oocytes inoculated with RNA from ...
Budilovsky, Sylvia, Hahn, Talia, Wallach, David   +2 more
core   +1 more source

Mycobacterium tuberculosis: The Mechanism of Pathogenicity, Immune Responses, and Diagnostic Challenges

Journal of Clinical Laboratory Analysis, Volume 38, Issue 23, December 2024.
Mycobacterium tuberculosis acts as the causative agent of human tuberculosis and is regarded as one of the most adaptable human pathogens. M. tuberculosis possesses several virulence factors that help the bacterium evade mucous barriers. The infection caused by M.
Noura Mohammadnabi, Jebreil Shamseddin, Mobina Emadi, Ali Bayat Bodaghi, Mahdieh Varseh, Aref Shariati, Mina Rezaei, Mahsa Dastranj, Abbas Farahani   +8 more
wiley   +1 more source

Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes. [PDF]

, 1988
Analyses of TCR-bearing murine and human T cells have defined a unique subpopulation of T cells that express the TCR-gamma/delta proteins. The specificity of TCR-gamma/delta T cells and their role in the immune response have not yet been elucidated. Here
Bluestone, JA, Cotterman, M, Cron, RQ, Houlden, BA, Matis, LA   +4 more
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Pan‐Cancer Analysis of Ezrin: A Comprehensive Examination of Its Prognostic Value and Immunological Implications

Organ Medicine, Volume 1, Issue 2, Page 70-84, December 2024.
This article comprehensively analyzes the pivotal role of ezrin, an ERM protein family member, in diverse tumor types, highlighting its immunomodulatory capabilities and associations with tumor progression, immune cell infiltration, and therapeutic responses.
Ruiqi Chen, Hongbiao Xu, Elfira Jurat, Hewang Huang, Shangwu Yang, Liang Han, Fengyun Wang   +6 more
wiley   +1 more source

Evans Medicine [PDF]

, 1990
Newsletter of the Evans Memorial Department of Clinical Research and Preventive Medicine at University ...
University Hospital, Evans Memorial Department of Clinical Research and Preventive Medicine
core  

Interactions of asbestos-activated macrophages with an experimental fibrosarcoma [PDF]

, 1983
Supernatants from in vivo asbestos-activated macrophages failed to show any cytostatic activity against a syngeneic fibrosarcoma cell line in vitro. UICC chrysotile-induced peritoneal exudate cells also failed to demonstrate any growth inhibitory effect ...
A Ewing, Ames B. N., Cohn Z. A., Davies P., Gabizon A., J M Davis, K Donaldson, K James, Keller R, Lowry 0., Pylev L. N., Raz A., Topping D. C.   +12 more
core   +2 more sources

Upscaling Osteoclast Generation by Enhancing Macrophage Aggregation Using Hollow Microgels

Small, Volume 20, Issue 46, November 14, 2024.
This study investigates the potential of high‐throughput droplet microfluidics for microencapsulation of human macrophages in hollow, sacrificial tyramine‐conjugated dextran microgels to facilitate osteoclast formation. Intriguingly, osteoclast formation within these 3D microenvironments is occurring at a significantly higher level compared to the ...
Johanna F.A. Husch, Nuno Araújo‐Gomes, Niels G.A. Willemen, Carla Cofiño‐Fabrés, Nils van Creij, Robert Passier, Jeroen Leijten, Jeroen J. J. P. van den Beucken   +7 more
wiley   +1 more source

Targeting CD25+ lymphoma cells with the antibody–drug conjugate camidanlumab tesirine as a single agent or in combination with targeted agents

British Journal of Haematology, Volume 205, Issue 5, Page 1873-1882, November 2024.
Camidanlumab tesirine is a CD25‐specific antibody‐drug conjugate employing SG3199, a highly cytotoxic DNA minor groove cross‐linking pyrrolobenzodiazepine dimer, with cytotoxic activity in lymphoma cells. The addition of other drugs targeting additional pathways can synergize with camidanlumab tesirine. Created with Biorende.
Filippo Spriano, Chiara Tarantelli, Luciano Cascione, Eugenio Gaudio, Gaetanina Golino, Lorenzo Scalise, Maria Teresa Cacciapuoti, Emanuele Zucca, Anastasios Stathis, Patrick H. Van Berkel, Giorgio Inghirami, Francesca Zammarchi, Francesco Bertoni   +12 more
wiley   +1 more source