Results 71 to 80 of about 141,580 (256)

Living at genetic risk: The patient experience of Lynch syndrome

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents, Georgina Hoffmann, Kelly Kohut   +2 more
wiley   +1 more source

Diagnosis of Lynch Syndrome-associated Prostatic Small Cell Neuroendocrine Carcinoma: A Clinical Case Analysis

CT Lilun yu yingyong yanjiu
Lynch syndrome is an autosomal dominant hereditary cancer syndrome characterized by germline mutations in DNA mismatch repair genes. Lynch syndrome-associated small cell neuroendocrine carcinoma of the prostate is an extremely rare extracolonic tumor ...
Heshi LIU, Yong CHEN, Xinran WANG, Xiaofeng QI   +3 more
doaj   +1 more source

Molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome)

Revista de la Facultad de Medicina, 2016
Lynch syndrome is the most common cause of inherited colorectal cancer, totaling 5 to 8% of all the cases with high susceptibility to this type of cancer and extracolonic cancer.
David Serrano, Clara Eugenia Arteaga
doaj   +1 more source

GENETIC COUNSELOR UTILIZATION AND INTERPRETATION OF SOMATIC TUMOR TESTING IN EVALUATION FOR LYNCH SYNDROME [PDF]

, 2019
Lynch syndrome (LS) is a hereditary cancer predisposition syndrome characterized by increased risk for colorectal and uterine cancers. Individuals with pathogenic variants in the mismatch repair (MMR) genes (MLH1, MSH2/EPCAM, MSH6, PMS2) are diagnosed ...
Williams, Danielle
core   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

CHARACTERISTICS OF INDIVIDUALS UNDERGOING PANEL GENETIC TESTING FOR PRIMARY BRAIN TUMORS [PDF]

, 2018
Background. Currently, there are no genetic testing guidelines for patients with a primary brain tumor (PBT). This population is largely understudied in terms of the family history, tumor grade, pathology, and their relation to genetic contribution.
Azam, Sarah
core   +1 more source

Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average‐Risk Populations, and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome and is characterized by an accelerated adenoma‐carcinoma sequence, a relatively higher prevalence of flat and subtle CRC precursor lesions, and exceptionally high adenoma miss rates despite intensive colonoscopy surveillance.
Robert Hüneburg, Querijn N. E. van Bokhorst, Evelien Dekker, Jacob Nattermann   +3 more
wiley   +1 more source

A DNA methylation assay (MPap) using self‐collected tampon versus cytology collection swab for endometrial cancer detection

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate the practicability of self‐collected tampons with the MPap assay for endometrial cancer (EC) detection, by comparing with the results of cervical swabs. Methods A total of 85 women at Tri‐Service General Hospital (TSGH) were included to directly compare the performance of physician‐collected swabs and self‐collected ...
Kuo‐Min Su, Kuo‐Chang Wen, Yi‐Hsin Lin, Po‐Hsuan Su, Lin‐Yu Chen, Hung Cheng Lai   +5 more
wiley   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Liver transplantation for arteriohepatic dysplasia (Alagille's syndrome) [PDF]

, 1992
Thirteen out of 268 children (
Borland, L, Carone, E, ChapChap, P, Esquivel, CO, Marino, IR, Rowe, MI, Starzl, TE, Todo, S, Tzakis, AG, Zetti, G   +9 more
core   +1 more source