Results 101 to 110 of about 94,143 (143)

Sirt5 KO induces increased lysine succinylation and decreased ATP synthase activity in mouse heart mitochondria.

, 2019
(A-C) Lysine succinylation, malonylation and glutarylation are dramatically increased in mitochondria of Sirt5 KO mouse heart. Male Sirt5 KO mice (n = 3) and WT control mice (n = 3) (16–28 weeks old) were fasted overnight.
Dan Ye (180080), Yuzheng Zhao (731859), Xiaoxia Wang (14667), Lei Zhang (38117), Hui Wang (30400), Yukun Xia (794008), Yue Xiong (794009), Kun-Liang Guan (794010), Yi Yang (116183), Qi Kang (2414137), Peng Liu (120506), Xiaoting Tao (6291101), Jian Wu (41301), Renqiang Sun (1649389), Jinye Zhang (1467106), Yunzeng Zou (188550), Mengli Zhang (6331172)   +16 more
core   +1 more source

The enzyme activity of mitochondrial trifunctional protein is not altered by lysine acetylation or lysine succinylation. [PDF]

PLoS One, 2021
Zhang Y, Goetzman E.
europepmc   +1 more source

Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation

Nature Communications
Gemcitabine combined with cisplatin is the first-line chemotherapy for advanced cholangiocarcinoma, but drug resistance remains a challenge, leading to unsatisfactory therapeutic effect.
Ning Zhang, Linmao Sun, Shuo Zhou, Changyong Ji, Tianming Cui, Qi Chu, Jiareng Ye, Shuhang Liang, Kun Ma, Yufeng Liu, Xianying Li, Xinyu Guo, Weizhi Zhang, Xuetian Gu, Cheng Cheng, Qingrui Zha, Shengwei Tao, Yunguang Zhang, Junhui Chu, Chenghui Wu, Yuchen Zhang, Jiabei Wang, Yao Liu, Lianxin Liu   +23 more
doaj   +1 more source

Rhamnolipid Enhances the Nitrogen Fixation Activity of Azotobacter chroococcum by Influencing Lysine Succinylation. [PDF]

Front Microbiol, 2021
Li J, Pan H, Yang H, Wang C, Liu H, Zhou H, Li P, Li C, Lu X, Tian Y.   +9 more
europepmc   +1 more source

Systematic Analysis of the Lysine Succinylome in Candida albicans

, 2016
Candida albicans is the most common human fungal pathogen for both immunocompetent and immunocompromised individuals. Lysine succinylation is a frequently occurring post-translational modification that is found in many organisms; however, the role of ...
Xiaofang Li (212165), Hailin Zheng (1399576), Guanyu Qian (2855468), Dongmei Li (176178), Weida Liu (848554), Xiaowei Zhou (1332225), Guixia Lv (3129138), Yongnian Shen (419020), Yun He (40953), Jiyun Liu (553498)   +9 more
core   +1 more source

First analyses of lysine succinylation proteome and overlap between succinylation and acetylation in Solenopsis invicta Buren (Hymenoptera: Formicidae). [PDF]

BMC Genomics, 2022
Ye J, Li J.
europepmc   +1 more source

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

, 2013
Protein function is regulated by diverse posttranslational modifications. The mitochondrial sirtuin SIRT5 removes malonyl and succinyl moieties from target lysines. The spectrum of protein substrates subject to these modifications is unknown.
Zwaans, Bernadette M.M., Xie, Zhongyu, Skinner, Mary E., Zhao, Yingming, Chen, Yue, Dai, Lunzhai, Park, Jeongsoon, Tishkoff, Daniel X., Tan, Minjia, Zhang, Yi, Lombard, David B., Peng, Chao   +11 more
core   +1 more source

Succinylation: novel molecular mechanisms and prospects for targeted therapy in liver diseases

Frontiers in Molecular Biosciences
Succinylation is a novel post-translational modification involving the attachment of a negatively charged succinyl group to lysine residues, which fundamentally alters the structure and function of substrate proteins.
Jie Zhou, Xiaoling Tian, Yifang Zhou, Nianhua Tan, Bin Chen   +4 more
doaj   +1 more source

LSTMCNNsucc: A Bidirectional LSTM and CNN-Based Deep Learning Method for Predicting Lysine Succinylation Sites. [PDF]

Biomed Res Int, 2021
Huang G, Shen Q, Zhang G, Wang P, Yu ZG.
europepmc   +1 more source

Succinylation: A novel regulatory axis in cholelithiasis-insights from lysine acetyltransferase 2A/adenosine monophosphate-activated protein kinase signaling

Cholelithiasis represents a common clinical condition within the digestive tract and continues to pose a substantial global health challenge, largely due to its high rate of recurrence and a scarcity of effective non-surgical interventions.
Xiao, Fan, Wei, He-Rui
core   +1 more source