Results 61 to 70 of about 31,569 (215)

Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient management

BMJ Open Quality
Lynch syndrome is associated with an increased risk of cancer, including endometrial cancer. We audited the introduction of a nurse-led testing and management pathway for Lynch syndrome.
Jo Morrison, Mohamed Shawky, Maria Murrey   +2 more
doaj   +1 more source

Calibration‐Free Estimation of Cerebrovascular Reactivity From Resting‐State BOLD fMRI Using Reconstructed Respiratory Fluctuations

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Cerebrovascular reactivity (CVR) provides an important index of vascular health and is conventionally quantified using a hypercapnic gas or breath‐hold challenge in conjunction with blood‐oxygen‐level‐dependent functional magnetic resonance imaging (BOLD‐fMRI).
Abdoljalil Addeh, Ethan Church, Muhammad Mahajna, Karen Ardila, Pattarawut Charatpangoon, Alexander D. Cohen, Yang Wang, Rebecca J. Williams, G. Bruce Pike, M. Ethan MacDonald   +9 more
wiley   +1 more source

Hereditary Nonpolyposis Colon Cancer (Lynch Syndrome): An Emerging Public Health Concern

Health Science Reports
Background Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes that confer increased lifetime risks for colorectal, endometrial,
Md Mohiuddin
doaj   +1 more source

Squamous Cell Carcinoma of the Lung With Microsatellite Instability in a Patient With Lynch Syndrome: A Case Report

JTO Clinical and Research Reports
Lynch syndrome is the most common autosomal dominant inherited cancer predisposing syndrome, due to mutations in DNA mismatch repair genes. The key feature of cancers in Lynch syndrome is microsatellite instability and a high risk of developing mainly ...
Emna Haddad, MD, Benjamin Bottet, MD, Pierre-Alain Thiebaut, MD, PhD, Samira Morin, MD, Hélène Dreyfus, MD, Élise Vannier, MD, Colette Vincent, MD, Florent Marguet, MD, PhD, Aude Lamy, PhD, Hagay Sobol, MD, PhD, Jean-Marc Baste, MD, PhD, Florian Guisier, MD, PhD, Jean-Christophe Sabourin, MD, PhD, Nicolas Piton, MD, PhD   +13 more
doaj   +1 more source

Distinct Symptom Occurrence Subgroups Among Patients With Colorectal Cancer: Differences in Social Determinants of Health and Diet Quality

Research in Nursing &Health, EarlyView.
ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer mortality in the United States. Many patients with CRC experience physical and psychological symptoms that diminish quality of life and are shaped by social determinants of health (SDOH) and diet quality.
Youran Lee, Qing Yang, Melissa Kay, Donald E. Bailey, Biljana Gigic, Sheetal Hardikar, Adetunji T. Toriola, David Shibata, Christopher I. Li, Doratha A. Byrd, Jane C. Figueiredo, Ildiko Strehli, Megan Mclaws, Vaia Florou, Mmadili Ilozumba, Patricia Erickson, Apurva Medhe, Cornelia M. Ulrich, Rosa M. Gonzalez‐Guarda   +18 more
wiley   +1 more source

Diagnóstico y comportamiento clínico de pacientes con sospecha de síndrome de Lynch sin mutación conocida

Revista de Gastroenterología de México, 2018
Resumen: Introducción y objetivos: La sospecha de síndrome de Lynch sin mutación conocida (SSL) se diagnostica cuando existe déficit de expresión de las proteínas reparadoras de ADN pero con estudio genético normal.
L. Adán-Merino, M. Aldeguer-Martínez, E. Alonso-Gamarra, F. Valentín-Gómez, C. Zaera-De la Fuente, S. Martín-Chávarri   +5 more
doaj   +1 more source

Lynch Syndrome [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
Lynch syndrome (LS) is an autosomal-dominant disease characterized by an increased cancer susceptibility, particularly of the colon and endometrium. LS is caused by a constitutional heterozygous loss-of-function mutation or epimutation in one of the DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6 or PMS2).
openaire   +2 more sources

Efficacy and Safety of Cannabis Derivates and Their Synthetic Analogs. Overview of Systematic Reviews

Phytotherapy Research, EarlyView.
ABSTRACT The use of medicinal products derived from cannabis and its synthetic analogues has grown in recent years for various health conditions, which led to an increase in systematic reviews (SR) on the topic. The objective of this overview was to identify, synthesize, and critically appraise the evidence from SR on the benefits and harms of cannabis
Rafael Leite Pacheco, Daniela Fortunato Rêgo, Carolina de Oliveira Cruz Latorraca, Marco Aurelio de Carvalho Nascimento, André Bastos Daher, Rachel Riera   +5 more
wiley   +1 more source

Diagnosis and clinical behavior in patients with Lynch-like syndrome

Revista de Gastroenterología de México (English Edition), 2018
Introduction and aims: Lynch-like syndrome is diagnosed when there is an expression deficit in DNA mismatch repair proteins but a normal genetic study. The behavior and management of that pathology are currently a subject of debate. We present herein the
L. Adán-Merino, M. Aldeguer-Martínez, E. Alonso-Gamarra, F. Valentín-Gómez, C. Zaera-De la Fuente, S. Martín-Chávarri   +5 more
doaj   +1 more source

What Happens After Menopause (WHAM)? A Progress Report of a Prospective Controlled Study of Women After Pre‐Menopausal Risk‐Reducing Bilateral Salpingo‐Oophorectomy

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Surgical menopause, the removal of both ovaries prior to natural menopause, may impact short‐and long‐term physical and emotional health. An increasingly common cause of surgical menopause is risk‐reducing salpingo‐oophorectomy (RRSO) in those at high inherited risk of ovarian cancer.
Sarah A. L. Price, Pauline M. Maki, Samar R. El Khoudary, Alison Brand, Rakibul M. Islam, Susan M. Domchek, Hadine Joffe, Gita D. Mishra, Katrina M. Moss, Fiona C. Baker, Sabine Braat, John D. Wark, Martha Hickey   +12 more
wiley   +1 more source