Results 81 to 90 of about 945,171 (383)

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand [PDF]

, 1992
We have constructed an artificial ligand for the hepatocyte-specific asialoglycoprotein receptor for the purpose of generating a synthetic delivery system for DNA.
Ashwell G., Atherton E., Atherton E., Baenziger J. U., Christian Plank, Connolly D. T., Corley Cain C., Curiel D. T., DeWet J., Ellman G. L., Ernst Wagner, Gotten M., Gotten M., Gotten M., Huckett B., Karl Mechtler, Kempen H. J. M., Knowles B. B., Kurt Zatloukal, Lee Y. C., Matt Cotten, Orrantia E., Patek P.Q., Rosenkranz A. A., Seifter S., Severne Y., Spiess M., Tam J. P., Wagner E., Wagner E., Wagner E., Wagner E., Wharton S. A., Wu C., Wu G. Y., Zatloukal K., Zenke M.   +36 more
core   +1 more source

Chemo- and Regioselective Lysine Modification on Native Proteins

Journal of the American Chemical Society, 2018
Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods, based on synthetic and biochemical technologies, can achieve site selectivity, but these ...
M. Matos, Bruno L. Oliveira, N. Martínez-Sáez, A. Guerreiro, P. Cal, Jean B. Bertoldo, M. Maneiro, Elizabeth Perkins, Julie A. Howard, M. Deery, J. Chalker, F. Corzana, Gonzalo Jiménez‐Osés, G. Bernardes   +13 more
semanticscholar   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

PATHOLOGICAL EFFECTS OF FEEDING COTTONSEED MEAL WITH AND WITHOUT LYSINE IN MALE JAPANESE QUAILS (COTURNIX JAPONICA) [PDF]

Pakistan Veterinary Journal, 2007
A total of 84 male Japanese quails (Coturnix japonica) of 40 days of age were randomly divided into seven groups (A to G) with 12 birds in each group. A corn and soybean meal based feed having 25% proteins was offered to group A (control) as a basal feed.
M. ILYAS, M. K. SALEEMI, F. MAHMOOD AND M. Z. KHAN
doaj  

High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1. [PDF]

, 2018
Polybromo-1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl-lysine residues.
Alicea-Velázquez, Nilda L., Cai, Weijia, Cho, Eun-Ah, Cosgrove, Michael S., Greer, Celeste B., Langbein, Lauren, Liao, Lili, Niu, Xiaohua, Yan, Qin, Yang, Haifeng, Zhang, Meiling   +10 more
core   +2 more sources

Cellular functions and molecular mechanisms of non-lysine ubiquitination

Open Biology, 2019
Protein ubiquitination is of great cellular importance through its central role in processes such as degradation, DNA repair, endocytosis and inflammation.
A. J. McClellan, Sophie Heiden Laugesen, L. Ellgaard   +2 more
semanticscholar   +1 more source

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

Molecular Oncology, EarlyView.
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová, Hana Svozilová, Marcela Krzyžánková, Radim Sonnek, Anastasiya Volakhava, Anastasia Smirnova, Tatiana Grigoreva, Zuzana Jašková, Hana Synáčková, Dennis Wahl, Michaela Bilčíková, Libor Červinek, Šárka Pospíšilová, Ilgar Mamedov, Karla Plevová   +14 more
wiley   +1 more source

Phosphorus Response and Amino Acid Composition of Different Green Gram (Vigna radiata L.) Genotypes from Myanmar

Journal of Agriculture and Rural Development in the Tropics and Subtropics, 2007
Mungbean or green gram (Vigna radiata L.) is an important component of rice-based cropping systems in Myanmar, where grain yields of around 800 kg ha^(-1) are much below its yield potential of 3000 kg ha^(-1).
M. Kywe, Andreas Buerkert, M. R. Finckh
doaj  

Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. [PDF]

, 2017
Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes. Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tail of SUMO proteins ...
Ahmad, Alla S, Bennett, Eric J, Clauser, Karl R, Gu, Hongbo, Komives, Elizabeth A, Leonard, Marilyn, Lumpkin, Ryan J, Meyer, Jesse G, Zhu, Yiying   +8 more
core   +2 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source