Results 31 to 40 of about 12,110 (254)

An open-label pilot trial assessing tolerability and feasibility of LSD microdosing in patients with major depressive disorder (LSDDEP1)

open access: yesPilot and Feasibility Studies, 2023
Background Globally, an estimated 260 million people suffer from depression [1], and there is a clear need for the development of new, alternative antidepressant therapies.
Carina Joy Donegan   +17 more
doaj   +1 more source

Self unbound: ego dissolution in psychedelic experience [PDF]

open access: yes, 2017
Users of psychedelic drugs often report that their sense of being a self or ‘I’ distinct from the rest of the world has diminished or altogether dissolved.
Gerrans, Philip, Letheby, Chris
core   +2 more sources

Classical and non-classical psychedelic drugs induce common network changes in human cortex

open access: yesNeuroImage, 2023
The neurobiology of the psychedelic experience is not fully understood. Identifying common brain network changes induced by both classical (i.e., acting at the 5-HT2 receptor) and non-classical psychedelics would provide mechanistic insight into state ...
Rui Dai   +10 more
doaj   +1 more source

The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [PDF]

open access: yes, 2018
Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of
Erowid, Earth   +6 more
core   +2 more sources

Persisting Reductions in Cannabis, Opioid, and Stimulant Misuse After Naturalistic Psychedelic Use: An Online Survey

open access: yesFrontiers in Psychiatry, 2020
BackgroundObservational data and preliminary studies suggest serotonin 2A agonist psychedelics may hold potential in treating a variety of substance use disorders (SUDs), including opioid use disorder (OUD).AimsThe study aim was to describe and analyze ...
Albert Garcia-Romeu   +7 more
doaj   +1 more source

Shannon entropy of brain functional complex networks under the influence of the psychedelic Ayahuasca [PDF]

open access: yes, 2016
The entropic brain hypothesis holds that the key facts concerning psychedelics are partially explained in terms of increased entropy of the brain's functional connectivity.
de Araujo, Draulio B.   +4 more
core   +6 more sources

Histoire du LSD. De l’ergot de seigle à l’utilisation thérapeutique [PDF]

open access: yes, 2015
National audienceLe LSD, de l’allemand Lysergsäurediethylamid, est une substance hallucinogène utilisée à but récréatif. Également connue sous le nom d’« acide », cette molécule à propriétés psychotropes est classée en France comme un stupéfiant illicite
Gicquel, Thomas   +2 more
core   +3 more sources

Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD

open access: yeseLife, 2021
Psychoactive drugs can transiently perturb brain physiology while preserving brain structure. The role of physiological state in shaping neural function can therefore be investigated through neuroimaging of pharmacologically induced effects.
Joshua B Burt   +7 more
doaj   +1 more source

Over 30 million psychedelic users in the United States [v1; ref status: indexed, http://f1000r.es/w8]

open access: yesF1000Research, 2013
We estimated lifetime prevalence of psychedelic use (lysergic acid diethylamide (LSD), psilocybin (magic mushrooms), mescaline, and peyote) by age category using data from a 2010 US population survey of 57,873 individuals aged 12 years and older.
Teri S Krebs, Pål-Ørjan Johansen
doaj   +1 more source

Psychedelics as a Treatment for Alzheimer’s Disease Dementia

open access: yesFrontiers in Synaptic Neuroscience, 2020
Currently, there are no disease-modifying treatments for Alzheimer’s disease (AD) or any other dementia subtype. The renaissance in psychedelic research in recent years, in particular studies involving psilocybin and lysergic acid diethylamide (LSD ...
Simon Andrew Vann Jones   +1 more
doaj   +1 more source

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