Results 31 to 40 of about 13,713 (214)

Understanding the effects of lysergic acid diethylamide and the importance of its prevention

Health Sciences Review, 2023
This review is on lysergic acid diethylamide (LSD), which has a halogenic effect and is addictive. Up to now, LSD has been used for pleasure-inducing or spiritual purposes. Since it is soluble in water, it can be administered in different forms.
Burak Okumuş, Ahmet Metin, İ. Afşin Kariper   +2 more
doaj   +1 more source

Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans [PDF]

, 2016
Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the psychedelic 5-HT2A and sigma-1 agonist N,N-dimethyltryptamine (DMT) plus ß-carboline alkaloids with ...
Alonso, Joan Francesc, Antonijoan Arbós, Rosa Ma (Rosa María), Barker, Steven, Feilding, Amanda, Friedlander, Pablo, Maqueda, Ana Elda, Mañanas, Miquel Àngel, Rabella, Mireia, Riba, Jordi, Rodríguez-Pujadas, Aina, Romero, Sergio, Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia, Valle, Marta   +12 more
core   +3 more sources

Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775) [PDF]

, 2018
Lysergic acid diethylamide (LSD) is perhaps one of the best-known psychoactive substances and many structural modifications of this prototypical lysergamide have been investigated. Several lysergamides were recently encountered as “research chemicals” or
Abramson, Abramson, Araneda, Ashby, Babij, Blair, Brandt, Brandt, Brandt, Brandt, Canal, Chemel, Darmani, Darmani, Darmani, Dilly, Dursun, Forster, Fox, Gasser, Gerber, Gogerty, González-Maeso, Gudelsky, Halberstadt, Halberstadt, Halberstadt, Halberstadt, Halberstadt, Halberstadt, Heal, Hintzen, Hoffman, Hofmann, Isbell, Karst, Kim, Kleven, Kraehenmann, Krebs-Thomson, Li, Marona-Lewicka, Martel, Matsumoto, Nakahara, Newman-Tancredi, Nichols, Nichols, Nichols, Nichols, Pokorny, Preller, Rényi, Salmi, Schreiber, Serafine, Sheldrick, Sheldrick, Silva, Stoll, Strassman, Testa, Valle, Vetulani, Vickers, Vollenweider, Wacker, Watts   +67 more
core   +1 more source

Psilocybin sex-dependently reduces alcohol consumption in C57BL/6J mice

Frontiers in Pharmacology, 2023
The classical psychedelic psilocybin is of interest as a treatment for alcohol use disorder (AUD). This study investigated the effects of psilocybin on voluntary ethanol consumption in adult male and female C57BL/6J mice administered saline or psilocybin
Kenneth Alper, Kenneth Alper, Janelle Cange, Ria Sah, Deanna Schreiber-Gregory, Henry Sershen, Henry Sershen, K. Yaragudri Vinod, K. Yaragudri Vinod, K. Yaragudri Vinod   +9 more
doaj   +1 more source

Psychedelics Promote Structural and Functional Neural Plasticity. [PDF]

, 2018
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast ...
Barragan, Eden V, Burbach, Kyle F, Cameron, Lindsay P, Dennis, Megan Y, Duim, Whitney C, Gray, John A, Greb, Alexandra C, Ly, Calvin, McAllister, A Kimberley, Olson, David E, Ori-McKenney, Kassandra M, Paddy, Michael R, Soltanzadeh Zarandi, Sina, Sood, Alexander, Wilson, Paige C, Wong, Jonathan M   +15 more
core   +2 more sources

Acute effects of lysergic acid diethylamide (LSD) on resting brain function

Swiss Medical Weekly, 2019
Lysergic acid diethylamide (LSD) is a potent hallucinogenic substance that was extensively investigated by psychiatrists during the 1950s and 1960s.
Felix Müller, Stefan Borgwardt
doaj   +1 more source

Analysis of Ergot Alkaloids

Toxins, 2015
The principles and application of established and newer methods for the quantitative and semi-quantitative determination of ergot alkaloids in food, feed, plant materials and animal tissues are reviewed.
Colin Crews
doaj   +1 more source

A Major Facilitator Superfamily Transporter Contributes to Ergot Alkaloid Accumulation but Not Secretion in Aspergillus leporis

Applied Microbiology
Ergot alkaloids are fungal natural products with important roles in agriculture and medicine. We used heterologous expression and gene knockout approaches to investigate potential roles for the product of a major facilitator superfamily transporter gene (
Abigail M. Jones, Kyle A. Davis, Daniel G. Panaccione   +2 more
doaj   +1 more source

An open-label pilot trial assessing tolerability and feasibility of LSD microdosing in patients with major depressive disorder (LSDDEP1)

Pilot and Feasibility Studies, 2023
Background Globally, an estimated 260 million people suffer from depression [1], and there is a clear need for the development of new, alternative antidepressant therapies.
Carina Joy Donegan, Dimitri Daldegan-Bueno, Rachael Sumner, David Menkes, William Evans, Nicholas Hoeh, Frederick Sundram, Lisa Reynolds, Rhys Ponton, Alana Cavadino, Todd Smith, Partha Roop, Nathan Allen, Binu Abeysinghe, Darren Svirskis, Anna Forsyth, Mahima Bansal, Suresh Muthukumaraswamy   +17 more
doaj   +1 more source

A New Synthesis of Lysergic Acid [PDF]

Organic Letters, 2003
[reaction: see text] (+/-)-Lysergic acid has been synthesized via an economical 8-step route from 4-bromoindole and isocinchomeronic acid without the need to protect the indole during the synthesis. Initial efforts to form the simpler 3-acylindole derivatives first and then cyclize these were unsuccessful in the cyclization step.
James B, Hendrickson, Jian, Wang
openaire   +2 more sources