Results 21 to 30 of about 996,868 (382)
Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388. [PDF]
, 2020 COR388, a small-molecule lysine-gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease.
Arastu-Kapur, Shirin +10 more
core +1 more source
Protein lysine crotonylation: past, present, perspective
Cell Death and Disease, 2021 Lysine crotonylation has been discovered in histone and non-histone proteins and found to be involved in diverse diseases and biological processes, such as neuropsychiatric disease, carcinogenesis, spermatogenesis, tissue injury, and inflammation.
Gaoyue Jiang +4 more
semanticscholar +1 more source
Poultry Science, 2020 Crystalline amino acids (AAs) exhibit high nutritional values when supplemented AA-deficient diets. However, the AAs in crystalline form in the diet are absorbed quickly than protein-bound AAs, which may take an effect on AA utilization efficiency.
Mingfa Sun +5 more
doaj +1 more source
A Novel Peptide-Based SILAC Method to Identify the Posttranslational Modifications Provides Evidence for Unconventional Ubiquitination in the ER-Associated Degradation Pathway. [PDF]
, 2013 The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for disposing misfolded proteins from the endoplasmic reticulum by inducing their ubiquitination and degradation.
Anania, Veronica +4 more
core +3 more sources
Journal of Applied Poultry Research, 2020 Summary: Previous research has shown that feeding high amino acid density (AAD) diets or increased AME improved broiler performance, though the relationship between AAD and AME on performance needs to be further explored. Therefore, the objective of this
R.A. Hirai +5 more
doaj +1 more source
Lysine Succinylation and Lysine Malonylation in Histones
Molecular & Cellular Proteomics, 2012 Histone protein post-translational modifications (PTMs) are significant for gene expression and DNA repair. Here we report the identification and validation of a new type of PTM in histones, lysine succinylation. The identified lysine succinylated histone peptides were verified by MS/MS of synthetic peptides, HPLC co-elution, and isotopic labeling.
Zhongyu, Xie +7 more
openaire +2 more sources
Jurnal Kelautan Tropis, 2020 Reducing feed cost in the vaname (Litopenaeus vannamei) cultivation can be achieved by increasing quality of commercial feed. To increase the feed quality is by adding lysine amino acid, because lysine is one of the amino acids that can boost fish ...
Diana Rachmawati +3 more
doaj +1 more source
Tunable multiphase dynamics of arginine and lysine liquid condensates
Nature Communications, 2020 Liquid phase separation into two or more coexisting phases has emerged as a new paradigm for understanding subcellular organization, prebiotic life, and the origins of disease.
Rachel S. Fisher, Shana Elbaum-Garfinkle
semanticscholar +1 more source
Upregulation of Transglutaminase andε(γ-Glutamyl)-Lysine in the Fisher-Lewis Rat Model of Chronic Allograft Nephropathy [PDF]
, 2014 Background. Tissue transglutaminase (TG2), a cross-linking enzyme, modulates deposition of extracellular matrix protein in renal fibrosis. This study aimed to examine TG2 and its cross-link product ε(γ-glutamyl)-lysine in the Fisher-Lewis rat renal ...
Butt, Imran +7 more
core +3 more sources
Efficiency of lysine utilization by growing meat quail
Poultry Science, 2021 The objective of present study was to estimate the efficiency of lysine utilization by meat quail of 21 to 35 d of age. A total of 500 meat quails were distributed in a completely randomized design in a 2 × 5 factorial arrangement, with 2 sexes (male and
J.C. Siqueira +7 more
doaj +1 more source