Results 31 to 40 of about 37,615 (246)

Engineered Lysins With Customized Lytic Activities Against Enterococci and Staphylococci

Frontiers in Microbiology, 2020
The emergence of multidrug-resistant bacteria has made minor bacterial infections incurable with many existing antibiotics. Lysins are phage-encoded peptidoglycan hydrolases that have demonstrated therapeutic potential as a novel class of antimicrobials.
Hana Sakina Binte Muhammad Jai, Linh Chi Dam, Lowella Servito Tay, Jodi Jia Wei Koh, Hooi Linn Loo, Kimberly A. Kline, Kimberly A. Kline, Boon Chong Goh   +7 more
doaj   +1 more source

Complete Genome Sequences of Mycobacterium smegmatis Phages NihilNomen and Carlyle, Isolated in Las Vegas, Nevada [PDF]

, 2019
We present the complete genomes of the Mycobacterium smegmatis phages Carlyle and NihilNomen, isolated from soil in Las Vegas, Nevada. The phages were isolated and annotated by undergraduate students enrolled in the Phage Discovery course offered by the ...
Bhatti, Khadija, Dapra, Ciera, Doss, Ryan, Gildore, Alexis, Huntsinger, Audrey, Knudtson, Jacinda, Le, Alan, McFarland, Merissa, Mehta, Astha, Mekhaeel, Natalie, Mercado, Guadalupe, Ohta, Tiannah, Regner, Kurt, Rodrich-Zuniga, Edith, Rodriguez, Stephanie, Salisbury, Alicia, Sandberg, Rylee, Strong, Christy, Tibayan, Frances, Tsourkas, Phillippos K., Willer, Justin, Yacek, Scott, Zafar, Neha   +22 more
core   +2 more sources

Lysine Succinylation and Lysine Malonylation in Histones

Molecular & Cellular Proteomics, 2012
Histone protein post-translational modifications (PTMs) are significant for gene expression and DNA repair. Here we report the identification and validation of a new type of PTM in histones, lysine succinylation. The identified lysine succinylated histone peptides were verified by MS/MS of synthetic peptides, HPLC co-elution, and isotopic labeling.
Zhongyu, Xie, Junbiao, Dai, Lunzhi, Dai, Minjia, Tan, Zhongyi, Cheng, Yeming, Wu, Jef D, Boeke, Yingming, Zhao   +7 more
openaire   +2 more sources

A second endolysin gene is fully embedded in-frame with the lysA gene of mycobacteriophage Ms6. [PDF]

PLoS ONE, 2011
Mycobacteriophages are dsDNA viruses that infect mycobacterial hosts. The mycobacteriophage Ms6 accomplishes lysis by producing two cell wall hydrolytic enzymes, Lysin A (LysA) that possesses a central peptidoglycan recognition protein (PGRP) super ...
Maria João Catalão, Catarina Milho, Filipa Gil, José Moniz-Pereira, Madalena Pimentel   +4 more
doaj   +1 more source

Phage therapy: An alternative to antibiotics in the age of multi-drug resistance. [PDF]

, 2017
The practice of phage therapy, which uses bacterial viruses (phages) to treat bacterial infections, has been around for almost a century. The universal decline in the effectiveness of antibiotics has generated renewed interest in revisiting this practice.
Koskella, Britt, Lin, Derek, Lin, Henry
core   +1 more source

Phage vB_PaeS-PAJD-1 Rescues Murine Mastitis Infected With Multidrug-Resistant Pseudomonas aeruginosa

Frontiers in Cellular and Infection Microbiology, 2021
Pseudomonas aeruginosa is a Gram-negative pathogen that causes a variety of infections in humans and animals. Due to the inappropriate use of antibiotics, multi-drug resistant (MDR) P. aeruginosa strains have emerged and are prevailing.
Zhaofei Wang, Yibing Xue, Ya Gao, Mengting Guo, Yuanping Liu, Xinwei Zou, Yuqiang Cheng, Jingjiao Ma, Hengan Wang, Jianhe Sun, Yaxian Yan   +10 more
doaj   +1 more source

Mapping and Genotypic Analysis of the NK-Lysin Gene in Chicken [PDF]

, 2014
Antimicrobial peptides (AMP) are important elements of the first line of defence against pathogens in animals. NK-lysin is a cationic AMP that plays a critical role in innate immunity.
Cheng, Hans, Huang, Yong-Zhen, Lamont, Susan, Lamont, Susan, Lee, Mi, Lee, Sung, Lillehoj, Hyun, Morisson, Mireille, Muir, William, Vignal, Alain, Womack, James, Yang, Ence   +11 more
core   +7 more sources

Variation in hemolytic activity of Brachyspira hyodysenteriae strains from pigs [PDF]

, 2016
Brachyspira hyodysenteriae is the primary cause of swine dysentery, which is responsible for major economic losses to the pig industry worldwide. The hemolytic activity of 10 B.
Boyen, Filip, De Pauw, Nele, Ducatelle, Richard, Haesebrouck, Freddy, Mahu, Maxime, Martel, An, Pasmans, Frank, Vande Maele, Lien, Verlinden, Marc   +8 more
core   +4 more sources

Treating Bacterial Infections with Bacteriophage-Based Enzybiotics: In Vitro, In Vivo and Clinical Application

Antibiotics, 2021
Over the past few decades, we have witnessed a surge around the world in the emergence of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and misuse of antibiotics as well as a relative lack of new drug classes in
Katarzyna M. Danis-Wlodarczyk, Daniel J. Wozniak, Stephen T. Abedon   +2 more
doaj   +1 more source

Quorum sensing-controlled gene expression in lactic acid bacteria [PDF]

, 1998
Quorum sensing in lactic acid bacteria (LAB) involves peptides that are directly sensed by membrane-located histidine kinases, after which the signal is transmitted to an intracellular response regulator. This regulator in turn activates transcription of
Brurberg, de Ruyter, de Ruyter, de Vos, Diep, Diep, Eijsink, Engelke, Hühne, Klaenhammer, Kleerebezem, Kleerebezem, Kuipers, Kuipers, Kuipers, Kuipers, Nes, Parkinson, Platteeuw, Quadri, Quadri, Salmond, Saucier, Siezen, Skaugen, van der Meer   +25 more
core   +2 more sources