A Major Facilitator Superfamily Transporter Contributes to Ergot Alkaloid Accumulation but Not Secretion in Aspergillus leporis [PDF]
Applied MicrobiologyErgot alkaloids are fungal natural products with important roles in agriculture and medicine. We used heterologous expression and gene knockout approaches to investigate potential roles for the product of a major facilitator superfamily transporter gene (
Abigail M. Jones +2 more
doaj +3 more sources
Derivation of the multiply‐branched ergot alkaloid pathway of fungi [PDF]
Microbial Biotechnology, Volume 16, Issue 4, Page 742-756, April 2023., 2023 Ergot alkaloids are a large family of fungal specialized metabolites that are important as toxins in agriculture and as the foundation of powerful pharmaceuticals. Fungi from several lineages and diverse ecological niches produce ergot alkaloids from at least one of several branches of the ergot alkaloid pathway.
Daniel G. Panaccione
wiley +2 more sources
Methods of Lysergic Acid Synthesis-The Key Ergot Alkaloid. [PDF]
Molecules, 2022 Ergot is the spore form of the fungus Claviceps purpurea. Ergot alkaloids are indole compounds that are biosynthetically derived from L-tryptophan and represent the largest group of fungal nitrogen metabolites found in nature.
Jastrzębski MK, Kaczor AA, Wróbel TM.
europepmc +2 more sources
Biochemical and Genetic Characterization of Ergot Alkaloid Biosynthesis in Aspergillus aspearensis [PDF]
ToxinsErgot alkaloids derived from lysergic acid have impacted humankind significantly as toxins in agriculture and as the foundations of several pharmaceuticals.
Jessica L. Fuss, Daniel G. Panaccione
doaj +2 more sources
Ergot Alkaloids Affect Foraging Activity of the Slime Mold Physarum polycephalum [PDF]
ToxinsWe tested whether ergot alkaloids would affect the interaction of a protist with an ergot alkaloid-producing fungus by studying the response of the plasmodial slime mold Physarum polycephalum to cultures of Aspergillus leporis.
Jordan R. Sexstone +2 more
doaj +2 more sources
Metabolomic shifts in beef steers rotationally grazing toxic endophyte-infected tall fescue under fall conditions [PDF]
Frontiers in Veterinary ScienceBackgroundFescue toxicosis (FT) results from ingestion of tall fescue infected with the ergot alkaloid (EA)-producing endophyte Epichloë coenophiala. While the vascular system is a major EA target, their biogenic amine-like properties can trigger wider ...
Ignacio M. Llada +11 more
doaj +2 more sources
Monitoring and Managing of Ergot Alkaloids in Cereal Grains: A Comprehensive Analysis of Analytical Challenges, Sampling Uncertainty, and Processing for Food Safety [PDF]
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.ABSTRACT Ergot alkaloids (EAs), toxic secondary metabolites produced by Claviceps purpurea, pose food and feed safety concerns for cereal grains, particularly rye and wheat. While EAs are most frequently associated with rye, their occurrence in other cereals has been increasingly reported across diverse regions.
Chamali Kodikara +2 more
wiley +2 more sources
Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives [PDF]
Advanced Science, Volume 12, Issue 15, April 17, 2025.Graphic illustration showing the strategic approaches based on the currently investigated evidence of psychedelics that suggests the challenges and how to address the prescription of mental disorders. These applicable avenues may provide substantial insight into distinguishing between brain networks and psychedelics.
Sung‐Hyun Kim +5 more
wiley +2 more sources
A Concise and Malleable Synthesis of (±)-Lysergic Acid [PDF]
, 2022 This Letter describes a concise synthesis of lysergic acid from simple aromatic precursors. The successful strategy relies on the coupling, dearomatization, and cyclization of a halopyridine with a 4-haloindole derivative in 6 total synthetic steps from ...
Ryan, Harbit, Brian, Knight, Joel, Smith
core +2 more sources
Reaction Mechanism of 2-Amido-2-Aminoacetic Acid-Formation from Amides and 2-Iminoacetic Acid: A DFT-study and Wavefunction Analysis [PDF]
, 2021 Based on a study of Wei Zeng et. al.[7], where the synthesis of gem-diamino acid esters from 2-iminoacetic acid esters and amides, with various N- and C-substituents, respectively, is reported, a modeled reaction, where the latter substituents were ...
Georg, Dazinger
core +1 more source