Methods of Lysergic Acid Synthesis—The Key Ergot Alkaloid [PDF]
Molecules, 2022 Ergot is the spore form of the fungus Claviceps purpurea. Ergot alkaloids are indole compounds that are biosynthetically derived from L-tryptophan and represent the largest group of fungal nitrogen metabolites found in nature.
Michał K. Jastrzębski +2 more
doaj +5 more sources
Construction of an efficient Claviceps paspali cell factory for lysergic acid production [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 Lysergic acid (LA) is the key precursor of ergot alkaloids, and its derivatives have been used extensively for the treatment of neurological disorders. However, the poor fermentation efficiency limited its industrial application.
Mingzhe Hu +30 more
doaj +4 more sources
Increasing lysergic acid levels for ergot alkaloid biosynthesis: Directing catalysis via the F-G loop of Clavine oxidases [PDF]
Frontiers in Microbiology, 2023 Most ergot alkaloid drugs are semi-synthetically derived from the natural product lysergic acid, a valuable precursor for the development of novel ergot alkaloid drugs.
Li Rong Lim +13 more
doaj +4 more sources
Contribution of a novel gene to lysergic acid amide synthesis in Metarhizium brunneum [PDF]
BMC Research Notes, 2022 Objective The fungus Metarhizium brunneum produces ergot alkaloids of the lysergic acid amide class, most abundantly lysergic acid α-hydroxyethylamide (LAH). Genes for making ergot alkaloids are clustered in the genomes of producers. Gene clusters of LAH-
Kelcie N. Britton +4 more
doaj +2 more sources
Reconstituting the complete biosynthesis of D-lysergic acid in yeast [PDF]
Nature Communications, 2022 The ergot alkaloids are a class of natural products known for their pharmacologically privileged molecular structure that are used in the treatment of neurological ailments.
Garrett Wong +6 more
doaj +2 more sources
A single lysergyl peptide synthetase assembles lysergic acid amides in Aspergillus species. [PDF]
PLoS ONEThe agriculturally and pharmaceutically important lysergic acid amides ergonovine and lysergic acid α-hydroxyethylamide (LAH) are synthesized from a lysergyl-alanine precursor.
Samantha J Fabian +3 more
doaj +2 more sources
Clinical Research on Lysergic Acid Diethylamide (LSD) in Psychiatry and Neuroscience [PDF]
PharmaceuticalsLysergic acid diethylamide (LSD) is gaining renewed interest as a potential treatment for anxiety, depression, and alcohol use disorder, with clinical trials reporting significant symptom reductions and long-lasting effects.
Hossein Omidian, Alborz Omidian
doaj +2 more sources
Lysergic Acid Amide (LSA), an LSD Analog: Systematic Review of Pharmacological Effects, Adverse Outcomes, and Therapeutic Potentials [PDF]
PharmacyObjective: To systematically review the scientific literature on lysergic acid amide (LSA), focusing on its physical, neurobiological, and social effects, as well as its potential risks and therapeutic uses.
Paula S. C. C. Castro +7 more
doaj +2 more sources
Lysergic acid diethylamide-derived excitatory/inhibitory ratio change enhances global synchrony in functional brain dynamics. [PDF]
PLoS Computational BiologyLysergic acid diethylamide (LSD) has shown remarkable potential in modulating brain functional organization and dynamics. However, the exact mechanisms underlying its effects remain unclear.
Lingyu Zhang +9 more
doaj +2 more sources
Independent Evolution of a Lysergic Acid Amide in Aspergillus Species. [PDF]
Appl Environ Microbiol, 2021 Jones AM, Steen CR, Panaccione DG.
europepmc +2 more sources