Results 61 to 70 of about 1,289,326 (214)

Upper Gastrointestinal Cancer Surveillance in Lynch Syndrome

, 2022
Lynch syndrome is a common hereditary cancer predisposition syndrome associated with increased digestive cancer risk including colorectal, gastric, and duodenal cancers. While colorectal cancer surveillance is widely accepted to be an important part of a
Burke, Carol A., Bryson W. Katona, Shria Kumar, Carol A. Burke, Farha, Natalie, Natalie Farha, Kumar, Shria, Katona, Bryson W.   +7 more
core   +1 more source

Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient management

BMJ Open Quality
Lynch syndrome is associated with an increased risk of cancer, including endometrial cancer. We audited the introduction of a nurse-led testing and management pathway for Lynch syndrome.
Jo Morrison, Mohamed Shawky, Maria Murrey   +2 more
doaj   +1 more source

Clinical and genetic features of pediatric hereditary polyposis syndromes in Israel: A nationwide multicenter cohort

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Hereditary polyposis syndromes in children are rare, heterogeneous disorders associated with significant morbidity and long‐term risk of malignancy. Current data on their presentation, management, and outcomes in pediatric populations remain limited.
Shlomi Cohen, Tal Cozacov, Ilana Weintraub, Ron Shaoul, Oren Ledder, Dotan Yogev, Mordechai Slae, Ranya Egbarieh, Galina Ling, Anat Yerushalmy‐Feler   +9 more
wiley   +1 more source

How does genetic risk information for Lynch syndrome translate to risk management behaviours? [PDF]

, 2017
Background There is limited research on why some individuals who have undergone predictive genetic testing for Lynch syndrome do not adhere to screening recommendations.
Keogh, L, Flander, L, Gaff, Clara, Robbins, A, Jenkins, M, Steel, Emma, Flander, Louisa, Steel, E, Keogh, Louise, Gaff, C, Robbins, Andrew, Jenkins, Mark   +11 more
core   +1 more source

Clinical Benefit of Pembrolizumab in Lynch Syndrome-Associated Advanced Ovarian Cancer With Germline <i>MSH6</i> Variant: A Case Report. [PDF]

Clin Case Rep
ABSTRACT This case highlights the importance of genetic evaluation during treatment in young patients with advanced ovarian cancer. Lynch syndrome caused by a germline MSH6 pathogenic variant was diagnosed during first‐line maintenance therapy, and pembrolizumab achieved a durable response in recurrent disease.
Yokozawa T, Nakagawa S, Suzuki Y, Tokinaga-Uchiyama A, Konnai K, Narimatsu H, Hiroshima Y, Saji H.   +7 more
europepmc   +2 more sources

Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review

Movement Disorders, EarlyView.
Abstract Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.
Dorota Sarwinska, Maresa Buchholz, Audrey Iskandar, Marcus Grobe‐Einsler, Thomas Klockgether, Jennifer Faber, Bernhard Michalowsky   +6 more
wiley   +1 more source

Lynch Syndrome: Clinical Approach

, 2010
About 2-3% of colorectal cancer occurs in the context of Lynch syndrome, which is due to germline mutations in one allele of mismatch repair genes.
Carvalho, Giselda, Campos, Sara, Dias, Margarida   +2 more
core  

Lynch Syndrome [PDF]

, 2018
Lynch syndrome (LS) was previously known as Hereditary Non-polyposis colorectal cancer syndrome (HNPCC) (Shulman, 2015) is a hereditary cancer syndrome. The research explored Lynch Syndrome, the identification, and treatment. Lynch syndrome is associated
Nutter, Raejeanne B.
core  

Calibration‐Free Estimation of Cerebrovascular Reactivity From Resting‐State BOLD fMRI Using Reconstructed Respiratory Fluctuations

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Cerebrovascular reactivity (CVR) provides an important index of vascular health and is conventionally quantified using a hypercapnic gas or breath‐hold challenge in conjunction with blood‐oxygen‐level‐dependent functional magnetic resonance imaging (BOLD‐fMRI).
Abdoljalil Addeh, Ethan Church, Muhammad Mahajna, Karen Ardila, Pattarawut Charatpangoon, Alexander D. Cohen, Yang Wang, Rebecca J. Williams, G. Bruce Pike, M. Ethan MacDonald   +9 more
wiley   +1 more source

Efficacy and Safety of Cannabis Derivates and Their Synthetic Analogs. Overview of Systematic Reviews

Phytotherapy Research, EarlyView.
ABSTRACT The use of medicinal products derived from cannabis and its synthetic analogues has grown in recent years for various health conditions, which led to an increase in systematic reviews (SR) on the topic. The objective of this overview was to identify, synthesize, and critically appraise the evidence from SR on the benefits and harms of cannabis
Rafael Leite Pacheco, Daniela Fortunato Rêgo, Carolina de Oliveira Cruz Latorraca, Marco Aurelio de Carvalho Nascimento, André Bastos Daher, Rachel Riera   +5 more
wiley   +1 more source