Results 111 to 120 of about 4,831 (203)

SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob miceResearch in context

EBioMedicine, 2018
Background: Sirtuin 5 (SIRT5) is a NAD+-dependent lysine deacylase. The SIRT5 deficiency mouse model shows that it is dispensable for metabolic homeostasis under normal conditions.
Yipeng Du, Hao Hu, Saisi Qu, Jifeng Wang, Chaoju Hua, Jialing Zhang, Peng Wei, Xiaolong He, Junfeng Hao, Pingsheng Liu, Fuquan Yang, Tingting Li, Taotao Wei   +12 more
doaj   +1 more source

Dynamic responses of barley root Succinyl-Proteome to Short-Term phosphate starvation and recovery [PDF]

, 2021
Barley (Hordeum vulgare L.)—a major cereal crop—has low Pi demand, which is a distinct advantage for studying the tolerance mechanisms of phosphorus deficiency.
Li, B., Li, C., Ma, X., Ma, Z., Meng, Y., Ren, P., Shang, X., Si, E., Wang, H., Wang, J., Yang, K., Yao, L.   +11 more
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, Volume 600, Issue 4, Page 418-438, February 2026.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Proteomics and succinylation modification characterization in clear cell renal cell carcinoma

Discover Oncology
Clear cell renal cell carcinoma (ccRCC) represents the most lethal form of kidney cancer, with a significant number of patients experiencing tumor progression.
Dong Yue, Miao Zheng
doaj   +1 more source

Lipophilisation des protéines biocatalysées par des lipases : cas des isolats de protéines de soja [PDF]

, 1997
La lipophilisation par biocatalyse a été effectuée sur des isolats de protéines de soja, riches en lysine. Les réactions ont été conduites à 60 degrés C avec et sans solvant en mettant en oeuvre une lipase fixée (lipozyme) ou libre (lipase S de Rhizopus ...
Graille, Jean, Huc, Alain, Perrier, Eric, Pina, Michel, Roussel, Coralie   +4 more
core  

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense [PDF]

, 2016
Excess in mitochondrial reactive oxygen species (ROS) is considered as a major cause of cellular oxidative stress. NADPH, the main intracellular reductant, has a key role in keeping glutathione in its reduced form GSH, which scavenges ROS and thus ...
Chen, Xiufei, Guan, Kun-Liang, Sun, Renqiang, Wang, Fang, Wang, Shiwen, Wang, Yi, Xiong, Yue, Xu, Qi, Yang, Pengyuan, Ye, Dan, Yu, Hongxiu, Zhang, Mengli, Zhou, Lisha   +12 more
core   +2 more sources

CRISPR‐Cas9 screen reveals that inhibition of enhancer of zeste homolog 2 sensitizes malignant T cells to dimethyl‐fumarate‐induced cell death

The FEBS Journal, Volume 293, Issue 3, Page 749-765, February 2026.
A genome‐wide CRISPR‐Cas9 screen identified H3K27 methylation as a key regulator of T‐cell lymphoma sensitivity to dimethyl fumarate (DMF). Specifically, inhibition of enhancer of zeste homolog 2 (EZH2) enhanced DMF‐induced cell death in malignant T cells. These results provide functional evidence for the role of EZH2 in modulating drug sensitivity and
Jan P. Teubner, Deniz Tümen, Arne Kandulski, Philipp Heumann, Patricia Mester, Elisabeth Aschenbrenner, Kirstin Pollinger, Manuela Gunckel, Barbara Volz, Tobias Hein, Paul L. Beltzig, Luisa Tengler, Florian Voll, Marina Kreutz, Claudia Kunst, Jan P. Nicolay, Martina Müller, Karsten Gülow   +17 more
wiley   +1 more source

HMGB1 Stimulates Activity of Polymerase β on Nucleosome Substrates [PDF]

, 2017
The process of base excision repair (BER) recognizes and repairs small lesions or inappropriate bases on DNA through either a short-patch or long-patch pathway.
Balakrishnan, Lata, Balliano, Angela, Hao, Fanfan, Hayes, Jeffrey J., Njeri, Catherine   +4 more
core   +2 more sources

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

A systematic identification of species-specific protein succinylation sites using joint element features information

International Journal of Nanomedicine, 2017
Md Mehedi Hasan,1 Mst Shamima Khatun,2 Md Nurul Haque Mollah,2 Cao Yong,3 Dianjing Guo1 1School of Life Sciences and the State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, New Territory, Hong Kong, People’s ...
Hasan MM, Khatun MS, Mollah MNH, Yong C, Guo D   +4 more
doaj