Results 101 to 110 of about 4,831 (203)

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Sirt5-mediated desuccinylation of OPTN protects retinal ganglion cells from autophagic flux blockade in diabetic retinopathy

Cell Death Discovery, 2022
Retinal neurodegeneration develops early in the course of diabetic retinopathy (DR), and our previous research showed that succinate accumulation results in retinal ganglion cells (RGCs) dysfunction in the retinas of rats with DR.
Ye Zhang, Tingting Li, Xuan Cai, Da Long, Xiangning Wang, Chang Liu, Qiang Wu   +6 more
doaj   +1 more source

Vegetable protein isolates [PDF]

, 2009
This chapter discusses the importance of vegetable proteins as functional ingredients in food formulations. It provides an overview of the main chemical components, world production, history and food applications of the main vegetable protein sources ...
Arellano, Juan B., González Pérez, Sergio   +1 more
core   +1 more source

SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease [PDF]

, 2020
Mitochondrial acyl-coenzyme A species are emerging as important sources of protein modification and damage. Succinyl-CoA ligase (SCL) deficiency causes a mitochondrial encephalomyopathy of unknown pathomechanism.
Alkhater, Reem A., Carroll, Christopher J., Christen, Stefan, Civiletto, Gabriele, Euro, Liliya, Gut, Philipp, He, Wenjuan, Isohanni, Pirjo, Jackson, Christopher B., Liu, Xiaojing, Locasale, Jason W., Matilainen, Sanna, Meyer, Jesse G., Minassian, Berge A., Moco, Sofia, Newman, John C., Nishida, Yuya, Ostergaard, Elsebet, Pallijeff, Pieti, Parisi, Alice, Rardin, Matthew J., Richard, Joy, Schilling, Birgit, Suomalainen, Anu, Thevenet, Jonathan, Verdin, Eric   +25 more
core   +2 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Global proteome analyses of phosphorylation and succinylation of barley root proteins in response to phosphate starvation and recovery [PDF]

, 2022
Phosphate (Pi) stress is an important environmental factor that limits plant growth and development. Of various posttranslational modifications (PTMs), protein phosphorylation and succinylation are the two most important PTMs that regulate multiple ...
Li, B., Li, C., Ma, X., Ma, Z., Meng, Y., Ren, P., Shang, X., Si, E., Wang, H., Wang, J., Yang, K., Yao, L.   +11 more
core  

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Conformational destabilization of Bacillus licheniformis α-amylase induced by lysine modification and calcium depletion [PDF]

, 2011
Bacillus licheniformis α-amylase (BLA) was chemically modified using 100-fold molar excess of succinic anhydride over protein or 0.66 M potassium cyanate to obtain 42 % succinylated and 81 % carbamylated BLAs.
Abdul Kadir, Habsah, Raja Abdul Rahman, Raja Noor Zaliha, Tan, Cheau Yuaan, Tayyab, Saad   +3 more
core  

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia [PDF]

, 2014
Nonalcoholic fatty liver disease (NAFLD) spectrum disorders affect approximately 1 billion individuals worldwide. However, the drivers of progressive steatohepatitis remain incompletely defined.
Baris Ercal, Befroy, Chen, D. André d’Avignon, David G. Cotter, Dennis J. Dietzen, Elizabeth M. Brunt, Gary J. Patti, Hegardt, Jamison M. Leid, Jitrapakdee, Kanehisa, Mark J. Graham, Peter A. Crawford, Robinson, Sengupta, Serviddio, Soeters, Tautenhahn, Thumelin, Thurston, Williamson, Williamson, Williamson, Williamson, Wolf, Xiaojing Huang   +26 more
core   +2 more sources

Linking Nutritional, Sensory, and Functional Quality in Plant‐Based Proteins Through Structural Modification and Computational Insights

Sustainable Food Proteins, Volume 4, Issue 1, March 2026.
The lacking essential amino acids, low digestibility, bioavailability, bitterness, and presence of anti‐nutritional factors that limit the consumption of plant proteins and their use in food formulations are discussed comprehensively. The findings of recent studies on novel technologies and computer‐based applications used to cope with these challenges
Humeyra Cavdar Dincturk, Rukiye Gundogan, Asli Can Karaca, Esra Capanoglu   +3 more
wiley   +1 more source