Results 181 to 190 of about 898,492 (409)
Delineating elastic properties of kinesin linker and their sensitivity to point mutations [PDF]
arXiv, 2018 We analyze free energy estimators from simulation trials mimicking single-molecule pulling experiments on a neck linker of a kinesin motor. For that purpose, we have performed a version of steered molecular dynamics (SMD) calculations. The sample trajectories have been analyzed to derive distribution of work done on the system.
arxiv
Tunable Thermoshrinkable Hydrogels for 4D Fabrication of Cell‐Seeded Channels
Advanced Functional Materials, EarlyView.A thermoresponsive polymer with methacrylate groups for photo‐cross‐linking, based on polyethylene glycol, N‐isopropylacrylamide, and 2‐hydroxyethyl acrylate is synthetized to yield hydrogels that shrink upon temperature increase. The new polymer enables the fabrication of cell‐laden perfusable channels with diameters below 200 µm by combining ...
Greta Di Marco +12 more
wiley +1 more source
Prob-cGAN: A Probabilistic Conditional Generative Adversarial Network for LSD1 Inhibitor Activity Prediction [PDF]
arXivThe inhibition of Lysine-Specific Histone Demethylase 1 (LSD1) is a promising strategy for cancer treatment and targeting epigenetic mechanisms. This paper introduces a Probabilistic Conditional Generative Adversarial Network (Prob-cGAN), designed to predict the activity of LSD1 inhibitors.
arxiv
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Poultry Science, 2020 Crystalline amino acids (AAs) exhibit high nutritional values when supplemented AA-deficient diets. However, the AAs in crystalline form in the diet are absorbed quickly than protein-bound AAs, which may take an effect on AA utilization efficiency.
Mingfa Sun +5 more
doaj
Advanced Healthcare Materials, EarlyView.Negative‐ and positive‐staining TEM is essential for rapid nanometer‐resolution characterization of organic specimens ranging from nanoparticles to cells. Uranyl salts are widely used negative‐/positive‐stains but are radioactive and highly toxic to users and the environment.
Vera M. Kissling +4 more
wiley +1 more source
Journal of Applied Poultry Research, 2020 Summary: Previous research has shown that feeding high amino acid density (AAD) diets or increased AME improved broiler performance, though the relationship between AAD and AME on performance needs to be further explored. Therefore, the objective of this
R.A. Hirai +5 more
doaj
Advanced Healthcare Materials, EarlyView.Rod‐shaped particles outperform spherical particles of the same volume in preventing neutrophil infiltration to inflamed areas, both in vitro and in vivo. This therapeutic effectiveness is attributed to better cell targeting and decreased cell motility, resulting from the geometry‐driven phagocytosis and inhibited actin polymerization.
M. Valentina Guevara +7 more
wiley +1 more source
Deep-Ace: LSTM-based Prokaryotic Lysine Acetylation Site Predictor [PDF]
arXivAcetylation of lysine residues (K-Ace) is a post-translation modification occurring in both prokaryotes and eukaryotes. It plays a crucial role in disease pathology and cell biology hence it is important to identify these K-Ace sites. In the past, many machine learning-based models using hand-crafted features and encodings have been used to find and ...
arxiv
PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY
Journal of Histochemistry and Cytochemistry, 1974 I. W. Mclean, P. Nakane
semanticscholar +1 more source