Results 101 to 110 of about 37,501 (261)

A Micro-Costing Study of Screening for Lynch Syndrome-Associated Pathogenic Variants in an Unselected Endometrial Cancer Population: Cheap as NGS Chips?

Frontiers in Oncology, 2019
Background: Lynch syndrome is the most common inherited cause of endometrial cancer. Identifying individuals affected by Lynch syndrome enables risk-reducing interventions including colorectal surveillance, and cascade testing of relatives.Methods: We ...
Neil A. J. Ryan, Neil A. J. Ryan, Niall J. Davison, Katherine Payne, Anne Cole, D. Gareth Evans, D. Gareth Evans, D. Gareth Evans, Emma J. Crosbie, Emma J. Crosbie, Emma J. Crosbie   +10 more
doaj   +1 more source

C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins

, 2012
The human DNA mismatch repair (MMR) process is crucial to maintain the integrity of the genome and requires many different proteins which interact perfectly and coordinated.
Hinrichsen, Inga Malena, Stefan Zeuzem, Hinrichsen Inga, Sandra Passmann, Plotz Guido, Adam, Ronja Sophia Mercedes, Plotz, Guido, Zeuzem Stefan, Guido Plotz, Passmann, Sandra, Angela Brieger, Ronja Adam, Brieger, Angela, Inga Hinrichsen, Brieger Angela, Passmann Sandra, Adam Ronja, Zeuzem, Stefan   +17 more
core   +1 more source

Neurodiversity and intersectionality in the workplace: A narrative review and research agenda

International Journal of Management Reviews, EarlyView.
Abstract Neurodiversity has important implications for individuals and organizations as an increasingly salient but under‐researched dimension of diversity in the workplace. In this article, we provide an interdisciplinary review of neurodiversity research through the lens of intersectionality, with a particular focus on the potential ways ...
Thomas Calvard, Debora Gottardello, Ji‐Won Song   +2 more
wiley   +1 more source

Geriatric Models of Surgical Care: A Scoping Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To synthesise literature on hospital‐based geriatric models of care for older adults undergoing surgery, examining structures, team composition, governance and nursing contributions. Design Scoping review. Methods Following JBI methodology, two reviewers independently screened articles against eligibility criteria (Population: adults ≥ 65 ...
Sarah Hughes, Ut Bui, Clint Douglas, Andrea Taylor   +3 more
wiley   +1 more source

MSH6 germline mutations leading to Lynch syndrome-associated cholangiocarcinoma: a case report

Frontiers in Oncology
Lynch syndrome, a hereditary cancer susceptibility syndrome, arises from pathogenic mutations in mismatch repair genes. This syndrome is strongly linked to colorectal and endometrial cancers, as well as an elevated risk for other cancers such as gastric,
Zheng Zhang, Subo Ma, Shixing Li, Zhengfu Chen, Runda Song, Zhanpeng Wang   +5 more
doaj   +1 more source

Lynch Syndrome II in a Navajo Family: A Revisit [PDF]

, 1992
A study of variation in cancer incidence among the Navajo Indians, given their relative racial and environmental homogeneity, could provide important clues to etiology and, ultimately, to cancer control.
Lynch, Patrick, Drouhard, Thomas, Lynch, Henry T., Lynch, Jane F., Lanspa, Stephen J., Bronson, Earlene   +5 more
core  

Update on the clinical management of Lynch syndrome

, 2013
6323 ...
Lynch, H. T., Lynch, P. M., Henry T. Lynch, Patrick M. Lynch   +3 more
core   +1 more source

Etymology and entomology: The semiotics and ethics of multispecies gene nomenclatures

Journal of Linguistic Anthropology, Volume 36, Issue 2, August 2026.
Abstract This article examines controversies surrounding gene names that are perceived as humorous in the context of fruit flies but are considered rude in the clinical context of human medicine. Drawing on ethnographic fieldwork in insect laboratories, interviews with entomologists and geneticists, and an analysis of scientific and clinical ...
Colin M. E. Halverson
wiley   +1 more source

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

Physical Activity and Metabolic Alterations in Children and Adolescents Across Different Weight Groups: A Systematic Review

European Journal of Sport Science, Volume 26, Issue 7, July 2026.
ABSTRACT Inadequate physical activity (PA) and increased sedentary time are key drivers of cardiometabolic disorders related to being overweight, and metabolomics offers a promising novel approach to study their associations. The aim of this systematic review was to assess the evidence on metabolites associated with PA and/or sedentary time among ...
Marja H. Leppänen, Jukka E. Hintikka, Kathleen Wijnant, Eero A. Haapala, Timo A. Lakka, Lynn Vanhaecke, Heli Viljakainen   +6 more
wiley   +1 more source