Results 31 to 40 of about 2,729,303 (155)

Synthesis and Biological Evaluation of tert-Butyl Ester and Ethyl Ester Prodrugs of L-γ-Methyleneglutamic Acid Amides for Cancer [PDF]

, 2022
In cancer cells, glutaminolysis is the primary source of biosynthetic precursors. Recent efforts to develop amino acid analogues to inhibit glutamine metabolism in cancer have been extensive.
Md Imdadul , Khan, Seong Jong , Kim, Fakhri , Mahdi, Md Imran , Hossain, Patrice , Penfornis, Suresh, Sulochana, Jason, Paris, Hoang, Le, Chalet , Tan, Nicholas, Akins, Pier Paolo , Claudio, Tristan, Tran, Amna, Adam   +12 more
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Conformational Analysis of the D Ring of Lysergic Acid Amides and its Bioactive Conformation [PDF]

, 1985
1H, 13Cnuclear magnetic resonance data on simple lysergic acid amides and ergopeptines indieate eonsiderable flexibility of the D ring. The actual conformation depends upon the existence (or absence) of intramolecular hydrogen bonding between N6 and the ...
Kocjan, Darko, Kidrič, Jurkica, Hadži, Dušan   +2 more
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Construction of an efficient Claviceps paspali cell factory for lysergic acid production [PDF]

, 2023
Lysergic acid (LA) is the key precursor of ergot alkaloids, and its derivatives have been used extensively for the treatment of neurological disorders. However, the poor fermentation efficiency limited its industrial application.
Shaoxin Chen, Xuenian Huang, Wei Zhang, Xuan Zhang, Yu Zhou, Shen Tang, Xuefeng Lu, Yong Yang, Mingzhe Hu, Siyu Du, Zhou, Yu, Zhang, Xuan, Zhang, Wei, Chen, Shaoxin, Lu, Xuefeng, Tang, Shen, Huang, Xuenian, Hu, Mingzhe, Du, Siyu, Yang, Yong   +19 more
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SYNTHESIS OF 6-SUBSTITUTED NICOTINIC ACID DERIVATIVES AS LYSERGIC ACID ANALOGS.

, 1963
SYNTHESIS OF 6-SUBSTITUTED NICOTINIC ACID DERIVATIVES AS LYSERGIC ACID ...
JACOB. LEHRFELD (7956074)
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BMC Microbiology / Rhodococcus erythropolis MTHt3 biotransforms ergopeptines to lysergic acid [PDF]

, 2015
Background: Ergopeptines are a predominant class of ergot alkaloids produced by tall fescue grass endophyte Neotyphodium coenophialum or cereal pathogen Claviceps purpurea.
Kunz-Vekiru, Elisavet, Schatzmayr, Gerd, Schwartz-Zimmermann, Heidi Elisabeth, Gerd Schatzmayr, Michaela Thamhesl, Wolfgang Kneifel, Wulf-Dieter Moll, Moll, Wulf-Dieter, Apfelthaler, Elisabeth, Thamhesl, Michaela, Elisabeth Apfelthaler, Krska, Rudolf, Heidi Elisabeth Schwartz-Zimmermann, Kneifel, Wolfgang, Elisavet Kunz-Vekiru, Rudolf Krska   +15 more
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Essential Oils of Argyreia capitiformis (Poir.) Ooststr. and Argyreia nasirii D.F. Austin: Chemical Analysis and Biological Activities

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Essential oils of Argyreia capitiformis and Argyreia nasirii display clearly distinct chemical and biological profiles. A. capitiformis is dominated by sesquiterpene hydrocarbons, particularly (E)‐caryophyllene, and shows cytotoxicity against HepG2, SK‐LU‐1, and MCF‐7 cells. In contrast, A.
Tran Thi Ngoc Hanh, Nguyen Thi Thu Hien, Pham Van Huyen, Nguyen Huu Huong Duyen, Phan Nha Hoa, Tran Kim Diep, Nguyen Thi Dieu Thuan, Nguyen Huu Toan Phan   +7 more
wiley   +1 more source

5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence

British Journal of Pharmacology, Volume 183, Issue 16, Page 4715-4734, August 2026.
Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli, Deborah Rudin, Dino Luethi, Matthias E. Liechti, Sabrine Bilel, Matteo Marti, Henrik Green, Manuela Carla Monti, Caitlyn Norman   +8 more
wiley   +1 more source

Asymmetric Synthesis of Lysergic Acid via an Intramolecular (3+2) Dipolar Cycloaddition/Ring-Expansion Sequence

, 2021
An effective, potentially scalable asymmetric synthesis of lysergic acid, a core component of the ergot alkaloid family, is reported. The synthesis features the strategic combination of an intramolecular azomethine ylide cycloaddition and Cossy–Charette ...
Philip Garner (1831117), Philip Garner, Upendra Rathnayake, Upendra Rathnayake (6611201)   +3 more
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Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

pH Sensitive Anticancer Prodrug: Amide of Kemp's Acid [PDF]

, 2009
Solid tumours are characterised by lower extracellular pH (as low as 5.8 pH) compared to normal healthy cellular pH (actively regulated at pH 7.3). This difference may be exploited with an acid-sensitive anti-tumour prodrug which releases a cytotoxin ...
Brooks, Robert Turongo
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