Results 81 to 90 of about 31,569 (215)

Early Cervical and Orofacial Variable Dystonia in Levodopa‐Naïve PRKN Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Amy Gallagher, Aine Redmond, John McKinley, John Inocentes, Diana A Olszewska, Conor Fearon, Tim Lynch   +6 more
wiley   +1 more source

The ‘Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease’ (PATROL) study

BJU International, EarlyView.
Background Inherited (germline) pathogenic and likely pathogenic variants (gPVs) in key genes associated with increased risk of prostate cancer (PCa) now warrant more attentive PCa screening per National Comprehensive Cancer Network (NCCN) guidelines—e.g., BRCA2, HOXB13, ATM, BRCA1, MSH2, MSH6, CHEK2 and TP53.
Heather H. Cheng, Kara N. Maxwell, Keyan Salari, Matthew R. Cooperberg, Kristin Follmer, Joanne M. Jeter, Grace Jun, Daniel J. Lee, Hiten D. Patel, Edward M. Schaeffer, Alexandra O. Sokolova, Erika M. Wolff, Daniel W. Lin   +12 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

A Micro-Costing Study of Screening for Lynch Syndrome-Associated Pathogenic Variants in an Unselected Endometrial Cancer Population: Cheap as NGS Chips?

Frontiers in Oncology, 2019
Background: Lynch syndrome is the most common inherited cause of endometrial cancer. Identifying individuals affected by Lynch syndrome enables risk-reducing interventions including colorectal surveillance, and cascade testing of relatives.Methods: We ...
Neil A. J. Ryan, Neil A. J. Ryan, Niall J. Davison, Katherine Payne, Anne Cole, D. Gareth Evans, D. Gareth Evans, D. Gareth Evans, Emma J. Crosbie, Emma J. Crosbie, Emma J. Crosbie   +10 more
doaj   +1 more source

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Traditional serrated adenoma of the colorectum: Evolving concepts in histological classification and terminology

Histopathology, EarlyView.
The definition of the colorectal traditional serrated adenoma (TSA) has evolved to recognize a broader morphological spectrum, including classical, flat and mixed lesions reflecting early development and neoplastic progression. Updated WHO classification highlights the need for consistent terminology to improve recognition and to distinguish TSA from ...
Christophe Rosty, Maurice B. Loughrey, Taiki Hashimoto, Markus Mäkinen, Rish K. Pai, Shigeki Sekine, Rhonda K. Yantiss, Iris D. Nagtegaal   +7 more
wiley   +1 more source

MSH6 germline mutations leading to Lynch syndrome-associated cholangiocarcinoma: a case report

Frontiers in Oncology
Lynch syndrome, a hereditary cancer susceptibility syndrome, arises from pathogenic mutations in mismatch repair genes. This syndrome is strongly linked to colorectal and endometrial cancers, as well as an elevated risk for other cancers such as gastric,
Zheng Zhang, Subo Ma, Shixing Li, Zhengfu Chen, Runda Song, Zhanpeng Wang   +5 more
doaj   +1 more source

Avoidance habit learning after recovery from anorexia nervosa: An fMRI study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Anorexia Nervosa (AN) has been linked to altered self‐regulatory control processes and maladaptive habitual avoidance behavior. Both goal‐directed and habit systems may be relevant to AN, in which restrictive eating behavior can appear highly deliberate and increasingly automatic over time.
Clara M. Breier, Julius Hennig, Joseph A. King, Daniel Geisler, Arne Doose, Ilka Boehm, Maria Seidel, Tung Anh Nguyen, Katharina Zwosta, Veit Roessner, Uta Wolfensteller, Hannes Ruge, Stefan Ehrlich   +12 more
wiley   +1 more source

Expert‐Based Prioritization of Control Measures for Salmonid Rickettsial Septicemia in Chilean Salmon Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Piscirickettsiosis (SRS) remains the main infectious disease affecting salmon aquaculture in Chile. This study evaluated expert perceptions of the effectiveness of SRS control measures and the level of agreement among industry professionals.
Patricio Bustos, Benjamín Diethelm‐Varela, Andrés Riofrio, Marcos Mancilla, Fernando O. Mardones   +4 more
wiley   +1 more source

Self‐Directed Mikoto Simulator Training for Colonoscopy in Gastroenterology Trainees: An International Multicenter Randomized Trial

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Objectives Simulation‐based colonoscopy training may support early acquisition of insertion skills, but its clinical effect remains uncertain. We evaluated whether a self‐directed curriculum using the mikoto colonoscopy simulator improved insertion performance in gastroenterology trainees.
Daisuke Yamaguchi, Ryo Shimoda, Masashi Fujii, Tomohiko Richard Ohya, Han‐Mo Chiu, Naoyuki Tominaga, Hidenori Hidaka, Hiroharu Kawakubo, Yosuke Minoda, Kosuke Maehara, Hiroko Fukuda, Takuma Okamura, Kiwamu Tanaka, Masakuni Kobayashi, Tetsuhito Muranaka, Shuichi Miyamoto, Mitsuru Esaki, Ayako Takamori, Yuichiro Ikebuchi, Taro Akashi, Naoyuki Yamaguchi, Masaru Ueki, Hajime Isomoto, Motohiro Esaki   +23 more
wiley   +1 more source