Results 71 to 80 of about 42,626 (246)

PhageLeads: Rapid Assessment of Phage Therapeutic Suitability Using an Ensemble Machine Learning Approach

open access: yesViruses, 2022
The characterization of therapeutic phage genomes plays a crucial role in the success rate of phage therapies. There are three checkpoints that need to be examined for the selection of phage candidates, namely, the presence of temperate markers ...
Kumarasan Yukgehnaish   +8 more
doaj   +1 more source

From bacterial predators to partners: phages in agriculture. [PDF]

open access: yesNew Phytol
Summary Bacteriophages, viruses that infect bacteria, are critical players for shaping the taxonomic and functional composition of plant‐associated microbiomes. Yet, their roles in plant health remain overlooked, along with their implications for sustainable agriculture.
Salehimoghaddam Z, Hynes AP, Doyle RT.
europepmc   +2 more sources

Transient-mediated fate determination in a transcriptional circuit of HIV [PDF]

open access: yes, 2007
Steady-state behavior and bistability have been proposed as mechanisms for decision-making in gene circuits. However, transient gene expression has also been proposed to control cell fate with the decision arbitrated by the lifetime of the expression ...
Leor Weinberger   +2 more
core   +1 more source

Automated Imaging of Cultured Bacteria in Picoliter Droplets by Coherent Anti‐Stokes Raman Scattering and Two‐Photon Excited Fluorescence Microscopy

open access: yesJournal of Raman Spectroscopy, EarlyView.
We present an automated system that combines an image‐based fuzzy logic controller for precise positioning of microfluidic picoliter droplets with nonlinear microscopy, using CARS and TPEF modalities for detailed analysis of droplet composition. Time series and z‐stack images of E. coli, B. subtilis, and M. arborescens were recorded.
Fabian Ott   +6 more
wiley   +1 more source

Transcriptome analysis of bacteriophage communities in periodontal health and disease. [PDF]

open access: yes, 2015
BackgroundThe role of viruses as members of the human microbiome has gained broader attention with the discovery that human body surfaces are inhabited by sizeable viral communities.
Abeles, Shira R   +5 more
core   +2 more sources

Glyco‐Nanogels for Modulating Pseudomonas aeruginosa Biofilm

open access: yesMacromolecular Rapid Communications, EarlyView.
Nanogels presenting α‐galactose and β‐fucose can significantly alter Pseudomonas aeruginosa biofilm dynamics through their interaction with lectins. Application timing is crucial: pre‐treatment reduces biofilm, while treatment after biofilm initiation increases biomass.
Sophia Rosencrantz   +4 more
wiley   +1 more source

Frenemy: adaptive temperate phage_SAP_1432 supports Staphylococcus aureus survival in changing temperatures

open access: yesMicrobiology Spectrum
It is important to understand how the presence of pathogens could benefit the survival of their hosts during climate change. In this study, we investigated the influence of the heat-resistant temperate phage phage_SAP_1432 on its bacterial host ...
Ting-ting Liu   +6 more
doaj   +1 more source

Studies on Lysogeny in Staphylococci [PDF]

open access: yesJournal of General Microbiology, 1957
SUMMARY: A staphylococcus typing phage (NCTC 8426) was found to form lysogenic systems with three strains of staphylococci. In the case of two of these strains, staphylococci lysogenically infected with the typing phage were now lysed by the temperate phages they had previously carried. This loss of immunity was due to the replacement of the originally
openaire   +2 more sources

Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates. [PDF]

open access: yes, 2012
UnlabelledInvestigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial ...
Bowman, Charles   +13 more
core   +2 more sources

Clinicopathological characteristics of patients with inoperable non‐small cell lung cancer harboring circulating NRF2 pathway mutations

open access: yesThe Journal of Pathology, EarlyView.
Abstract Lung cancer is the leading cause of global cancer‐related morbidity and mortality, with tobacco smoking as its strongest risk factor. Nuclear factor erythroid 2‐related factor 2 (NRF2) is a redox‐regulated transcription factor frequently dysregulated in non‐small cell lung cancer (NSCLC), leading to aggressive disease and resistance to therapy.
Jouni Härkönen   +14 more
wiley   +1 more source

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