Results 71 to 80 of about 94,143 (143)

Site-Specific Installation of Succinyl Lysine Analog into Histones Reveals the Effect of H2BK34 Succinylation on Nucleosome Dynamics

, 2018
Posttranslational modifications of histones play key roles in the dynamic regulation of chromatin structure. Lysine succinylation is a new type of histone modification, but its biological significance in chromatin structure and dynamics remains unknown ...
Bao, Xiucong, Yihang Jing, Xiucong Bao, Liu, Z, Zheng Liu, Li, Xiang David, Xiang David Li, Tian, Gaofei, Tian, G, Li, XD, Ishibashi, Toyotaka, Ishibashi, T, Toyotaka Ishibashi, Jing, Y, Bao, X, Liu, Zheng, Gaofei Tian, Jing, Yihang   +17 more
core   +1 more source

Table2_Deep_KsuccSite: A novel deep learning method for the identification of lysine succinylation sites.XLSX

, 2022
Identification of lysine (symbol Lys or K) succinylation (Ksucc) sites centralizes the basis for disclosing the mechanism and function of lysine succinylation modifications.
Liang Wang (23021), Ting Yang (189879), Lin-Lin Xu (1556689), Ya-Ping Lu (4452577), Xin-Yu Gu (11921680), Yong Liu (6908), Xin Liu (43569)   +6 more
core   +1 more source

Mucuna pruriens as a Sustainable Functional Food: Applications From Seed to Product

Modern Agriculture, Volume 4, Issue 2, December 2026.
This review highlights Mucuna pruriens as a nutrient‐rich legume with significant nutritional, therapeutic, and agricultural value. Its protein‐rich seeds contain essential minerals and L‐DOPA, but high antinutritional compounds require effective processing before consumption.
Crossby Osei Tutu, Reuben Acheampong, Papa Toah Akonor, Bernard Kwabena Asiedu, Rexford Obeng, Anthonia Helga Andoh‐Odoom, Dora Duah‐Bisiw, Jacob Ulzen, Michael Wiafe‐Kwagyan, Nii Korley Kortei, Justice Owusu‐Bempah   +10 more
wiley   +1 more source

Table3_Deep_KsuccSite: A novel deep learning method for the identification of lysine succinylation sites.XLSX

, 2022
Identification of lysine (symbol Lys or K) succinylation (Ksucc) sites centralizes the basis for disclosing the mechanism and function of lysine succinylation modifications.
Liang Wang (23021), Ting Yang (189879), Lin-Lin Xu (1556689), Ya-Ping Lu (4452577), Xin-Yu Gu (11921680), Yong Liu (6908), Xin Liu (43569)   +6 more
core   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorizin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, Volume 4, Issue 3, September 2026.
We constructed a Pt‐TiO2 mesoporous nanocarrier to co‐deliver phlorizin for HCC synergistic sonodynamic‐chemoimmunotherapy. This nanoplatform targets DDX5 to remodel tumor metabolism, triggers mitochondrial damage, suppresses tumor proliferation, and elicits potent anti‐tumor immune responses by activating T cells and boosting immune cytokines in mice.
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

Lysine succinylation of Mycobacterium tuberculosis isocitrate lyase (ICL) fine-tunes the microbial resistance to antibiotics

, 2016
Lysine succinylation (Ksucc) is a newly identified protein posttranslational modification (PTM), which may play an important role in cellular physiology. However, the role of lysine succinylation in antibiotic resistance remains elusive. Isocitrate lyase
Longxiang Xie (1696417), Zhaozhen Yang (2574574), Jiahai Zhou (407473), Mingliang Zhou (172233), Jianping Xie (550373)   +4 more
core   +1 more source

CPT1A through succinylation regulates the CTCF/LINC01503‒91aa feedback loop to promote gemcitabine resistance in pancreatic ductal adenocarcinoma

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
LINC01503 encoded a 91‐amino acid protein named 1503‒91aa, which enhanced carnitine palmitoyl transferase 1A (CPT1A) activity and regulated fatty acid oxidation (FAO) by competitively binding to malonyl‐CoA. Meanwhile, we found a positive feedback loop whereby CPT1A acts as a succinyltransferase to stabilise CTCF (a transcription factor driving ...
De‐Liang Fang, Si‐Yuan Lu, Zhi‐De Liu, Qiong‐Cong Xu, Yang‐Yinhui Yu, Ying‐Qin Zhu, Ming‐Jian Ma, Jing‐Yuan Ye, Xiao‐Yu Yin   +8 more
wiley   +1 more source

SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob miceResearch in context

EBioMedicine, 2018
Background: Sirtuin 5 (SIRT5) is a NAD+-dependent lysine deacylase. The SIRT5 deficiency mouse model shows that it is dispensable for metabolic homeostasis under normal conditions.
Yipeng Du, Hao Hu, Saisi Qu, Jifeng Wang, Chaoju Hua, Jialing Zhang, Peng Wei, Xiaolong He, Junfeng Hao, Pingsheng Liu, Fuquan Yang, Tingting Li, Taotao Wei   +12 more
doaj   +1 more source