Results 81 to 90 of about 94,143 (143)

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Lysine Succinylation and Acetylation in Pseudomonas aeruginosa

, 2018
Pseudomonas aeruginosa is a multi-drug-resistant human opportunistic pathogen largely involved in nosocomial infections. Unfortunately, effective antibacterial agents are lacking.
Charlotte Gaviard (5317526), Pascal Cosette (375609), Emmanuelle Dé (4407484), Broutin, Isabelle, Pascal Cosette, Isabelle Broutin, Julie Hardouin, Gaviard, Charlotte, Hardouin, Julie, Isabelle Broutin (1663189), Dé, Emmanuelle, Jouenne, Thierry, Thierry Jouenne, Emmanuelle Dé, Thierry Jouenne (200627), Cosette, Pascal, Charlotte Gaviard, Julie Hardouin (635990)   +17 more
core   +1 more source

Proteomics and succinylation modification characterization in clear cell renal cell carcinoma

Discover Oncology
Clear cell renal cell carcinoma (ccRCC) represents the most lethal form of kidney cancer, with a significant number of patients experiencing tumor progression.
Dong Yue, Miao Zheng
doaj   +1 more source

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source

Quantification of Site-specific Protein Lysine Acetylation and Succinylation Stoichiometry Using Data-independent Acquisition Mass Spectrometry [PDF]

, 2018
Post-translational modification (PTM) of protein lysine residues by NƐ-acylation induces structural changes that can dynamically regulate protein functions, for example, by changing enzymatic activity or by mediating interactions.
Lei Wei, Jesse G. Meyer, Wei, Lei, Birgit Schilling, Schilling, Birgit, Meyer, Jesse   +5 more
core   +1 more source

KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma

Signal Transduction and Targeted Therapy
Posttranslational modification succinylation plays a pivotal role in tumorigenesis across malignancies, yet its mechanistic contributions to hepatocellular carcinoma (HCC) pathogenesis and therapeutic resistance remain poorly characterized. In this study,
Jun Wu, Jingsheng Yuan, Zijian Liu, Yongjie Zhou, Bo Zhang, Yahong Xu, Qiwen Zeng, Zhenru Wu, Lingxiang Kong, Jiaguo Wang, Bohan Zhang, Jian Yang, Tao Lv, Yujun Shi, Jiayin Yang   +14 more
doaj   +1 more source

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

Cell Reports, 2018
Summary: Lysine succinylation was recently identified as a post-translational modification in cells. However, the molecular mechanism underlying lysine succinylation remains unclear. Here, we show that carnitine palmitoyltransferase 1A (CPT1A) has lysine
Kiran Kurmi, Sadae Hitosugi, Elizabeth K. Wiese, Felix Boakye-Agyeman, Wilson I. Gonsalves, Zhenkun Lou, Larry M. Karnitz, Matthew P. Goetz, Taro Hitosugi   +8 more
doaj   +1 more source

Comprehensive analysis of the lysine acetylome in Aeromonas hydrophila reveals cross-talk between lysine acetylation and succinylation in LuxS

, 2019
Lysine acetylation and succinylation are both prevalent protein post-translational modifications (PTMs) in bacteria species, whereas the effect of the cross-talk between both PTMs on bacterial biological function remains largely unknown.
Yuying Fu (6371582), Lishan Zhang (3765937), Yuqian Wang (619491), Ranran Mao (7309040), Zujie Yao (1643632), Lina Sun (158687), Yuexu Lin (7309043), Xiangmin Lin (1643635), Zhuang Guo (547032)   +8 more
core   +1 more source

Protein succinylation: regulating metabolism and beyond

Frontiers in Nutrition
Modifications of protein post-translation are critical modulatory processes, which alters target protein biological activity，function and/or location, even involved in pathogenesis of some diseases. So far, there are at least 16 types of post-translation
Xiaoli Hou, Yiqiu Chen, Xiao Li, Xianliang Gu, Weixia Dong, Jie Shi, Shaoping Ji, Shaoping Ji   +7 more
doaj   +1 more source