Results 51 to 60 of about 14,811 (174)

Fertilization of Ascidians: Gamete Interaction, Self/Nonself Recognition and Sperm Penetration of Egg Coat

Frontiers in Cell and Developmental Biology, 2022
Fertilization is one of the most important events in living organisms to generate a new life with a mixed genetic background. To achieve successful fertilization, sperm and eggs must undergo complex processes in a sequential order.
Takako Saito, Hitoshi Sawada, Hitoshi Sawada   +2 more
doaj   +1 more source

Impact of YAQ001 on the Gut Microbiome, Permeability and Markers of Systemic Inflammation in Patients With Cirrhosis

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background & Aims YAQ001 is a novel, non‐absorbable, gut‐restricted, multiporous, carbon bead adsorbent. Pre‐clinical studies and a clinical trial suggested its therapeutic potential and safety in patients with cirrhosis. This substudy aimed to explore the effects of YAQ001 on the gut microbiome and their exploratory association with ...
Jinxia Liu, Fernando Garcia‐Guevara, Jane Macnaughtan, Yi Jin, Ainhoa Ferret‐Miñana, Frederick Clasen, Nicholas Yuen, Ramón Garcia Maset, Javier Ramón‐Azcón, Annarein J. C. Kerbert, Theo Portlock, Javier Martinez, Abeba Habtesion, Alexandra Phillips, Francesco De Chiara, Ganesh Ingavle, Tom Baldwin, Cesar Jimenez, Giacomo Zaccherini, Katherine Husi, Miguel Rodriguez‐Gandia, Paul Cordero‐Sanchez, Junpei Soeda, Jude A. Oben, Karen Church, Jia V. Li, Aarti Jalan, Adria Juanola, Elsa Sola, Simon Eaton, Carrie Morgan, Thomas Avery, Michal Kowalski, Daniel Green, Amir Gander, Lindsey Ann Edwards, I. Jane Cox, Helena Cortez‐Pinto, Reiner Wiest, Francois Durand, Paolo Caraceni, Roberto Elosua, Joan Vila, Marco Pavesi, Vicente Arroyo, Nathan Davies, Rajeshwar P. Mookerjee, Susan Sandeman, Gautam Mehta, Julian R. Marchesi, Agustin Albillos, Jennifer L. Rohn, Fausto Andreola, Saeed Shoaie, Rajiv Jalan   +54 more
wiley   +1 more source

PL3 Amidase, a Tailor-made Lysin Constructed by Domain Shuffling

Frontiers in Microbiology, 2016
The emergence and spread of antibiotic-resistant bacteria is pushing the need of alternative treatments. In this context, phage therapy is already a reality to successfully fight certain multiresistant bacteria.
Blas Blázquez, Alba Fresco-Taboada, Manuel Iglesias-Bexiga, Margarita Menéndez, Pedro García   +4 more
doaj   +1 more source

Mechanisms of Sperm–Egg Interactions: What Ascidian Fertilization Research Has Taught Us

Cells, 2022
Fertilization is an essential process in terrestrial organisms for creating a new organism with genetic diversity. Before gamete fusion, several steps are required to achieve successful fertilization.
Hitoshi Sawada, Takako Saito
doaj   +1 more source

Hydro‐ and Lipophilicity of Molecular‐Size‐Controlled Hydrogel Drug Carriers

Advanced Materials Technologies, Volume 11, Issue 20, 21 October 2026.
We investigate nano‐sized hydrogel drug carriers with tailored hydro‐ and lipophilicity. We design their encapsulation and structure‐forming capabilities and follow them in real time during fabrication using time‐resolved and in situ grazing incidence x‐ray scattering.
Elisabeth Erbes, Naireeta Biswas, Calvin J. Gavillet, Matthias Schwartzkopf, Krishnayan Basuroy, Qing Chen, Andrei Chumakov, Susann Frenzke, Marc Gensch, Korneliya Gordeyeva, Patrycja Kielb, Sonja Kirchner, Volker Körstgens, Peter Müller‐Buschbaum, Henrike M. Müller‐Werkmeister, Jan Rubeck, Sreevidya Thekku Veedu, Jose de Jesus Velazquez‐Garcia, Vivian Waclawek, Daniel Söderberg, Stephan V. Roth, Simone Techert   +21 more
wiley   +1 more source

Modeling of the Ebola Virus Delta Peptide Reveals a Potential Lytic Sequence Motif

Viruses, 2015
Filoviruses, such as Ebola and Marburg viruses, cause severe outbreaks of human infection, including the extensive epidemic of Ebola virus disease (EVD) in West Africa in 2014. In the course of examining mutations in the glycoprotein gene associated with
William R. Gallaher, Robert F. Garry
doaj   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, Volume 13, Issue 56, 9 October 2026.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source

Hyperacute Interleukin‐1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion

Annals of Neurology, Volume 100, Issue 4, Page 824-840, October 2026.
Acute ischemic stroke due to large vessel occlusion is associated with rapid intravascular immune activation. Analysis of arterial blood sampled distal to the thrombus during mechanical thrombectomy revealed increased extracellular adenosine triphosphate (ATP) and interleukin‐1β (IL‐1β) levels, evidence of inflammasome priming in monocytes, and ...
Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa, Tim Magnus, Mathias Gelderblom   +33 more
wiley   +1 more source

Enzymes and Mechanisms Employed by Tailed Bacteriophages to Breach the Bacterial Cell Barriers

Viruses, 2018
Monoderm bacteria possess a cell envelope made of a cytoplasmic membrane and a cell wall, whereas diderm bacteria have and extra lipid layer, the outer membrane, covering the cell wall.
Sofia Fernandes, Carlos São-José
doaj   +1 more source