Results 41 to 50 of about 12,110 (254)

MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of LSD in healthy volunteers

Trials, 2021
Background Regular ingestion of sub-hallucinogenic doses of psychedelics, referred to as “microdosing”, has gained increasing popularity and attention in the press and in online forums, with reported benefits across multiple cognitive and emotional ...
Robin J. Murphy, Rachael L. Sumner, William Evans, David Menkes, Ingo Lambrecht, Rhys Ponton, Frederick Sundram, Nicholas Hoeh, Sanya Ram, Lisa Reynolds, Suresh Muthukumaraswamy   +10 more
doaj   +1 more source

Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans [PDF]

, 2016
Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the psychedelic 5-HT2A and sigma-1 agonist N,N-dimethyltryptamine (DMT) plus ß-carboline alkaloids with ...
Alonso, Joan Francesc, Antonijoan Arbós, Rosa Ma (Rosa María), Barker, Steven, Feilding, Amanda, Friedlander, Pablo, Maqueda, Ana Elda, Mañanas, Miquel Àngel, Rabella, Mireia, Riba, Jordi, Rodríguez-Pujadas, Aina, Romero, Sergio, Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia, Valle, Marta   +12 more
core   +3 more sources

LSD degrades hippocampal spatial representations and suppresses hippocampal-visual cortical interactions

Cell Reports, 2021
Summary: Lysergic acid diethylamide (LSD) produces hallucinations, which are perceptions uncoupled from the external environment. How LSD alters neuronal activities in vivo that underlie abnormal perceptions is unknown.
Carli Domenico, Daniel Haggerty, Xiang Mou, Daoyun Ji   +3 more
doaj   +1 more source

LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality [PDF]

, 2016
Lysergic acid diethylamide (LSD) is used recreationally and has been evaluated as an adjunct to psychotherapy to treat anxiety in patients with life-threatening illness.
CG Frye, CJ Harmer, CM Hysek, CM Hysek, CM Hysek, CS Grob, DE Nichols, Felix Müller, FX Vollenweider, G Bedi, I Dziobek, KA MacLean, KH Preller, KP Kuypers, M Kometer, Matthias E Liechti, MC Mithoefer, MC Mithoefer, MC Wardle, MC Wardle, MG Kirkpatrick, MG Kirkpatrick, MP Bogenschutz, MW Johnson, P Gasser, P Gasser, P Oehen, P. Strajhar, Patrick C Dolder, Patrick C. Dolder, PC Dolder, R Hurlemann, RL Carhart-Harris, RL Carhart-Harris, RO Murphy, RR Griffiths, RR Griffiths, Stefan Borgwardt, T Passie, W Janke, Y Schmid, Y Schmid, Yasmin Schmid   +42 more
core   +1 more source

Intoxication of dogs and cats with common stimulating, hallucinogenic and dissociative recreational drugs

Veterinary and Animal Science, 2023
Pets can have accidental, intentional, or malicious exposure to illicit drugs. It is a growing concern over the last decade because there is an increase in usage of illicit drugs in humans and diagnosis is difficult.
Ena Oster, Nikola Čudina, Hrvoje Pavasović, Andreja Prevendar Crnić, Frane Božić, Charbel Fadel, Mario Giorgi   +6 more
doaj   +1 more source

Novel Psychoactive Substances: : the pharmacology of stimulants and hallucinogens [PDF]

, 2016
This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Clinical Pharmacology, on March 2016, available online at doi: : http://www.tandfonline.com/doi/full/10.1586/17512433.2016.1167597.There are increasing levels ...
Corkery JM, Daly M, Dargan PI, Fabrizio Schifano, Farrè M, G. Duccio Papanti, John M. Corkery, Laura Orsolini, Shulgin AT, Shulgin AT, Soussan C, Ujváry I   +11 more
core   +3 more sources

Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain

Journal of Fungi, 2022
Mushrooms have been used as traditional medicine for millennia, fungi are the main natural source of psychedelic compounds. There is now increasing interest in using fungal active compounds such as psychedelics for alleviating symptoms of mental health ...
Elaine Meade, Sarah Hehir, Neil Rowan, Mary Garvey   +3 more
doaj   +1 more source

Acute Effects of Lysergic Acid Diethylamide on Circulating Steroid Levels in Healthy Subjects [PDF]

, 2016
Lysergic acid diethylamide (LSD) is a serotonin 5-hydroxytryptamine-2A (5-HT2A ) receptor agonist that is used recreationally worldwide. Interest in LSD research in humans waned after the 1970s, although the use of LSD in psychiatric research and ...
Armario, Azizi, Bosch, Brown, Connell, Dolder, Dolder, Eisenegger, Evans, Frohman, Fuller, Gasser, Grossman, Hamidovic, Harris, Harris, Hasler, Hoagland, Hollister, Hysek, Hysek, Hysek, Hysek, Hysek, Johnson, Kar, Karssen, Kroboth, Lennartsson, Lu, Mello, Mendelson, Mendelson, Mitra, Murphy, Nadeem, Nichols, Oddie, Odermatt, Oswald, Passie, Rees, Rickli, Sackler, Schmid, Schmid, Schmid, Schmidt, Seibert, Seifritz, Simmler, Simmler, Sofuoglu, Sripada, Ward, Wolkowitz, Yonkers   +56 more
core   +1 more source

Modern Clinical Research on LSD [PDF]

, 2017
All modern clinical studies using the classic hallucinogen lysergic acid diethylamide (LSD) in healthy subjects or patients in the last 25 years are reviewed herein. There were five recent studies in healthy participants and one in patients.
A Garcia-Romeu, A Rickli, A Rickli, AB Wolbach Jr, AL Halberstadt, AL Halberstadt, Andrea E. Steuer, AV Lebedev, CM Hysek, CM Hysek, CS Grob, D Holland, D Marona-Lewicka, D Nutt, DB Terhune, DE Nichols, DE Nichols, DE Nichols, DV Sheehan, E Gouzoulis-Mayfrank, E Studerus, E Tagliazucchi, EA Schindler, F Hasler, F Mueller, FL Osorio, FX Vollenweider, FX Vollenweider, J Riba, J Seibert, J Speth, JC Bouso, JH Halpern, JJ Rucker, KA MacLean, KH Preller, KH Preller, KH Preller, KPC Kuypers, L Roseman, L Roseman, LD Simmler, LE Hollister, M Johnson, M Kaelen, M Kaelen, M Kometer, M Kometer, MA Geyer, Matthias E Liechti, ME Liechti, MJ Baggott, MP Bogenschutz, MW Johnson, P Gasser, P Gasser, P Strajhar, Patrick C. Dolder, PC Dolder, PC Dolder, PC Dolder, PS Hendricks, R Kraehenmann, Rainer Kraehenmann, RE Belleville, RG Dos Santos, RJ Strassman, RJ Strassman, RL Carhart-Harris, RL Carhart-Harris, RL Carhart-Harris, RL Carhart-Harris, RL Carhart-Harris, RL Carhart-Harris, RL Carhart-Harris, RR Griffiths, RR Griffiths, S Ross, SD Muthukumaraswamy, T Passie, TS Krebs, TS Krebs, WE Fantegrossi, WN Pahnke, WN Pahnke, Y Schmid   +85 more
core   +1 more source

Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects [PDF]

, 2017
Lysergic acid diethylamide (LSD) induces profound changes in various mental domains, including perception, self-awareness and emotions. We used functional magnetic resonance imaging (fMRI) to investigate the acute effects of LSD on the neural substrate ...
Borgwardt, S., Dolder, P. C., Harder, S., Lang, U. E., Lenz, C., Liechti, M. E., Mueller, F., Schmid, Y.   +7 more
core   +1 more source