Results 191 to 200 of about 36,827 (260)

Impact of Co‐Morbid Immunocompromise in HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

open access: yesThe Laryngoscope, Volume 136, Issue 10, Page 4279-4289, October 2026.
Among patients with surgically resected Human Papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC), immunocompromised patients had significantly worse overall survival compared to the non‐compromised group; however, these exploratory findings should be interpreted cautiously.
Maxwell L. Weng   +7 more
wiley   +1 more source

Risk‐Stratified Bilateral Tonsillectomy for Unilateral HPV‐Associated Tonsillar SCC: Oncologic and Functional Outcomes From a Single Institution

open access: yesLaryngoscope Investigative Otolaryngology, Volume 11, Issue 5, October 2026.
The role of contralateral tonsillectomy in unilateral HPV+ tonsillar squamous cell carcinoma (TSCC) is debated. Among 163 patients with p16‐positive TSCC, occult synchronous contralateral second primary malignancies clustered among patients with high‐risk preoperative features (20.0%) compared with low‐risk patients (6.7%, number needed to treat 14 ...
Tereza Vitkovska   +8 more
wiley   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta   +2 more
wiley   +1 more source

Environmental Asbestos Exposure as a Possible Pathway to Early‐Onset Pleural Mesothelioma: A Case From Afghanistan and Pakistan to London

open access: yesRespirology Case Reports, Volume 14, Issue 10, October 2026.
We report a case of a 40‐year‐old male with malignant pleural mesothelioma with no prior occupational exposure to asbestos. Environmental exposure as a cause of MPM may come into focus through migration from high environmental asbestos exposure regions in patients with no known occupational exposure.
Sophie Mounouchos   +5 more
wiley   +1 more source

Incidence of Gonadal and Extragonadal Germ Cell Tumours in Patients With Klinefelter Syndrome

open access: yesAndrology, Volume 14, Issue 7, Page 2274-2279, October 2026.
ABSTRACT Background Klinefelter's syndrome (KS; 47, XXY) is associated with an altered risk profile for malignancies compared with non‐KS males. In particular, several reports have noted a striking association between KS and extragonadal germ cell tumours (EGCTs), especially in the mediastinum, whereas the risk of testicular germ cell tumours (TGCTs ...
Aksh Tailor   +6 more
wiley   +1 more source

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