Results 21 to 30 of about 2,729,303 (155)
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source
Drug stability in forensic toxicology
WIREs Forensic Science, Volume 5, Issue 4, July/August 2023., 2023 The stability of analytes of interest in solvents and biological matrices depends on many factors, including time, storage conditions, pH, and temperature. It is essential for forensic toxicologists to understand sample preservation techniques and limitations, including analyte metabolism and degradation pathways, when interpreting antemortem and ...
Lorna A. Nisbet +2 more
wiley +1 more source
Pharmacokinetics and concentration-effect relationship of oral LSD in humans [PDF]
, 2015 BACKGROUND: The pharmacokinetics of oral lysergic acid diethylamide are unknown despite its common recreational use and renewed interest in its use in psychiatric research and practice.
Dolder, Patrick C. +9 more
core +1 more source
Are psychedelics the answer to chronic pain: A review of current literature
Pain Practice, Volume 23, Issue 4, Page 447-458, April 2023., 2023 Abstract Aims We aim to provide an evidence‐based overview of the use of psychedelics in chronic pain, specifically LSD and psilocybin. Content Chronic pain is a common and complex problem, with an unknown etiology. Psychedelics like lysergic acid diethylamide (LSD) and psilocybin, may play a role in the management of chronic pain.
Nina I. Kooijman +6 more
wiley +1 more source
Analytical profile of the lysergamide 1cP‐AL‐LAD and detection of impurities
Drug Testing and Analysis, Volume 15, Issue 3, Page 277-291, March 2023., 2023 An analytical profile of 1cP‐AL‐LAD using chromatographic, mass spectrometric and spectroscopic methods, and detection of 17 impurities based on analysis by LC‐QTOF‐MS/MS. Detections included AL‐LAD, 1P‐AL‐LAD, and other compounds, such as those potentially reflecting various oxidative changes that might have occurred during synthesis.
Pierce V. Kavanagh +8 more
wiley +1 more source
Journal of Chemistry, Volume 2023, Issue 1, 2023., 2023 Across communities worldwide, various new psychoactive substances (NPSs) continue to emerge, which worsens the challenges to global mental health, drug rules, and public health risks, as well as combats their usage. Specifically, the vast number of NPSs that are currently available, coupled with the rate at which new ones emerge worldwide, increasingly
Chinaza Godswill Awuchi +7 more
wiley +1 more source
Total Synthesis of Lysergic Acid
, 2016 A total synthesis of lysergic acid was accomplished. Key features of our synthesis include stereoselective construction of the stereogenic centers at the allylic positions by using the Evans aldol reaction, and a sequential process with a ring-closing ...
Tohru Fukuyama (1508317) +2 more
core +3 more sources
Enantioefficient Synthesis of α-Ergocryptine: First Direct Synthesis of (+)-Lysergic Acid
, 2016 The first direct synthesis of (+)-lysergic acid (2a) suitable for scale-up has been achieved by the following reaction sequence. Bromoketones 4d or 4g were allowed to react with amine 5 followed by deprotection, and the resulting diketone 6c was ...
István Moldvai (2640835) +5 more
core +4 more sources
Diversification of Ergot Alkaloids in Natural and Modified Fungi
Toxins, 2015 Several fungi in two different families––the Clavicipitaceae and the Trichocomaceae––produce different profiles of ergot alkaloids, many of which are important in agriculture and medicine.
Sarah L. Robinson, Daniel G. Panaccione
doaj +1 more source
Six-Step Synthesis of (±)-Lysergic Acid
, 2023 This article describes a concise synthesis of lysergic acid from simple aromatic precursors. The successful strategy relies on the coupling, dearomatization, and cyclization of a halopyridine with a 4-haloindole derivative in 6 total synthetic steps from
Ryan C. Harbit (14521878) +5 more
core +1 more source