Results 51 to 60 of about 141,580 (256)

Penetrance of colorectal cancer among / carriers participating in the colorectal cancer familial registry in Ontario [PDF]

, 2009
Background Several DNA mismatch repair (MMR) genes, responsible for the majority of Lynch Syndrome cancers, have been identified, predominantly MLH1 and MSH2, but the risk associated with these mutations is still not well established. The
Yun-Hee Choi, Michelle Cotterchio, Gail McKeown-Eyssen, Monga Neerav, Bharati Bapat, Kevin Boyd, Steven Gallinger, John McLaughlin, Melyssa Aronson, Laurent Briollais, HT Lynch, T Bocker, M Aarnio, KM Lin, HFA Vasen, MG Dunlop, M Cotterchio, MG Dunlop, MO Woods, EL Kaplan, CR Boland, BV Bapat, JP Schouten, V Ramensky, PC Ng, P Kraft, YH Choi, MA Jenkins, K Lange, F Quehenberger, J Green, M Aarnio, NJ Froggart, HFA Vasen, Y Parc, H Hampel, HFA Vasen, CB Begg, J Carayol, B Theis   +39 more
core   +2 more sources

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients

Clinical and Developmental Immunology, 2010
High levels of microsatellite instability (MSI-high) are a cardinal feature of colorectal tumors from patients with Lynch Syndrome. Other key characteristics of Lynch Syndrome are that these patients experience fewer metastases and have enhanced survival
Kristen M. Drescher, Poonam Sharma, Henry T. Lynch   +2 more
doaj   +1 more source

Colorectal Carcinoma in a Young Male Diagnosed as Lynch Syndrome with a Rare PMS2 Pathogenic Germline Variant: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Colorectal cancers in young people can be due to inherited mutations in 5-10% of cases, among which Lynch syndrome is the most common. Lynch syndrome is defined as a genetic susceptibility to various types of cancer, with non polyposis colorectal cancer ...
Vijayashree S Gokhale, Vineetha Naga Lakshmi Giduturi, Mahabir Prasad Mishra, Mayur Ambekar, Dnyanada Shrirang Gokhale-Agashe   +4 more
doaj   +1 more source

Room for improvement: One third of Lynch syndrome patients presenting for genetic testing in a highly specialised centre in Stockholm already have cancer

Hereditary Cancer in Clinical Practice, 2021
Background Lynch syndrome is caused by germline mutations in the mismatch repair genes and is characterised by a familial accumulation of colorectal and other cancers.
Sophie Walton Bernstedt, Jan Björk, Kaisa Fritzell, Allan D. Spigelman, Erik Björck, Ann-Sofie Backman   +5 more
doaj   +1 more source

Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22 [PDF]

, 2012
A substantial proportion of familial colorectal cancer (CRC) is not a consequence of known susceptibility loci, such as mismatch repair (MMR) genes, supporting the existence of additional loci.
Allyson S Templeton, Brenda Diergaarde, Brooke L Fridley, Colon CFR, D Timothy Bishop, Daniel Buchanan, Daniel J Serie, Duncan C Thomas, Ellen L Goode, Finlay A Macrae, Fredrick Schumacher, Graeme P Young, Graham Casey, H Banfield Younghusband, Ingrid Winship, Jane S Green, Joanne P Young, John D Potter, John L Hopper, Julie M Cunningham, Loic Le Marchand, Mark A Jenkins, Melissa S DeRycke, Mine S Cicek, Noralane M Lindor, Polly A Newcomb, Robert W Haile, Roger C Green, Stephen N Thibodeau, Steven Gallinger, Susan Parry, Theodore G Krontiris, William R Bamlet, Zhu Chen   +33 more
core   +6 more sources

Monocyte maturation pattern by flow cytometry expression of CD64, CD300e, and CD14 correlates to presence of myeloid neoplasm and helps identify blast equivalents in the setting of monocytic neoplasm

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract CD300e is a marker of mature monocytes in flow cytometry; however, there is limited detailed information on staining patterns in conjunction with other monocyte markers. We evaluated the flow cytometric staining patterns of CD64, CD14, and CD300e in 12 negative and 33 positive peripheral blood specimens and 16 negative and 56 positive bone ...
Jenny Zhang, Jacob Kaplan, Elizabeth Courville   +2 more
wiley   +1 more source

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

Attitudes Toward Updated Genetic Testing Among Patients with Unexplained Mismatch Repair Deficiency [PDF]

, 2018
Individuals who have colorectal cancer (CRC) or endometrial cancer (EC) displaying loss of immunohistochemical (IHC) staining of one or more mismatch repair (MMR) proteins without a causative germline mutation are said to have unexplained mismatch repair
Omark, Jessica
core   +1 more source

Deficient mismatch repair: Read all about it (Review) [PDF]

, 2015
Defects in the DNA mismatch repair (MMR) proteins, result in a phenotype called microsatellite instability (MSI), occurring in up to 15% of sporadic colorectal cancers.
Adackapara, Alvino, Alvino, An, An, André, Bao, Bapat, Beamer, Beghelli, Begum, Bellcross, Bertagnolli, Birindelli, Boland, Bonadona, Bouzourene, Braun, Capper, Capper, Castiglia, Catasús, Chew, Chew, Cicek, Cohn, Colomba, Cravo, Crucianelli, Cunningham, Cunningham, Des Guetz, Diaz-Padilla, Elsaleh, Elsaleh, Engel, Ercoli, Fadhil, Falchetti, Fang, Fearon, Gazzoli, Genuardi, Graham, Graham, Gras, Guastadisegni, Halford, Hitchins, Hong, Hussein, Hussein, Hutchins, Huth, Ihle, Jasperson, Jass, Jensen, Kane, Kato, Kim, Kim, Kim, Kloor, Koopman, Korabiowska, Ladabaum, Lee, Ligtenberg, Liu, Loes, Loughrey, Lynch, Malesci, Marcelis, Matthews, McGivern, Mensenkamp, Murphy, Musulen, Mvundura, Müller, Nelson, Nilbert, Oki, Pal, Palmieri, Palmieri, Perez, Peris, Pineda, Plazzer, Poynter, Pritchard, Quinn, Resnick, Ribic, Richetta, Richetta, Ringelhan, Rodriguez-Bigas, Roth, Ruiz, Sargent, Scartozzi, Schneider, Schofield, Schofield, Sie, Sinicrope, Snowsill, Snowsill, SUSAN RICHMAN, Talwalkar, Terada, Thibodeau, Tikidzhieva, Tomiak, Tomlinson, Tomlinson, Umar, Vasen, Vasen, Venderbosch, Wang, Ward, Watson, Xiao, Xicola, Yan, Zaanan, Zhai   +131 more
core   +1 more source